Can you get high on Prozac?

Yes. You can get high on fluoxetine, the active ingredient in Prozac, although euphoria is infrequent. Prozac high and more Prozac drug info here.

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Yes. Euphoric effect has been reported by Prozac users.

But getting high on Prozac is fairly rare. In fact, only about .1 – 1% of users report feelings of extreme well-being while using Prozac. Instead, most Prozac users report stable mood improvements rather than feeling high. Can you benefit from the way that Prozac affects the central nervous system and increased availability of serotonin in the body? Learn more about Prozac mechanisms and how Prozac works here.

Prozac chemistry and use

Prozac is prescribed for mental health disorders such as depression, obsessive compulsive disorders, panic disorder and bulimia. Prozac is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Other antidepressant SSRI drugs that you may have heard of include Trazodone and Zoloft. Getting high on trazodone is not possible. But getting high on Prozac and catching a Zoloft high are both possible.


Serotonin is a chemical naturally found in the body, which is responsible for mood, appetite and sleep. Increased or more readily available amounts of serotonin can help elevate mood, and contribute to feelings of well-being that are important when treating mental health disorders. So how do SSRIs like Prozac work?  You may be surprised to learn that scientists don’t really know HOW Prozac works yet. But they do have a theory. The active ingredient in Prozac, fluoxetine, blocks the uptake of serotonin in human platelets. So experts assume that Prozac inhibits neural uptake of serotonin in the central nervous system, making serotonin more available and elevating mood.

Prozac and central nervous system effects

Prozac may impair judgment, thinking, or motor skills. And you can experience nervous system effects such as changes in sleeping habits, tremors or shaking and even anxiety. But some nervous system effects are more serious and should be reported to your prescribing doctor. What are these symptoms and why do they occur?

Prozac, like other antidepressants, affects the central nervous system in ways that we cannot predict. And although Prozac can be very helpful for some people, Prozac has also been associated with an increased risk for suicidal thinking and behavior. It’s especially important that you monitor effects on the nervous system when you first start taking Prozac or during dosage changes. Symptoms of nervous system agitation should be reported immediately because they require close monitoring and possible change of medication. Report the following symptoms (especially if they are severe, abrupt in onset, or were not present during diagnosis) or any unusual behavior immediately to your doctor:

  • aggressiveness
  • agitation
  • anxiety
  • elation
  • hostility
  • hyperactivity
  • ideas of suicide
  • impulsivity
  • insomnia irritability
  • manic episodes
  • panic attacks
  • restlessness
  • worsening of depression

Mixing Prozac with other substances

Do not drink alcohol while taking Prozac, as the combined effect of the two drugs can impair decision making, clear thinking and reaction times. You should also tell your doctor about any other prescription medications, over-the-counter drugs, vitamins, or herbal supplements that you are taking. This is because some drugs interact very badly with Prozac. For example, you should not take any other medicines that contain fluoxetine hydrochloride while taking Prozac. Also, inform your doctor if you plan to discontinue any medications while taking Prozac.

Can you get addicted to Prozac?

We don’t know yet.

Prozac has been shown to be an effective medication for short term use (less than 13 weeks) but has not been clinically tested for long term prescription. Therefore, Prozac has not been studied enough to determine potential for drug abuse, tolerance, or physical dependence. However, only 1 in 100 to 1 in 1000 people on Prozac reported getting high on the antidepressant, indicating low risk for drug seeking behavior. But it’s still not possible to predict if Prozac will be misused, diverted, and/or abused in the future.

If you or someone you care about are struggling with addiction to Prozac…help is available. So, get ready to get better! You can learn more about Prozac addiction, available treatment options and rehab programs in our comprehensive guide for Antidepressant Addiction Treatment Programs and Help.

Questions about Prozac use or abuse

Do you have any other questions about taking Prozac? Or maybe you fear that you are abusing Prozac. Whatever your concern, please leave your questions below. We will be happy to answer them personally, or even write you a new article to address your Prozac question.

Reference sources: FDA approved Prozac drug label
Wikipedia topic on serotonin
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. Hi I am a highshooler who is doing a drug project on this medication. I was wondering how people use it? Also its been hard to find how it smells, tastes and how it enters the body. Thanks I justwant to know.

  2. I started Prozac 4 years ago, and it’s been a real life-saver: I didn’t feel depressed before, but angry and “pressured” and that went away and I was able to see life more realistically. I give it a lot of credit for helping me evaluate my life and make some good changes. About a year ago, I started feeling really happy, excessively??? I attributed this to figuring out some life-long issues and changing some behaviors, and attribute the frequent eubullience I feel to that. I still feel like myself and sharp, not “stoned”, but maybe it’s time to cut back??? Also, in the last year I noticed an uptick in my desire to drink alcohol, and now wonder if that is self medicating, in an attempt to knock down the euphoria a bit, as alcohol is a depressant.

  3. My dr perscribed prozac 10 mg which ive been taking now for 4 months daily. The effect has been well afyer the first few weeks. She said I had to take it at least 6 months before tapering down. I saw on this site that its not adviced to take over 13 weeks. What is your take on this?

    I feel well. I have forgotten to take it maybe 2-3times (not in a row) and immediately felt less ok that day. Surely not as bad as it used to be. And also there were stressful events on all those occasions, so me feeling less ok might also be from that instead of missing a dose.

  4. I do believe 10 mg is as low as you can get. I take 10 mg of prozac daily and it helps me so much. I feel like this is a great drug for the people that it helps. However I also feel like it would help more people if given a smaller dosage. When I was younger I was also on prozac however I was on a higher dose. And I had problems with not being able to get mad. But as I saw reading comments, if your not able to get mad and are just in that euphoric high on 10 mg this is probably not the medication for you…

  5. I just started Prozac 20mg 2 days ago, my arms, legs and body is jerking in different places at different times, cannot sleep either. Is this normal?

  6. I’ve been taking 20mg fluoxetine for 10days now, started taking them in the morning but more or less straight away I started having side affects, so tired no motivation wanting to sleep all day and no appetite which worries me because my doctor told me that this will help with my appetite. I couldn’t get out of bed for over a week!! So I found some post on the internet saying that some people take them at night so I though I’d give it a try as it was driving me nuts, three nights later and I haven’t slept a wink im at my wits end now and still having side effects but my energy is coming back but the trembling and teath clenching mostly in the night and mornings is driving me insane!! I’m not seeing my doc until Wednesday but I’m on the verge of changing the tablets back to mornings, it’s just as well my doc gave me a two week paper for work because there’s no way I would of been able to function in work and would be a danger to my co workers. Also I ve been taking the tablets at 7.00pm but if I change back to taking them in the mornings will I be wanting to sleep all day??? Help this isn’t fair on my family they’ve been amazingly supportive as I’ve been through a very traumatic year and I know I need something for my depression but other medications I’ve taken have made me ill and don’t want to try another drug

  7. I wss stsrted on prozac, anf klonopin for my axiety, 0.5 mg. Bid. But its making me not sleep and anxiety worst. What should i do. Thanks

  8. Thank you. I found this to be very informative. I take Prozac acc it works exceptionally well for me. There have been manic episodes on higher doses although, simply adjusting dosage corrects this.

  9. Would there be more of a rush if you snorted Prozac? Or is that just a waste of time? And would the insomnia irritably cancel out Benzos or take away from them? If you know what I mean. Like a 4mg xan

    1. Hi Jesse. Please consider that it is illegal to consume medications other than prescribed, and you put yourself at risk.

  10. I’ve been on 40 mg 1x a day for three weeks now and I love it. I feel a disconnected feeling, but I welcome it. When I would worry about things my mind would lock itself into a pattern of repetition and it would drive my anxiety up the wall. Now, not only is my mind no longer locking into a pattern of though, my mind won’t even enter a certain pattern that would before drive me crazy. I am thankful for this med.

  11. I had a question regarding the chemicals found in the powder of fluoxetine capsules. A friends of mine was charged with possession of cocaine after police allegedly opened the capsules and submitted the powder to a drug field test. The test showed positive for cocaine. I KNOW for a definite fact that my friend has no connections to illicit substances or any desire to be in possession let alone use the substances so I presume it must have been a false positive. Is this a possibility?

  12. I’ve been taking the generic for Prozac for 5 yrs. starting with 20mg and when it was changed to 40mg I was like a zombie and just sat stupefied all the time. My husband was concerned and suggested I try getting off the drug. I have slowly backed it down to 10mg and stopped taking the med. at the same time I take my HBP, & fluid meds. I was having EXTREAM HEADACHES before cutting it down. Now, however, I’m getting angry easily, and having more of my bipolar symptoms. I believe I feel better, but could be getting a little manic. I’m now taking 10mg every 3rd day and have been on this dosage for 3-4 weeks now. Can I get back on the 20mg now without side effects? Also, if I’m a little bipolar, do I need to take this med. for the rest of my life? ( I’m not having any headaches at all now) Does this generic medication cause headaches?

    1. Hello, Jason. Prozac is not a controlled substance under the Controlled Substance Act, so most times it’s not tested. But, some pain doctors do test for antidepressants.

  13. Hi
    My mothers just been takin into hodpital for overdosing on prozac while drinking.She took 24 prozac can you tell me the effects of this please

    1. Hello, Jenna. I’m really sorry about your mother. I hope everything will be fine. Experts clam that some patients experienced sequelae after overdose, including abnormal accommodation, elevated blood pressure, nervousness, confusion, movement disorder, unresponsiveness, pulmonary dysfunction, tremor, and hypomania. Also, there could be seizures, nausea, somnolence, and vomiting.

    1. Hi David. Maybe your dose is higher than your current tolerance level, so the medication is causing the euphoric effects. I suggest you speak with your doctor to see whether you should just keep taking it as you are now until you get used to it, or your doctor will adjust the dosage.

  14. I took fluoxetine-10 mg for 11 days for my depression and today was my last day of taking it. I am concerned about having withdrawal symptoms and possibly being addicted to it.

  15. I have recently been prescribed 20mg prozac. My question is,does it have an interaction with medical marijuana? I only use marijuana at night before i go to bed to help with my osteoarthritis in both knees,it helps with stiffness and pain in the mornings. Are there any interactions i need to be aware of? Thanks 🙂

    1. Hello Kance. Marijuana is a depressant and its chronic use can cause or aggravate the feelings of depression. Some of the most common side effects of Prozac include nervousness, drowsiness, anxiety, and insomnia; while marijuana is also known to cause mood swings, sleepiness or sluggishness, and, sometimes, decreased motivation. Moreover, marijuana has been found to decrease the effect of Prozac. Using the two drugs together could make it hard to determine whether Prozac is actually useful or not.

  16. Can Prozac give hallucinations ? My son is 17 and has Autism, he suffers from anxiety and panic attacks . The dr prescribed him Prozac 20mg . I notice him at times like delusional or having hallucinations. The problem is that he can’t comunicate much. I don’t know what to do ,something tells me I should stop this medication.

    1. Hello Feliz. Yes, one of the side effects of Prozac is the occurrence of hallucinations. Call your son’s doctor for medical advice about side effects and guidance on what should be done next. You may report side effects to FDA at 1-800-FDA-1088. I wish you and your son all the best!

  17. Hi , I was seeing a therapist and he write me prozac and after 1 month I’ve moved to a new location so I didn’t see my therapist again but I’ve taking prozac 20mlg daily and tow days ago I felt that it’s enough with prozac and anti depressant drugs so I stopped it . today I’m very nervous and I have a very bad headache . I’ve taken it for about 10 weeks , and i feel a little worried about that

  18. I have started taking prozac for like 3 days every morning it makes me feel calm an happy an i usually get depressed alot but prozac helps will i get addictive to it or any long term affects an im 14

  19. I have severe anxiety and depression. And when me and my doctor were talking about it, he only prescribed me Fluxetine. Will my anxiety get worse or will it get better?

  20. Just wondering about abuse , its just my son and myself in the home and I’ve been missing some of my Prozac about 1/3 of the monthly prescription I receive I have also found rolled up money in his laundry at first I thought it must be cocaine until I notice medications was disappearing. Any answers would be greatly appreciated. Thank you, Suzann

    1. Hi Suzann. Finding out you have medications missing and then finding a snorting tool is enough evidence to get suspicious. You can have an open conversation with your son. No judgements, hard feelings or anger should be involved, otherwise he will simply shut you out. If he refuses to speak, you can order a drug test to make sure that he’s abusing it. Then, you can search for the help of a counselor, psychiatrist or a treatment program. I hope this is resolved the easy way. Good luck!

  21. I started 40 mg fluoxitine since last Friday. Today I woke up happier and high-like!!! I do feel dreamy. I must say I feel good. Ran 7 miles! I feel better than I have ever felt in a long time. I’m assuming it will slow down a bit in the coming weeks. Right?!!!

  22. Can prozac just not work after taking it for 6 months. My son is super hyper sensitive. No drug has ever worked very long. He has had Neroleptic syndrome from Haldol. He had been taking 10mg of prozac 2xdaily

    1. Hi jj Icenogle. Yes, it is possible. Our organisms get adapted to substances very quickly. That’s called tolerance. It means that your son’s body is accustomed to the presence of Prozac and thus cannot feel the same effect he used to. I’d advise you to talk this issue over with your son’s doctor.

  23. I was prescribed a very high dosage which I kind of need but I felt as if nothing was real and that I was living in a dream. I would rather have a mind at peace and not as much happiness than basically thinking I’m living in a dream.

    1. Hi James. Have you shared your thoughts and preferences with your doctor? There must be something that can be done.

  24. Hi Ellen. Do you feel a need to get high on any drug or medication or particularly Prozac? No, it’s not a common side-effect but it may be a sign of an addictive personality. Maybe you can ask your doctor or a counselor for advise.

  25. Hi, I’m on 40mg Prozac daily. Since starting them I just seem to have a desire to get high, self medicate to get high. Is this a normal side effect? Will it go?
    Thank you

  26. Dear John. it is normal for your SO to yawn. i take prozac and i find that it makes me yawn an insane amount. maybe you should talk to her doctor because by the way you are explaining her behavioral pattern it seems to me that Prozac is not helping her at all. This is crucial because you both have a young child and she is putting him or her in alot of danger so it seems. Maybe she needs another anti depressant to take also with prozac or just no prozac at all completely. i hope my reply was helpful to you.

  27. John, could it be that your other half is just not happy with you? It looks like you’re looking to blame a drug for something that could be your fault. Most people on Prozac have moments of clarity, they sometimes lack basic emotion such as guilt. If she feels she had to stay with you just for the baby’s sake then there’s a chance to Prozac has made her unable to feel the guilt of staying with u and she’s decided the best thing to do is move on. Have u even asked her why she does what she does? If she’s in a bad way then u need to not make it all about u. You can never assume u know what she’s thinking

  28. I’ve been taking Prozac 10mg for the past five days. So far, I am feeling more high and full of energy than I ever have been. I’m a little worried that I’m not having normal reactions to negative things in my life. For instance, I don’t feel angry or sad when I’m supposed to. Obviously, I don’t mind not feeling so bad but I worry that this isn’t normal. I don’t want to feel depressed but I don’t want to feel numb to real pain either. My husband thinks it’s because I’m drinking coffee too. But, I barely finish a cup in the morning. I don’t feel jittery. I just feel high. And, of course, I really like it at times. Is this a normal reaction? I will be seeing my doc soon to discuss these issues but thought I’d ask here to see if anyone else has felt the same.

  29. The doctor has put my other half on fluoxetine 60mg a day but since she been on them she a different person ??? Gone of with our 9 month old baby and got a flat ??? It’s like talking to a stranger. She just doing rash things and just seems Hi. She also always yawning and I don’t know what to do because I think it just masking the problems she had in the first place as she always suffered with depression as she was on 20mg a day. Is this normal ???

  30. Hello Clark. I’d suggest that you make a phone call to your prescribing doctor and request an individualized tapering calendar ASAP. Alternately, you can contact your local pharmacist and request standard tapering protocols. Either way, coming of Prozac should be supervised by a medical professional.

  31. I am having nothing but trouble coming off Prozac, I hate it, and no longer want it in my system.
    Please help me, is this something I can come off by myself or would I require medical confinement.
    Please I am at the end of my rope here, and have too much to lose if I don’t get help.
    Thanks for your time,

  32. what happens if you are to overdose on prozac? Is it possible or can results be dangerous? what syptoms would occur if overdose were to happen?

  33. Have been on fluoxetine for approx ten yrs. I decided to come off it gradually over a period of three months & do not take it any longer but I now find I’m gettin horrible buzzing type feelings in my head & dizziness. It only lasts a few seconds but is quite unnerving. Shud I be concerned or is this a type of withdrawal ?

  34. Hi Da’Nyce. You are not alone! There may be some underlying emotional issues you can talk out with a counselor. I’d suggest that you call a pharmacy and talk with a pharmacist about possible interactions that Prozac has with pain medications. You NEED to know. Also, ask for more details about when Prozac starts working. And then, talk with you doctor about referrals for a psychologist. You can get help, and you can feel better!

  35. Hi,

    I just started on a 10mg regimen today and, I guess my question would be… How long does this medicine take to really take affect?
    Also does this medicine interact with the narcotics that I frequently take. The narcotics are not prescribed to me but I need them very badly at times- I have such a bad back and arthritis but I am scared to get them prescribed to me because I abuse the Narcs…I can’t go thru anymore withdrawals and if I take them for more than 4 days no matter if I only take like say, 2 percs a days, OMG… I get so ill and I don’t want to go on in life anymore…
    So, when I take Narcs I get the feeling of being happy and peace, calmness, just overall a sense peace…. I am a very depressed person and have been since I was maybe 13… My mother just never got me help – I even told her on several occassions that I was in fact depressed…. I think that if I had gotten the help I need back then, my life would be much better… maybe I would NOT be a struggling single mother of one, can’t really keep a job…etc… and a narcotic junky (well used to be but not so much now)…
    Anyway, I am really hoping that the prozac works, I can’t keep going on like this… I should have a least 5 happy days out of a month and be able to really interact with my daughter… I am so ashamed and I pray to God that this medicine works… I don’t wanna keep waking up feeling empty inside and wondering why God keeps waking me up to this horrible life everyday!

  36. Hello amaryllis. Thanks for your question. The first thing that you can do is to address your concern directly with your husband. Get a feel for what he thinks, and why he is using Prozac, and if he wants to stop. Try to verify the amount of Prozac that your husband takes. Either ask your husband directly or find out on your own. Then, you can consult a family doctor where you live. Although many countries still do not have an understanding of addiction or addiction treatment, perhaps there is something that you can learn about local resources and get an opinion from your doctor.

    But you need to know that you cannot change your husband or his behavior, whether he is addicted to Prozac, or not. He must want to stop himself. So, with this understanding you can seek help for yourself to learn more about what you CAN change (yourself) by seeing a psychotherapist, joining a 12 step group like Al-Anon, or reading self-help books on relationships or communication, or whatever it is that is going on with you. This may seem counter-intuitive, but if you decide to stay with your husband and he IS addicted to SSRIs, you need to be prepared for acceptance and tolerance.

    How does this sit with you?

  37. Hi,
    My husband started taking large amounts of prozac in january. There are no real prescription laws in this third world country we live it, so he freely buys it whenever he wants without a prescription. I’ve been noticing severe muscle twitching, light sleeping and severe sweating. Is he addicted? what should I do?

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