Can you get high on Depade?

No, Depade does not get you high. Read on for more information about how Depade is used for treating drug dependency and as a treatment for addiction here.

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No, Depade cannot get you high.

Instead, the main ingredient found in Depade – naltrexone – is prescribed for alcohol and opioid addiction treatment. In fact, it blocks the euphoric effects these substances create in the brain. Depade is often combined with different types of psychotherapy to have successfully recover from opioid and alcohol use and get clean.

Here, we explore the effects of Depade and how it works in the brain and body. At the end, we invite your comments and questions about the effects of Depade treatment for opioid addiction and alcoholism. We try to respond to all questions with a personal and prompt reply.

Depade use and chemistry: What’s in Depade?

Depade is used to ease cravings in people who are alcohol dependent. It contains naltrexone as the main ingredient, which blocks cravings and helps improve a person’s ability to abstain from drinking. By blocking the pleasure from alcohol, Depade may also reduce the amount of heavy drinking in those who do drink.

When used by former opiate/opioid addicts, Depade blocks the pleasurable and euphoric effects of narcotic drugs like heroin, morphine, codeine, hydrocodone, or oxycodone… even though it has a little to no effect on drug cravings.

How does Depade work in the brain?

1. Depade used to treat drinking problems

Alcohol produces feeling of pleasure by stimulating the release of neurotransmitters in the brain, chemicals  such as dopamine, serotonin, and opioid peptides. Dealing is prescribed to help block these feelings and to manage cravings related to drinking.


Depade blocks the brain’s chemical responses that make alcohol rewarding. In this way, Depade helps people to avoid drinking and remain sober.

2. Depade for opiates or opioid drugs

When used as a medication in the management of opioid drug addiction, Depade may not stop drug cravings. Instead, naltrexone blocks opioids and opiates from affecting the brain, while taking away the feeling of being high. Talk with your doctor if Depade does not help you coping with substance abuse, so s/he can provide you with different or alternative solution to reduce cravings.

Depade effects on the central nervous system effects

Depade is an opioid antagonist that binds at the µ-opioid, k-opioid and the d-opioid receptors. By binding to these receptors in the central nervous system (CNS), Depade reduces or completely blocks the subjective effects of alcohol and opioids. In fact, this prescription drug is known to effectively reduce alcohol use and alcohol cravings in people. However, scientists still do not completely understand the mechanism of action, or how it works in the CNS, for alcoholism.

Mixing Depade with other substances

Mixing Depade with other substances may change the way this medicine works and increase the chances of having unpleasant and adverse reactions. When taking this medicine, it’s better to consult your doctor about all other pills or substances you are using, so s/he can determine all possible unwanted side effects. These are some of the substances that Depade (naltrexone) can possibly interact with:

  • Anticoagulants
  • Antidiarrheal Medicines
  • Cough medicines
  • Narcotics or opioid analgesics

Depade for alcohol and opioid dependence treatment

Depade is not a magical pill that will solve addiction. It is mainly used in combination of cognitive behavioral therapies or support groups. In fact, Depade treatment for drug dependency should be made in consultation with a doctor who will make detail analysis of persons condition.

However, Depade is not compatible for use in everyone’s case. Undesirable effects may occur and you need to be aware about them when starting Depade therapy. If you consider starting Depade therapy, it is better to have in mind all positive and negative effects of its usage. Here is a list of pros and cons of using Depade for addiction treatment:

+ PRO’s

  • blocks the pleasurable effects of substance use
  • effective reduction of alcohol or drug consumption
  • prevent you from experiencing alcohol cravings and possible relapse
  • secures a stable and less stressful treatment

– CON’s

  • may lead to unintentional and fatal opioid or opiate overdose (it blocks their effects)
  • should not be consumed by opiate dependent people (painkillers or illicit drugs)
  • not recommended for pregnant or breastfeeding women
  • possible liver damage if more than recommended dose is injected (for Vivitrol)
  • unexpected side-effects

Questions about Depade?

Still have question about Depade and how it is used for treating alcoholism or drug dependency? Please send us your questions or experiences in the comments section below and we will try to provide answers to your questions promptly.

Reference Sources: NCBI: Oral Naltrexone
NIDA: Naltrexone – An Antagonist Therapy for Heroin Addiction
NIH: Naltrexone
Pubchem: Naltrexone
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.
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