How long does Fentanyl stay in the system?

It can take your body several days to eliminate Fentanyl. How dangerous is Fentanyl and what does detox from Fentanyl feel like? More here.

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Reviewed by: Dr. Dili Gonzalez, M.D.

When used by medical professional, and as prescribed, Fentanyl can be an effective means of treating chronic or extreme pain. However, it’s effectiveness makes it an appealing target for opiate addicts. And Fentanyl is increasingly tested for use as a drug of abuse.

Q: So, how long does it take for the body to eliminate Fentanyl? How long can it be detected in drug tests?
A: Fentanyl can take anywhere from a day to two days (or sometimes more) to leave the system.

Continue reading to learn about Fentanyl’s duration and addictive potential. Your questions are welcomed in the section at the end of the page, and we try to answer personally, as soon as possible.

What is Fentanyl, and is it dangerous?

Fentanyl is a Schedule II opiate medication, meaning it has some medicinal value but also possesses a high risk for abuse. It is intended for use with pain relief in hospitals or for patients with chronic and severe pain issues. However, the opiate epidemic has turned Fentanyl and its synthetic analogs into lethal threats comparable to heroin and other street drugs.

Fentanyl and illegally-produced Fentanyl copycats have acted as gasoline on the fire of the opiate epidemic. Fentanyl is 50-100 times more powerful than morphine, and 30-50 times more potent than heroin itself. This puts even experienced heroin users at risk of Fentanyl overdose if taken in excess. Further, in “street mixes” of heroin and Fentanyl, oftentimes the ratio of Fentanyl to heroin is totally unknown, which could also lead to overdose.

Fentanyl and Fentanyl-laced heroin have many street names, including Apache, China girl, China white, dance fever, friend, goodfella, jackpot, murder 8, TNT, Tango, and Cash.

How does Fentanyl work?

Fentanyl activates the opiate receptors in the brain, particularly in areas of the brain that process emotions and pain sensitivity. Does Fentanyl get you high? When you take any opiate, including Fentanyl, it increases the amount of free-floating dopamine in these parts of the brain, producing a “high” feeling, or sensation of euphoria. However, it also seriously affects the parts of the brain responsible for some critical life functions such as breathing and heart rate. The way that opiates cause death when taken in excess (i.e., overdose) is the depression of respiration- essentially. An overdose can cause the user to stop breathing, which leads to brain damage and death if not reversed in time.

How long does Fentanyl stay in the system?

In general, the answer to this question depends on a host of factors:

  • How much Fentanyl has been taken
  • The route of administration
  • How long of a time period it has been taken for
  • Subjective factors such as height, weight, gender, general health, and drug history

If Fentanyl has been administered intravenously (IV), for example, it clears from the body’s system much faster than if it has been taken transdermally (i.e., the patch) or transmucosally (i.e., lozenges). IV Fentanyl is usually cleared from the body in roughly 11-22 hours, depending on the other interacting factors.

Other administration methods can take up to a day and a half or two days.

However, as Fentanyl breaks down it leaves behind traces called “metabolites”, and these can be shown in plasma or urine screens for an even longer period of time. This means that a particularly thorough drug test could detect use even after several days of “staying clean”.

Is there a way to rapidly detox from Fentanyl?

There are some facilities that advocate for “Rapid Detox”, which is typically anesthesia-assisted withdrawal. The patient or addict is sedated under medical supervision while they are put into immediate medical withdrawal from a drug by use of an opiate blocker. However, this procedure can be expensive and is rarely covered by insurance companies. Further, studies have shown that this method does not produce any significant reduction in withdrawal discomfort compared to any other methods.

What is Fentanyl detox like?

Like any other opiate, detoxing from Fentanyl is not a pleasant experience. When medically supervised, detox is typically safe, and many side effects can be alleviated with other medications. When do you start withdrawing from Fentanyl? If you’ve developed dependence on Fentanyl, you’ll begin withdrawal close to your next expected dose n the first 24 hours after last use.

Additionally, if an addict is detoxing in a non-medical environment, without proper care and assistance, the symptoms can be severe and debilitating. When your body is used to receiving any drug on a regular basis, it can develop physical dependence, meaning the removal of that drug “throws off” the body and creates a host of unpleasant symptoms. Fentanyl withdrawal can cause:

  • chills
  • extreme nausea
  • gastrointestinal cramping
  • insomnia
  • irritability
  • muscle and bone discomfort or pain
  • restlessness
  • severe anxiety
  • sweating

Questions about Fentanyl?

You can learn more about Fentanyl Addiction Treatment programs and help options if you or a loved one are in need of professional medical assistance. If you still have questions about how Fentanyl affects the body and can be traced…please leave them in the comments section below. We’ll do our best to respond to you personally and promptly.

Reference Sources: DEA: Drug Chem Info for Fentanyl
DEA: Drug Diversions
NIDA: Withdrawal not easier with ultrarapid opiate detox
Mental Health Daily: How long does Fentanyl stay in your system


About the author
Heather King, Ph.D., completed her graduate studies in preclinical substance abuse research in July of 2015. She has authored several peer-reviewed publications in scientific journals on the effects of drug abuse on the brain and behavior, and has personal experience in addiction and recovery. She currently works at Serenity Acres, a drug and alcohol treatment center outside of Annapolis, MD.
Medical Reviewers
Dr. Dili Gonzalez, M.D. is a general surgeon practicing women's focused medici...

All of the information on this page has been reviewed and verified by a licensed medical professional.


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  1. Hello ok so I have used June 6th last time and it was sold as H to me and I am on methadone and have bin clean for a long time but anyways I was on full carrys and if I use 3 days later anything is gone but now this fentanyl I tested positive upto June 21st for it still and I switched do toes and clinics because I thought the first place was lieng to me or getting my file messed up with someone else’s and now the next new clinic 15 days after usage told me I was still dirty and the college of physicians for British Columbia Canada have a thing posted that fentanyl can be detected in urine upto 10 to 15 days now they updated their website that makes it real show your doctors this place is the place that teaches the methadone doctor’s in Canada and its real

  2. I am a chronic pain sufferer with 8 herniated disks, severe spinal stenosis, and osteoarthritis of th’e spine. My pain was being managed with 100mcg Fentanyl Patch and 15mg oxycodone 3x daily. With all the negativity and the DEA I was reduced to 75mcg Patch and recently it was replaced with a new drug Xtampza 36mg 2x daily. It does not relieve my pain and I have asked for my patch back many times. The patch allowed me to be functional and lead a semi normal life. I could DO things like gardening and household cleaning. Without it I can’t DO the same things. It is difficult for me to even complete a grocery order. I never abused my patches and changed them every 72 hours as directed. I did not make this opioid epidemic and I am sick to death of paying the price for it. Some people such as myself need this drug to have some quality of life. In addition, I have been without any long term medication due to my pain management not filing the prior authorization required by my insurance. I am in severe pain and feel like no one even cares. What’s happened to our medical society?

  3. I have to take a drug test and a urine drug test and I shot heroine they had that not in it I did a 60 bag how long will that stay in my system and is there anything I can do to make it leave my system faster drink lotta water what can I do?

  4. 4th day off 25 mg fentanyl patch been on lil over a year. Went cold turkey. Never abused. How much longer do the w/d last? I have klonopin muscle relaxers prescribed. Taking prescribed anti inflammatory. Plus Tylenol. How much longer to expect my body attacking its self?! Thank you so much

  5. I’d forgotten about this post until the recent post had reminded me. Sorry, Carl; I don’t have an answer to why they picked up metabolites, a week after use. During my use of the drug, I seen my fiancee go into withdrawals while using more than I did, at the time and I was still capable of taking care of her for several days after I quit using all-together before going into withdrawals myself. Before then, i was using around 5000 mcg daily to her 1000 – 2000mcg daily, via nasal spray for almost 18 months, so i assume it builds up over time but she did weigh 98 lbs to my 180lbs so metabolism more than likely plays a part. We’ve been clean for 4 months now and have only started getting our natural energy back in the last 6 weeks. Before then, I couldn’t go outside without the sun burning my skin through my shirt and I worked construction, so I had to quit because of it. We actually got pregnant right after quitting because libido is the FIRST thing to come back, even though sex only lasts 10 seconds. We’re out of work because of that awful drug and are broke and hungry but I feel better than I have in years, even though I think about fentanyl daily and catch myself occasionally trying to clean my old bottles to try and get a hit to help with sleep, which is still almost impossible without sleeping pills. My advice for anyone getting into fentanyl for the first time is distance yourself from it by as much as possible and if you’re trying to quit, set alarms for every few hours to tell you when to use. It helps you gain control over the addiction, so you tell your body when you’ll use, instead of your body sending messages to your brain, telling you when to use because it’ll trick you into thinking you’re detoxing, when you’re really not. Every week, change your alarms by one hour more until you’re low enough to quit. I could never stick to this regiment because I couldn’t talk my fiancee into following it, so everytime she’d use, I would but it was my lack of willpower that hurt me the most. We hurt ourselves in the end, while watching each other go into violent seizures and hallucinations while the other couldn’t do anything to help. Good luck to everyone trying to get off of it and there is hope.

  6. Like a dumby I used heroin that had fentanyl in it, I had to leave a urine sample at my methadone clinic and came up positive after 7 days, how is that possible.

  7. They say Fentanyl leaves a person within 2 days. Does that also go for if the person passed away from Fentanyl? How does the drug pass through or out of your system?

    1. Hi Deirdre. If an autopsy is made on time, there will be traces from Fentanyl. I suggest that you consult with a coroner or another professional about your issues.

  8. you said metabolites could be detected within several days, define several, does that mean 10 or 20 maybe 30 days after with a thorough drug test?

    1. Hi Dan. It really depends on a person’s health state, the used dose, metabolism, level of hydration, body mass…etc. There are simply too many individual factors to precisely define the time period until complete elimination.

  9. I was im the hospital for aorta repair heavily sedated with pca pump and epideral went to pjysh dr today got an imstant urine drug tesy said o was + for numerous meds that i never took in my life could this be from my hospital stay that i was released a month ago

  10. I am on 75 mcg Mylar patch after failed back surgery 6 years ago. I desire to get off this evil medication as it has taken my life away. It has taken the pain, and with my life with it. I am empty and find life difficult. I can not sleep, and I worry about everything all the time. Please help.

    1. Hi Wilbur. Call the helpline you see on the website to speak with a trusted treatment consultant who can help you find the best treatment for you.

  11. I used to be a heavy iv user of heroin/fentanyl. I have stopped using and i am now in the methadone clinic. I have not used since may 22, 2017 and i have taken a urine test on may 31, june 15, 19 and 23. And they all have shown up with fentanyl in my urine still. Can someone please help….my freedom is on the line…..thank you

    1. Hi Julz. Do you take any other medications/food that may cause false positive? For instance, poppy seeds (added to cakes, bagels, and other pastries) can contain traces of opiates and cause a false positive opiates for as long as two days after consumption. Moreover, keep in mind that detection window in longer for heavy and long term users. Finally, if you want to learn more about drug testing, download our free e-book ‘The Definitive Guide To Drug Testing:

  12. I am in the Methadone clinic and they recently started testing for fentanyl. I hadn’t used anything containing the drug in over 15 days and I had a positive uds for it. I also know of several others at the clinic who this has happened to. We all have hepatitis c. That could be the underlying cause of the slow metabolism of the drug, but we are all being chastised and accused of using by the doctor s and the staff, because no one there believes us that it would stay in the body that long. We can’t believe it, either, but I know that I haven’t added anything to my body but methadone . It is very confusing and discouraging. Any answers???

  13. A hair sample was taken for testing today, alcohol & drugs- I have had a few beers over a 3 month period- no hard liquor. Do you think it will show up in the results?

  14. Do not use the oral spray fentanyl or as some call it inhaled fentanyl!! I’ve been on Subsys (fent oral spray) for about 1.5 years due to severe chronic pain following multiple failed surgeries. I think I started out with 200mcg spray, and my highest dose was 1200 mcg oral spray. My pain dr pressured me to try it and sang praises about its pain relief. Come to find out recently that nearly all his patients are on it (seems fishy to me, like he’s getting some kinda kickback). Also, his office can’t fill prescriptions on time, so I ran out early several times & went into days of withdrawal until I got my next prescription sent by the specialized pharmacy. Ya, that’s right you can’t get this form at the regular pharmacy; only a few specialty places have it. This last time my dr left me in a lurch, I decided enough is enough! I detoxed off this nasty drug at home (without suboxone), it was 8 days of sheer agony with all the symptoms in your article (except irritability) and I had new sneezing fits and depression too; this was followed by a few more days of moderate (but improved) nausea and headache. I’m still having insomnia, though it’s improved since the detox period. It’s scary what an effect this Med had on my body and how strong it it. I wish I’d have researched it before taking. If I’d known it’s stronger than heroin and cocaine, I’d have passed on it.

  15. Is there a psychiatric medication prescribed for the suicidal thoughts piece of withdrawl. I am a Chronic pain person who reduced from 75 down to 62.5 mcg transdermal patch every other day.

    Too bad they can’t put people in medical induced coma for complete detox.

    1. Hi Eileen. I suggest that you consult with your doctor about this issue. Also, you may call the helpline on the website to speak with a trusted treatment consultant. Moreover, call the National Suicide Prevention Lifeline on 1-800-273-8255 get in touch with professionals who can help in suicidal crisis or emotional distress.

  16. I had a UDS at my Methadone clinic today. I am on 22ml of Methadone, I did have a benzo in my system as dentist prescribed it for a dental appointment as been having major work done and I have an anxiety disorder especially heightened attending dental appointments. I smoke marijuana occasionally as it helps with my anxiety and my physician is supportive as she would prefer this opposed to benzodiazepines as they are not safe when on Methadone she states, potentially fatal. I was clean from cocaine, heroin, crystal meth and amphetamines as expected but I had a positive for fentanyl?!?!?!? How is this possible could fentanyl have been added to my marijuana?! The clinic staff stated they have heard of this now happening… please help my disability company will cut me off benefits if any illicit or unprescribed drug is positive in my UDS. Thank you

    1. Hi Storm. Your marijuana may be laced with Fentanyl. However, there are many other things that may cause false positive. For instance, poppy seeds (added to cakes, bagels, and other pastries) can contain traces of opiates and cause a false positive opiates for as long as two days after consumption. If you want to learn more about false positive, download our free e-book ‘The Definitive Guide To Drug Testing’ here:

  17. Hey i am 14 i have questions about withdrawal and charges when one
    consumes ¨fent ¨’ not because i use it just for a school project

  18. I was gave patch’s for very bad pain the 4th patch put all 3 day suppli into my body that has been over 2 months ago now after 3 hospital trips never could get my heart rate up they put a pace maker in after blacking out many times plus many more very bad problem like hearing is gone eyes giving me problems , lungs are not good even close as let and Mylan the maker just don’t care. Please stay away from these very bad things

    I was told to use these for very bad back pain now my DR. AND myself wish we had never heard of this. After 4 hospital stays the last a pace maker after the Fentanyl patch put all in me for 3 days all at the same time this a killed the then Has MYLAN CARED AT ALL NOT ONE BIT! The pace maker got the heart rate back up were it was before I don’t black out any more. Bujt still dealing with many more side adfects that are very bad losing hearing ,my eye sight nerve probems But good old Mylan would not have cared if it would have killed me the way I fell I would not have either living like this is not fun Douglas

  19. I am withdrawing from phentanl from being on it for 3years,,cold turkey due to my doctor realizing me from her practice because I got my apt day mixed up…I found a doc . And then went to a pain clinic,,they will not administer meds until my urine test comes no phentanl…. hso my doctor gave me 10 mg of oxy/ acetaminophen,,I take it when I feel I can’t take it any more,,3to 4 times a day,,is this drug the same as phentanl, please,please reply,,,,I have been taking it 3fimes a day..I want off these meds,,I’m on these due to cervical pain from motorcycle. Accident..I have had cervical rebuild from 4 to7.p ins plates cadaver bone,,,,,this has been the worst nightmare ever,,thank you,carrie

  20. Hi i am an IV user and desperatly want to quit. I know what im getting these days is more fent than anything if not straight fent. I have suboxones to do this but have been told by several people that the subs didnt seem to work or that they caused their withdrawls to be even worse even tho they waited over 24 hours to take it. Could this be because of the fentanyl? If so, how long should i wait to start the subs to avoid these worse withdrawls? Will the subs even work for withdrawls from fentanyl? I know your gonna say it depends on how much i am using and the answer to that i would say i do half gram to a gram per day

    1. Hi Rikki. I suggest that you consult with your doctor before making any changes in your medications.

  21. I was on 150mcg/hr Fentanyl for over 25 years due to 5 back surgeries. I took my last patch on February 16th 2017. I now am using 5mg Oxycodone 4xday. I feel like I am still withdrawing from the Fentanyl. After so many years is the Fentanyl in my bone marrow and will it take months to get rid of all of it?

    1. Hi Margaret. You’ve build up a tolerance to Fentanyl. It needs time for your body to adopt the new fentanyl-free environment. I suggest that you speak with your doctor about all concerns you have with Fentanyl. Also, consult with a pharmacist to recommend some over-the-counter aid, herbs, teas, etc to ease withdrawal symptoms. Moreover, here’s suggested reading on the topic:

  22. Have been on Fentyal 150mcgs for 15 years and want to end this cycle. I’d rather live with pain and feel alive for the rest of my life. As it is I live to make sure I have my medicine each month and it’s driving me nuts. Any suggestions?

  23. I was given fentanyl when I was in the hospital after the procedure that I had. After I was in recovery I had severe abdomen pain very excruciating unbearable and they gave me Fentanyl this drug didn’t take the first time they gave it to me so they gave it me more I don’t know how many milligrams but the next day I came home and I had all the symptoms that you have laid out there and I’m still having those symptoms I need to know how long it will take me to get this out of my system because I can’t I won’t and I don’t want to liver disease symptoms.

  24. I was gave fentanyl patch for very bad back but 4th patch was defective and put the full 3 day dose in my body have many health problems from this the worse being a cough that will not stop i turn blue just will not stop at times it makes me sick, this id one of many things many times close to death and many times as bad as i am wish i would have died the night it happened please help

  25. My daughter was in a residential program for fentanyl use. She was drug tested (urine) 7 days after arrival and tested positive yet swears on her son’s life that she did not use. Is this possible? Is it possible for these traces of metabolites that you say stay in the system even longer be enough to cause a false positive 7 days later? Is a drug testing facility able to distinguish between usage and residual metabolites?

  26. I went into detox march1 I used fentanyl Day before. Now I took a drug test march 7th and today my doctor said I had traces of that drug when I tested on 7th. How is this possible?

  27. Best and fastest way to clear body from herion and fentaly for urine test. How to detox . Any home remedies?
    Plz and thx.

    1. Hi Michael. Call a toll-free Heroin Helpline on 1-888-988-7934 to get in touch with trusted and confidential helpline professionals available 24/7. You will speak to a sympathetic, well-trained individual who can help you find a reliable recovery program that will meet your treatment needs.

  28. I am a IV user of heroin and am dealing with it being palluted with fentanyl they put it in the heroin because it’s more addicting and it makes week heroin stronger it’s cheap and I am on the methodone as well and get urine tested every week to get a home carry for the week I see my doc on tues leave a sample of pee then I use heroin Tuesday and Wednesday but can’t use any more or it will show in my next weeks pee test so it’s safe to say it’s all cleaned out of my system heroin and fentanyl by Tuesday morning the peaple on methodone seem to be not as effected (dying) as those who aren’t the methadone cuts down on the effects but is still very risky

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