Can you get high on oxycodone?

Yes. You can get high on oxycodone. More on the adverse effects of oxycodone and risks of oxycodone addiction here.

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Yes. You can get high on oxycodone.

Oxycodone is a narcotic medication found in a number of brand name drugs (oxycodone compared to OxyContin is almost the same thing). Oxycodone is habit forming. Doctors expect users to develop tolerance to oxycodone and experience withdrawal symptoms when they stop taking oxycodone. But is there a connection between getting high on oxycodone and addiction? Who is at risk? We review getting high on oxycodone and the risks of oxycodone addiction here. Your questions about oxycodone use are welcomed at the end.

Oxycodone chemistry and use

Oxycodone is an opiate pain killer used to treat moderate to severe pain. Oxycodone compared to hydrocodone provides similar pain relief, but oxycodone withdrawal is more severe.  So how does oxycodone work? Oxycodone alters the brain and nervous system’s response to pain. Because it acts on the brain, oxycodone can have a variety of side effects that impact various systems of the body, including the central nervous system.

Drugs that contain oxycodone

OxyContin, Dazidox, Endocodone, Oxceta, Oxyfast, Percolone, and Roxicodone are all brand names for oxycodone. Oxycodone is found mixed with acetaminophen in Endocet, Percocet, Rocicet, and Tylox. It’s combined with asprin in Endodan, Percodan, and Roxiprin. In Combuno, it’s mixed with ibuprofen.

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Oxycodone and euphoria

Oxycodone creates a euphoric high because it affects the pleasure centers of the brain. Ordinarily, this high is strongest the first time someone uses oxycodone, and the effects diminish over time. People taking oxycodone for pain management may not experience feelings of euphoria at all. But the deep sense of well-being that oxycodone can trigger, combined with oxycodone’s addictive nature, causes people to abuse oxycodone, even if you start taking it as prescribed.

Oxycodone and central nervous system effects

Oxycodone is a central nervous system depressant. When used in normal doses, any of the follow side effects can occur:

  • dizziness and lightheadedness
  • headache
  • mood changes
  • weakness

Oxycodone can also cause some serious adverse effects related to the central nervous system, which include:

  • confusion
  • difficulty breathing
  • fainting
  • fast or slow heartbeat
  • hallucinations
  • slowed breathing
  • seizures

Mixing oxycodone with other substances

Oxycodone is often mixed with alcohol or other drugs to enhance drug effects. Mixing oxycodone is a dangerous practice. Central nervous system depressants like alcohol and anti-anxiety medications increase the risk of serious adverse effects or overdose. Mixing oxycodone and the wrong substances can easily land you in the ER.

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Oxycodone high dangers

Oxycodone overdose is a very serious problem if you are using oxycodone to get high. Why? Because oxycodone is habit-forming and users build a tolerance to the medication over time. This can result in increased doses that can cause overdose on oxycodone, acetaminophen or ibuprofen. Overdose is an especially serious risk with acetaminophen, which can cause liver damage at even relatively low doses when not taken correctly.

Another risk of using oxycodone to get high is oxycodone addiction and withdrawal from the medication. If you stop taking oxycodone suddenly, the withdrawal can cause a variety of symptoms ranging from sleeplessness, to aches and pains, to mood swings. Although oxycodone withdrawal syndrome is not life threatening, symptoms can be very uncomfortable and difficult to manage. This is why doctors recommend users detox from oxycodone only under medical supervision.

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Help for oxycodone abuse

If you think that you have a problem with oxycodone, you probably do. But if you’re addicted to oxycodone, you have nothing to be ashamed of – narcotic addiction is a common problem and there are resources to help. Firstly, your doctor can give you medical advice on weaning yourself from oxycodone if you’re physically dependent on it. Sometimes, medical treatments are available to help treat opiate addiction. Your doctor can also direct you to support groups and refer you for therapy to help you overcome oxycodone addiction.

There are also steps you can take to help yourself get off oxycodone for good. Surround yourself with a supportive community of family and friends. Avoid people, places, and situations that will tempt you to abuse oxycodone. Making a few simple changes in your life can sometimes be the difference between relapse and staying sober.

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Getting high oxycodone questions

Do you still have questions about getting high on oxycodone? Please ask them here. We will do our best to provide you with a personal and prompt response ASAP.

Reference Sources: PubMed Health: Oxycodone
MedLine Plus: Hydrocodone/oxycodone overdose
DEA Office of Diversion Control: Oxycodone 
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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    1. Hi Karim. OxyContin contains active and inactive ingredients. The active ingredient is oxycodone hydrochloride, while inactive ingredients include: butylated hydroxytoluene (BHT), hypromellose, polyethylene glycol 400, polyethylene oxide, magnesium stearate, titanium dioxide, etc. You may read more here:

      Also, consult with your doctor as well as a pharmacist before taking the medication.

  1. Ive bn taking this med for over 22 yrs n ive never experience a high n if i did i didn’t know of it r felt it ,however i know when im hurting it work relieving 95 percent of my pain!

  2. I have been taking Hydrocodone for 18 years and recently they switched me to oxycodone A332 white tablet , Like anything in life there is a Use and Abuse factor , It’s not a good thing to take more than what the Doctor has prescribed , In fact if you can get by on less , you’ll have more when you really need it , I do not feel addicted but the withdraws tell me that I am , Knowing this I try as hard as I can to take only the amount I need to function as it is NO Fun being out of your Pain Medication for day’s on end , If you think your dependent on Opiates well you most likely are , If you want to detox there are numbers right here on this page , Good Luck .

  3. Hi,

    6 weeks of pill called targin, 40 mg oxy and 20 mg of something else to keep the bowels regular plus 20 mg of oxy as per required and my prescribing doc had said “just stop”. I am furious, I knew I was going through withdrawals as I had quit smoking just over a year ago, 4 days later and I’m doing better. I fell like I have been walking around on someone else’s legs if that makes sense, barely slept but coming good. I will never take an opioid type drug again if I can’t avoid it.

    Shannon from Australia

    Thanks for your article to help me understand what is going on with my body and brain at the moment.

  4. Hi I was prescribes Endone – oxycodone today & just took 7 x 5mg small white tablets,that was over 1 hour ago on a empty stomach & so far I feel very little effect.Certainly not the euphoria everyone raves about.while taking for the 1st time.I must sdmit I have a natural high tolerence to any medication,for example when I take Valium which is very seldom it takes at least 4 x 5mg tablets to feel any effect.Are there any other ways to admister these drugs to get a stronger high?I don’t like taking so many tablets to get the desired effect..

  5. My sister has 5 teeth taken out and was prescribed these pill I seen her how it leaves her and was wondering how long it takes to take effect and how long it lastes?

  6. My sister is additived to oxycodone due to r/a also takes Xanax and lexapro she is young but looks old she’s pulling her hair out walks and asleep and moans all the time what can I do

    1. Hi Marijean. Have you considered getting professional help for your sister? I believe she can recover well if she is taken off the medications in a medical and safe setting, and she can start working on her recovery after she is off the drugs. Feel free to call the helpline number displayed on our site to get in touch with our trusted treatment providers and see what options may be best for her.

  7. am on 30mg oxycodone for 2 years for lung cancer pain and possibly liver. it is no longer working. dr wouun’t tell me what a stronger doosee would help me. I know I am going too die so why should he care. can you tell me what a safe dose would be. I am 76 yrs old. any help would be appreciated. I wish pot was leaglle hhere in fl. god bless

  8. Hi,

    I’ve been really depressed lately and cant seem to get over something that happend a while back. My friends thinks I am over it and have moved past it but its getting hard keeping a straight face so I started smoking weed to just somewhat escape reality but as of late i just feel empty. I’ve been introduced to oxy and was wondering if 10mg and weed is a dangerous mix?

    1. Hello Sam. It is never recommended to mix two different drugs. I’d suggest you talk with someone about your problems, maybe if you open to your friends, they will help you get trough.

  9. Can I die from snoring 40mg this morning around 6:30 am and it’s now 6:00 pm ??very stupid of me doing this due to me getting off the oxicodone and didn’t feel anything with oxicodone. Flushed them down the toilet

  10. Hello Andrew. There is hope! You are not alone. Inpatient and outpatient treatment centers are all over the country. I’d suggest that you call 1-800-662-HELP to connect with someone who can refer you a local rehab. You can do it!

  11. I do at leist 4 30s blues a day a need help mixed with meth and drinking and weed im fucked feel like shit like dying and im 23 years old

  12. Hi Mike. It’s a honest suggestion to stop trying to achieve the initial effects. Your tolerance is increasing as you increase doses, and the feeling will never be what it once was. It’s a one way street that leads to dependence and many underlying health risks.

  13. I used to take one 30mg roxy daily to get by my oain daily. One pill, used to make me feel so good. Now i take up to 5 at a time and idont feel anything. My question is, is it pointless to take anymore? How many is to many to take at once.. I dont want to die

  14. I have had severe crohn’s disease for the past 5 years. I am in the process of weaning off. My hospital pain management doctor had me on 40mg for 5 years. March 7th through the 15th I was in the hospital. The pain management doctor decided to take me off of percocet. On the first day, he dropped me down to 3 pills/ 10mg a day. I was restless that night and had bad cravings for it, so he added more medicines to counteract with percocet. It did help to a degree by easing the side effects. On the second day, he had me on 5/325mg 4 pills a day for week 1, 3 pills a day for week 2, 2 pills a day or week 3 and 1 pill a day for week 4 and then stop. I am currently on the 3 pills a day for week 2. I am also taking cymbalta, neuontin, seroquel,. I am on a couple of other meds for crohn’s only. I have not experienced any problems since that night in the hospital when I was feeling restless, anxious and some cravings. I was constantly reminded by the nurses that your mind is telling you that you need this medicine. I do not drink, smoke or do any other drugs at all, and I MEAN IT. I have to go see the surgeons at John Hopkins in early May. The only thing the was scary to me was the fact that since I am being taken down by one pill a week, I don’t have anything to compare it to. YOU CAN DO THIS. DO NOT LET YOUR MIND CONTROL YOU. The pain management doctor and the nurses that I had in the hospital I had were right. It took me a while to fully grasp the what was happening and it’s easy to tell a patient who is being weaned off this terrible drug that everything will be o.k, but the patient is in a state of panic. That was the hardest thing for me to not think about, and I had help. You can do it! To those that read my post, Thank You and God Bless.

  15. their is an epidemic in our school system with heroin. I was told by local police its cause kids cant pay for the oxy. and that heroin is cheaper . what should i look for if my kids were to try Oxy? what does it do to them and there eyes ? attitudes and demeanor

  16. Hi Rudy. Hmmm. You’re asking whether or not after irregular use of oxycodone you can be physically dependent. I’m not really sure, as physical dependence is usually based on daily use but is subject to personal variables. If you can go 3-5 days without oxycodone and no side effects, you are unlikely to be physically dependent. However, to be sure, you may want to consult a detox clinic and ask them the same question and possibly withdraw in a residential or (at least) an outpatient basis to get the best medical care possible.

  17. If you were taking three tablets per week for recreation and stress relief of Oxycodone APAP5/325 would that create an additction and could you withdraw cold turkey effectively at home?

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