Does Fentanyl get you high?

Yes, Fentanyl can get you high. In fact, this opioid synthetic drug can absolutely be abused and produce an intense but short-term high, similar to heroin or other opiate painkillers, but much, much stronger. More here on how Fentanyl woks (and its dangers) with a section for your questions at the end.

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What is Fentanyl?

Fentanyl is a strong opiate pain reliever that is similar to but much more potent than morphine. It is typically used as a post-surgical pain reliever, or in situations of severe pain.

However, Fentanyl is classified by the Drug Enforcement Agency (DEA) as a Schedule II drug, meaning it has some medicinal value but high abuse potential. Further, a synthetic version of this drug is now being produced in illicit drug labs – known as acetyl Fentanyl – has no approved medical use but is just as addictive. On the street, this drug has been called Apache, China girl, China white, dance fever, friend, goodfella, jackpot, murder 8, TNT, Tango, and Cash.

So, are people using Fentanyl to get high? How does it work in the brain? We review here. Then, we invite your questions or comments about the euphoric effect of Fentanyl at the end.

How Exactly Does Fentanyl Work?

Fentanyl, like other opiate pain-relievers, attaches itself (or “binds”) to the opiate receptors in the brain. These receptors are highly concentrated in the parts of the brain responsible for pain and emotion. The drug works by selectively binding to the mu-receptor in the central nervous system, thereby mimicking the effects of opiates that naturally occur in the body. The result is a change in the amount of neurotransmitters in the brain cells, especially of dopamine, thus producing a  potent “high” feeling of euphoria.

However, it also has an effect on the parts of the brain responsible for some autonomic functions such as breathing. The main deadly mechanism of any opiate drug is the depression of respiration- essentially, an overdose can cause the user to stop breathing, which leads to brain damage and death if not reversed in time.

How is Fentanyl Used?

As mentioned, Fentanyl is a highly potent opiate painkiller. It is officially used for pain relief, to be prescribed by physicians. When prescribed, it is typically administered via injection, patch, dissolvable lozenge, or even in a “lollipop”. However, there is an increasing trend of illegal use and abuse of this drug.

Illegally produced Fentanyl tends to be in powdered form, and more often than not is mixed with heroin. Users trying to purchase heroin often unknowingly purchase a mix of the two, and wind up overdosing as a result. The patches are also frequently abused or used incorrectly, typically leading to a Fentanyl overdose or death.

What are the side effects of Fentanyl?

Main side effects of Fentanyl include:

  • difficulty urinating
  • drowsiness
  • dry mouth
  • intense euphoria
  • lightheadedness
  • respiratory difficulties
  • severe constipation
  • weakness and fatigue

Can Fentanyl Get You High?

Yes, Fentanyl can get you high.

In fact, Fentanyl can absolutely be abused and produce an intense but short-term high, similar to heroin or other opiate painkillers, but much, much stronger. Getting high on the drug is one of the main reasons for abuse that leads to addiction, and once addicted, individuals require structured Fentanyl addiction treatment programs and help to stay clean and sober on the long terms.

Another major danger is, Fentanyl is anywhere from 25-40 times more potent than heroin, so even “experienced” opiate users can easily overdose from Fentanyl, particularly when they aren’t aware of how much they are taking.

Despite the dangers, more and more opiate users are turning to  heroin for a more intense or “better” high. However, the unpredictability of this drug in terms of potency and absorption rate makes it a serious risk for both overdose and death.

Fentanyl Danger on the Rise

Opiate overdoses either directly involving or including Fentanyl as a contributing factor are, alarmingly, on the rise. While most toxicology tests cannot differentiate between illicitly-produced Fentanyl and prescription Fentanyl, the CDC reported that between 2013 and 2014, deaths involving Fentanyl (or related opiates) increased by around 80%…and the numbers continue to rise. Law enforcement continues to observe increasing numbers of illicitly produced Fentanyl in reported seizures, which is likely contributing to the rash of deaths in recent years.

What to Do In Case of Fentanyl Overdose

Call 911 immediately.

Timing is critical, as any opiate overdose typically means breathing has stopped, and the longer you go without oxygen, the higher the chances of brain damage or death. Paramedics and police officers can administer life support, and should also be equipped with Narcan, medication which reverses the effects of opioid overdose (including sedation and respiratory depression).

Further, more and more civilians are being trained and equipped for administration of Narcan – you can contact your local department of health for more information on this training. Finally, even if Narcan is administered in time, this is only the first step.

Don’t Stop at Narcan

Drug overdoses are rarely isolated events. Substance abuse detox and treatment should be sought immediately to prevent continued use, and to decrease the likelihood of additional overdoses. When you are stuck in a cycle of prescription painkiller addiction, it can be difficult to imagine that life could be any different. However, people do recover from opiate addiction every day, and go on to live happy, productive lives.

Reach out, help is available.

Questions about Fentanyl

Do you still have questions about the euphoric effect, the high, or the risks of taking Fentanyl? Please leave us your questions in the comments section below. We’ll do our best to respond to you personally and promptly.

Reference Sources: National Institute on Drug Abuse: Drugs of Abuse FENTANYL
WebMD: (
Centers for Disease Control (CDC): Increases in Drug and Opioid Overdose Deaths — United States, 2000–2014
PubChem Fentanyl Description
About the author
Heather King, Ph.D., completed her graduate studies in preclinical substance abuse research in July of 2015. She has authored several peer-reviewed publications in scientific journals on the effects of drug abuse on the brain and behavior, and has personal experience in addiction and recovery. She currently works at Serenity Acres, a drug and alcohol treatment center outside of Annapolis, MD.


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  1. You should fix the typo in the first paragraph. Does it work by “blocking” or “increasing” the amount…

    “The drug works by blocking increasing the amount of dopamine in the brain, thus producing a “high” feeling of euphoria.”

    1. Hi Daniel. We checked the text, but could’t find this sentence. Is this the right article? If not, could you please comment on the right one. We would greatly appreciate it.

  2. Hi there,
    Was wondering if you could help me. I know what opioid addiction can do to individuals as I come across alot of overdoses in my profession. But I have a very close friend who I think may be either smoking fentanyl or something else. I have no proof but I’m extremely worried. She has had addiction issues in past. She goes into bathroom for long periods of time and you can hear inhaling something and holding her breath, and the odour that comes from whatever it is she is taking is quite different. And one minute she is talking to you and then she is completed passed out on the toliet. I guess I’m wondering what type of state would fentanyl or crack put someone into directly after ingesting it? Do they pass out?

  3. I was wondering. My pain management doctor has recently changed my pain medication from ms contin (morphine) 60 mg ER 2x a day to 50mcg of fentanyl patch every 3 days. Ive had 2 neck surgeries and a shoulder surgery in all in the past 2 1/2 years. What should i be concerned about ? I know heroin destroys your heart and arteries so does fentanyl do the same thing since its just like heroin but stronger. Ive been worried about it ever since i started the fentanyl patch 4 days ago.

  4. I hope that you can answer my question. I have used opiates for over 30 years and recently there has been a lot of bad press about fentanyl but I have never got a hit from it. Its definetly not because I have a tolerance to opiates or that the stuff I have taken isn’t fentanyl. I just don’t understand why it has no effect on me. Please can you explain. Many thanks.

    1. Hi Sam. It seems to me that fentanyl doesn’t work because of your tolerance to opiates. Moreover, I suggest that you use fentanyl only as prescribed.

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