Can you get high on trazodone?

Trazodone is a psychoactive substance. But trazodone effects do not include euphoric high. So, no you cannot get high on trazodone. Review other trazodone effects on the central nervous system here.

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No. You cannot get high on trazodone.

The FDA has no record of reported cases of euphoria after taking trazodone. (Similarly, there is no such thing as an ibuprofen high.) But trazodone does act on the central nervous system. Learn more about trazodone effects here. Then, leave us your comments, feedback or and ask your questions about trazodone at the end!

Trazodone chemistry and use

Trazodone is usually prescribed to treat depression. But trazodone can also be used to treat insomnia and schizophrenia or to control abnormal, uncontrollable movements caused by other medications. Chemically, trazodone is an antidepressant chemically distinct from other antidepressants. Trazodone is in a class of medications called serotonin modulators. Trazodone works by increasing the amount of serotonin in the brain, which helps us maintain mental balance.

Trazodone and central nervous system effects

Trazodone can cause central nervous system depressant effects, but not brain wiring addiction changes, like other prescription drugs.. But scientists do not yet know exactly how trazodone acts on the brain and body. What we do know is that trazodone may make you drowsy and affect your judgment. If trazodone impairs your ability to perform activities requiring mental alertness or physical coordination (Ex. operating machinery, driving a vehicle), you should not drive or operate machinery while taking it.

Adverse nervous system effects usually occur during the first few weeks after you start taking trazodone. The most frequent adverse effect associated with trazodone therapy is drowsiness. Other less frequent adverse nervous system effects of trazodone include:

  • anger
  • confusion
  • decreased concentration
  • delusions
  • disorientation
  • dizziness
  • drowsiness
  • excitement
  • fatigue
  • fullness of the head
  • hallucinations
  • headache
  • heaviness of the head
  • hostility
  • insomnia
  • impaired memory
  • impaired speech
  • lack of coordination
  • lightheadedness
  • malaise
  • nervousness
  • weakness

Mixing trazodone with other substances

Trazodone may enhance your body’s response to alcohol, barbiturates, or other central nervous system depressants. Trazodone can also react with other medications and produce many unwanted and potentially dangerous side effects. This is why doctors recommend that you list all herbal supplements, medications, and treatments and share them with your prescribing doctor or pharmacist before you start taking trazodone.

If you are in need of treatment help for antidepressant withdrawal, you can get better prepared for what to expect during the detox process by learning what it entails.

Trazodone use questions

Please send us your feedback, comments or questions about trazodone below. We would love to hear from you and will refer you to information the best that we can!

Reference sources: State of California Bureau of Forensic Services Drug Summaries
Daily Med drug info on trazodone
Hazardous Substances Data Bank Human health effects info on trazodone
American Society of Health System Pharmacists info on trazodone
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. I usually take 200 mg trazadone half hr prior to my 93 mg of methadone & sumtimes I take 30 mg of dextromethorphan on top of that. I don’t recommend that to anyone,yes I do nod like crazy.
    However like I said,”I don’t recommend that to anyone.”
    I obviously am an old head to drug ab use. Take my word for it my health is in the toilet.
    Please go slow & take it easy!

  2. I often get high using trazodone. My vision greatly distorts, leaving two dimensional screens to be a little pop-up like, and focusing the space around me differently, as in bending shapes. Also, it leaves me with a feeling close to being drunk, with a slowness of the thoughts and slight dizziness/disorientation. I tend to either find things pretty amusing or not have the ability to care about them, I’m so focused on the “drunk” aspect. But no specific “spike” euphoria, or euphoria at all usually.

    1. Hi Luna. It is interesting to learn about your experience and the effects it has on you. Thank you for sharing, and without tending to sound too preachy, please be careful, especially not to mix it with other substances.

  3. i get a euphoric high when i take at least 300 half way through a meal sort of a pulsing buzz throughout my body if you fight the urge to sleep you will get high.

    this is for informational purposes only based on what ive experienced where i have a prescription for the 150s

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