Wednesday September 28th 2016

Trusted Helpline
Help Available 24/7
1-888-882-1456
PRIVACY
GUARANTEED

How long does buprenorphine last?

Buprenorphine is a prescription drug that helps address cravings and delay withdrawal symptoms for those facing opiate and opioid addiction. If you have been prescribed a dose of buprenorphine, you may be interested in how this medicine works and how long buprenorphine can remain in your system.

Here, we review how long buprenorphine lasts – how quickly buprenorphine works, its duration of action and its time in the system. Then, you will have a chance to ask your questions about buprenorphine at the end.

Buprenorphine effects on the body and brain

Buprenorphine is a semi-synthetic opioid used for the treatment of opioid or opiate addiction. Buprenorphine is also used to treat moderate acute pain. Buprenorphine is a partial receptor agonist and acts in a way that attaches to specific sites in the brain to inducing several effects. However, the binding process is not “perfect” and buprenorphine occupies central nervous system receptors without causing the euphoric effect of other stronger drugs. In fact, this is the reason why buprenorphine is used in opioid addiction treatment. These main effects of buprenorphine can include:

  • constipation
  • nausea
  • pain relief
  • reduced cravings for opiates or opioid class drugs
  • slower breathing
  • slower heart rate
  • suspension of opiate withdrawal symptoms
  • vomiting

Buprenorphine duration of action

Buprenorphine has a half-life of 24 to 60 hours, depending on the route of administration and whether it was used in combination with other drugs. Additionally, buprenorphine has the ability to stay and bind the opiate receptors for over 24 hours, effectively disabling the receptors to make use of other stronger opiates less appealing. For these cases, user cannot not get high on drugs like heroin, morphine, codeine, hydrocodone, or oxycodone.

Buprenorphine time in the body

Buprenorphine is eliminated by the urine and feces. Over 30% of buprenorphine is excreted by urine and more than 69% excreted by feces within a range period of 11 days after administration of sublingual tablets of buprenorphine.  In fact the elimination half-life may vary between 20 to 73 hours.

How long do buprenorphine effects last

Buprenorphine has different performance and effects depending on the form that is administered. For example, buprenorphine has very poor bioavailability when administered orally, in the form of solution. On the other hand, buprenorphine sublingual tablets trigger moderate bioavailability. When patients are followed starting from the initial dosing period, later in treatment they very often do not manifest euphoric effects even after extensive doses of buprenorphine are administered. Such cases are evidence that tolerance level can change the way the drug acts in the central nervous system.

Trusted Helpline
Help Available 24/7
1-888-882-1456
PRIVACY GUARANTEED

The sublingual tablets are meant to be put under the tongue in order to gradually dissolve with the saliva and contain 2 mg buprenorphine with 0.5 mg naloxone and 8 mg buprenorphine with 2 mg naloxone. Users claim that there is a difference between sorting crushed tablets of buprenorphine and oral administration of the same amount.

How long does a buprenorphine high last?

The euphoric effects of buprenorphine will also depend on the level of tolerance that your body has developed toward buprenorphine. It is mots likely that the euphoric effects will wear off after 8 to 12 hours. Pay attention though: this number would be different if you are chronically taking buprenorphine for recreational purposes.  Many users will go that far and change buprenorphine for other painkiller on their own, without a doctor’s recommendation to do so, and then experience different effects than mentioned on the product label.

Buprenorphine high effects

Here is a list of the most common buprenorphine effects which can accompany euphoria:

  • constipation
  • difficulty breathing or swallowing
  • difficulty falling asleep or staying asleep
  • extreme tiredness
  • headache
  • hives
  • itching
  • lack of energy
  • loss of appetite
  • pain in the upper right part of the stomach
  • skin rash
  • slowed breathing
  • stomach pain
  • sweating
  • unusual bleeding or bruising
  • upset stomach
  • vomiting
  • yellowing of the skin or eyes

Buprenorphine duration questions

We hope we’ve been able to address your questions about buprenorphine above. If you would like to know more about how long buprenorphine lasts, please ask us in the comments section below. We try to respond to all legitimate queries with a personal and prompt response.

Reference Sources:  Daily Med: BUPRENORPHINE HCL AND NALOXONE HCL (buprenorphine and naloxone) tablet
NY Department of Health: Buprenorphine
SAMSHA: About Buprenorphine Therapy
SAMHSA: Clinical Guidelines for the Use of Buprenorphine in the Treatment of Opioid Addiction

Photo credit: Didier Jansen

Leave a Reply

34 Responses to “How long does buprenorphine last?
Chuck
5:26 am October 29th, 2014

Hello, im an idiot. I have used norco at a rate of 4-6 times a day for 3 months. I flushed my pills with the idea I could use one 8mg suboxone broken up over 4 days to surpass the acute wd of norco. I’m now worried I have traded a mild wd for an intense bupreborphine wd. I did only take roughly 2mg per day for 4 days, but have read horror stories on the effects. Im hoping you can give me a heads up on what I’m in for. Thanks.

judy
4:18 pm November 1st, 2014

Hello..i am a recovering opiate addict…i was wondering if anyone knows of a walk in subotox clinic in richmond.
I have a friend who is desperately seeking help there!!

11:58 am November 7th, 2014

Hi Chuck. Buprenorphine withdrawal will usually peak in severity and intensity 72 hours after your last dose and gradually become less intense. You can expect diarrhea, sweating, nausea, dilated pupils, watery eyes and restlessness in this period. It will be hard for the first two weeks, but it will be getting better gradually. But, psychological withdrawal symptoms may persist for months. Be ready to get doctor’s help at any time and have someone to drive you there. You can read this article for more info: http://prescription-drug.addictionblog.org/what-is-buprenorphine-withdrawal/

judy
8:14 am November 16th, 2014

I am desperately looking for suboxone or anything that will help me get off dope..
I don’t have the money it takes to pay for all the Dr’s appts.
Northern va area
Someone plz plz advise me

Cecilia
9:02 pm January 5th, 2015

First off I apologize for my pre-conceived idea of what a person addicted to drugs is. We are not uneducated, unemployed, unkept etc. Most live in excruciating pain, have busy lives, work hard, keep families and try to get buy day to day. I started with Fibromyalgia-I know most people feel this illness isn’t real but until a better diagnosis is found, I’m here to tell you the pain can be indescribable. I spend most days laying in a hot bath because its the only way I feel slightly human. I sleep in the bathtub. Then I developed diabetic neuropathy in hands, feet and legs. Now 3 herniated discs in C spine and 2 in lumbar spine. 2 heart attacks-5 stent implants in my heart-finally quadruple coronary bypass and chronic angina. I’m not trying to convince you I have a lot of pain, just giving you my background. I was put on Vicodin in 2001 for my angina, prior to that I was treated with neuronitin, Cymbalta, anti inflammaty drugs, Amrix, lyrica, Elavil, so many others I cant remember. Took 5/500 Vicodin for years until it didn’t work any more. I would run out long before my RX was do and would beg borrow and anything else to get more. I found out about Suboxone in 2007 and got a prescription from a pain doctor who seemed drugged himself each time I saw him. I was on 8mg three times daily. It was wonderful-I never wanted more and it helped immediately especially with my neuropathy. Even when I changed doctors I was told by each doctor it was great for pain-the cost of $450 each month was very problematic. I was finally told by a pharmacist that there was a generic in 2011 and since I was taking it for pain I could use it, the Buprenorphine was covered by insurance with a copay of $10-yea. I had been having extremely swollen feet and legs and hands for sometime. My normally tiny feet and ankles were 3 times the size which my Doctors could not explain and I started throwing up with excruciating stomach pains. My throwing up in volume on a daily basis with the horrible stomach pain sent me to the ER many times by ambulance. Visits to multiple Gastroenterologist and tons of test found nothing. Until September 2014 when I started tracing my swelling and vomiting to the month I started taking the Suboxone in 2007. I also realized that I started with insomnia at that time along with weight gain and loss of libido. I told this to my doctors but was told the Suboxone (Buprenorphine) could not be the problem and they didn’t suggest getting off it since it helped with my pain so much. I think it was a cop-out for them not wanting to change my RX with all the new laws regarding narcotics. In September 2014 I took myself off the Buprenorphine-I took myself off Vicodin and Oxycontin in the past but this was 1000 x worse. It took me a month + of the worse withdrawals I’ve ever been through but the week after I stopped taking the Buprenorphine my swelling went completely away-I haven’t vomited once nor have I had any stomach pains since. I’m sleeping like a baby and have lost 20 pounds and I have a sex drive again. You can’t tell me it wasn’t the Suboxone/Buprenorphine all along. Yes, my pain is back and I’ve been in misery for the last 2 months so I had to go back to Norco but the side effects from the Bups was not worth all the swelling, vomiting and stomach pains etc…. Don’t let anyone tell you it’s easy to withdraw from Buprenorphine and the side effects are few-it’s not true!!

2:16 pm January 12th, 2015

Thank you, Cecilia for taking the time to write your experience and story. I’m sure someone can find it useful and inspirational. I’m glad you listened to what your body was telling you. All the best, Ivana.

Robert
10:58 am April 10th, 2015

I am a full blown addict, have been since 26 I’m now 30. Was prescribed 180 lot tabs 90 bars yor 6 yrs sold Prob 75% took the rest. That doc retired and I found one in my hometown who wrote me 30 30mg oxy and 90 tabs 30xans. Sold the oxy for months only took the tabs then one day I snorteda Roxie!! I found heaven, I dabked with them off and on for a month then went into work one mornin had only taken two tab 10s felt horrible sweating nausea, co worker that bought the ROX laughed and said your with drawing dude! I never felt like that for 6 yrs on opiates, snorted a 30 and wah lah 5 min later I’m superman. That was back in 2010. I list that job because I took to many Rox and xan and drank at a good jobsnd hit in a fist fight with my boss. Then I bdgan to run short each month. Quit selling all my med by 2011 and was fully dependent and buying more each month. Changed to another doc who wrote me 105 30mg ROX and 60 2mg xans but I still run out each month stayed sick wouldn’t work couldn’t work without 90 to 150mg of oxy daily. That doc fired me last July I went to rehab and absolutely loved it. Took about a week to start eating and feeling normal again but I made it till the 41st day. I’m a huge boxing fan and the MAYWEATHER fight was on that night I was mad I couldn’t watch it and just so happen a guy stole my watch. Out my hand thru a plate glass window almost bled to death cut my arm all up. Ambulance driver shot me up with fentanyl and er surgeons gave me morphine etc and I left with a script if tabs. That was back in August it’s been 6 or 7 months I have blown over 45k on Roxie’s and heroin. Been a drought here a friend turned me on to suboxone while I was sick today so I took just half a pill at 4 something and felt great like I had done a Roxie and now here it is almost 12 hrs later and the buzz comes on like I just shot a 30. I’m no longer interested in getting high and just getting by I wanna feel fredkin NORMAL without needing a fix as soon as my eyes open. Wow I think I found what might just save my life and get me off this needle and back to my family and friends and most of all back to work. Sincerely Robert from Mississippi..

4:34 pm April 15th, 2015

Hi Robert. Addiction is more of a thinking problem, and I can see you know it well. You will need long-term professional treatment, counseling sessions, psychotherapy, and/or group therapy to be able to resist the thoughts that compel you to use again. Cravings are the point of any recovery process where the risk of relapse is the highest. But, with a strong motivation and the proper support system, you too can maintain a long-term sobriety.

BOZO
4:27 pm July 7th, 2015

MY VICODIN HAS NO EFFECT AFTER BEING OFF SUBOXONE FOR 2 WEEKS. WHY?

J.c.b
7:54 am July 24th, 2015

I fill for u poor fucks that have to pay 4 ur subs thats wrong.in sunny stevenage they over dose u on the shit.ive been a crack,schag ed 4 15yrs.imust say the w.d.s this time wernt that bad.well come 3rd day over most pains but still in it.subuxone is much ezy to come of. Then subutex.or try and get it in apatch form.even better.but there are times were u on these pillss uchange ur drug dealer for a doctor.not much betwenn them.apart from doctors drugs are bit cleaner.good luck all

Ex addict
6:27 pm August 12th, 2015

Jcb
You need to check into rehab. What you typed made no sense either.

Ex addict
6:29 pm August 12th, 2015

Bozo
You would need to ask a pharmacist.
The subutex got me off herion. I feel great now. Thank God for the subutex.

Jnjn
8:01 pm August 13th, 2015

I have been on 16mg subutex for about three weeks and went down to 4mg today will I feel withdrawal symptoms from this

Mary
10:11 am September 25th, 2015

How long does the dizziness side effect take to stop on initially taking bupenorphin?

wes
6:17 pm October 7th, 2015

Last dose of suboxone I took was about 2mg yesterday at 4pm. Before that I took about 3mg two days prior. My question is, I got ahold of a 30mg oxycodone and don’t know if it would be a waste to take it 24 hours my last administered dose of sub, even tho I rarely take subs. So I don’t think my body would’ve built enough sub tolerance to affect my oxycodone. I need help. How long should I wait to take my oxy?? Any info would be greatly appreciated thanks.

Nikki
4:12 am October 25th, 2015

Hi,
I have been on Subutex 8mg 3x daily for three years for chronic pain and subsequent hydrocodone painkiller addiction (multiple spinal and leg/foot surgeries). Once my specialist detoxed me off of all the hydrocodone (years ago) I have not relapsed back to using/abusing ANY opiates or other controlled substances, nor have I ever had a problem abusing the Subutex. However, for the 1st time ever, I missed my appt., my physician is out of town, & I’ve no refills for my monthly RX of Subutex….this has never happened before & I’m admittedly a little panicked. The last time I took Subutex was today at 8am, the last 1/2 tablet I had (4mg total). I know the half-life of Subutex is 24-72 hours, & I know my dosage is the “ceiling”, right?
When should I expect to go into withdrawal, and can I take regular opiates to stave off the withdrawal until my doctor returns on Tuesday??
I GREATLY appreciate any suggestions or knowledge, thank you!

4:14 pm October 26th, 2015

Hi Nikki. It is most likely that the effects of the Subutex will wear off within 8 to 12 hours. I suggest you go to the pharmacy and consult with the pharmacist about your options and what you can do to prevent withdrawal.

Natalie
8:06 pm October 28th, 2015

Thank you so much Robert for your testimonial! I have recently found myself in a similar yet less abusive situation. Never the less, I too have recently hit rock bottom. My car and meds were stolen I almost lost my daughter and husband. I quit working over a year ago because I no longer had the energy or focus to even care about showing up. My whole life revolved around having pills or finding pills! Just recently my family gave me the option either the meds go or my loved ones go! I went through a week of pure hell detoxing before I found some subzail which is a new better tasting version of suboxin . That was 3 weeks ago and I am now starting to find my self thinking more clearly and slowly but surely getting back to my old self again .
I just wanted to thank you for your honesty because your story has given me the strength and motivation to keep going!

Susan
2:21 am November 2nd, 2015

My friend wants to kick heroin…..he has subutex tablets (4) to help him get through it. How long does the 1st pill last after he takes it? What can I do to help him get through the withdrawls? Will this really help?

5:11 pm November 3rd, 2015

Hi Susan. When your friend will start taking suboxone and the dosage s/he will take should be determined by a doctor. I realize that the medication hasn’t been prescribed by a doctor, but s/he should at least consult with a pharmacist about this.

Suzanne
9:54 pm December 1st, 2015

Taking this drug for heroin addition how long will you be on it for. Like methadone or is there light at the end of the tunnel being drug free all together

1:58 pm December 2nd, 2015

Hi Suzanne. Medical professionals haven’t set a strict time period on the duration of buprenorphine treatment for addiction. It’s usually prescribed for as long as people need it to be able to actively dedicate themselves to therapy, learning, improving…

Angela
3:43 am December 7th, 2015

I am a hydro addict. Took them 10 years, as many as I could get my hands on, sometimes 20- 10 mg’s a day. No medical reason to take them, one day I took one and it progressed from their. This little yellow demon has took my life and everything in it away! I decided I had to do something. 4 months ago went to the clinic. Doc put me on 6mg’s of buprenorphine. It worked for 2 days, the next day it lasted about 3 hours and the rest of the day I was in withdrawal. Doc increased my dose to 8 mg’s.same thing, lasted about 3 hours and withdrawal set in for the rest of the day. This same process was done until I was taking 24 mgs of bupe. When I was taking that high amount it literally made me throw up profusely. And the withdraws were still present the rest of the day. I decreased my dose to 12 mgs and again it last 3 hours and withdrawal the rest of the day. I have never been stable on this buprenorphine. my goal is to completely stop taking any meds at all. I need advice as to what I need to do about this. And have you ever heard of a situation like mine before. I really want to go to work and be a normal productive person in society. I HAVE HAD ENOUGH OF LIVING JUST FOR THE PILL. And that is all my life was. Nothing in this world mattered to me but the little yellow demon.Any help, you or anyone can give me will be greatly APPRECIATED!

Squiffy
2:10 am December 17th, 2015

I’ve been on subutex for about 2 months now. Taking about 2 mg a day through my nose. I’m done with that crap. I got some OP 40s I wanna take. It’s been 48 hours since I last did 2mg of a sub. I’m 150 lbs and have a fast metabolism. How long do I need to wait to successfully feel these oxys ?

Cheryl
11:06 am December 29th, 2015

Natalie what is this subzail that you are referring to I tried looking it up and couldn’t find anything,

Benjamin
1:04 am January 18th, 2016

Does buprenorphine stay in your system for the same length of time, whether you take an 1/8 of a 8 mg pill or say, 1-2 8 mg pills?…im saying if you’ve taken it once, will it stay in your system longer depending on the amount you take?…any legitimate answer would be greatly appreciated, thank you…

PC4
7:50 am March 1st, 2016

If I can help I did it. I don’t want to sound weird but the first thing you have to do is trust yourself. This has been interesting that’s the way I look at it. I can tell you little problems but me after 62 days after taking 8mgs of suboxone a day for the past 8 yrs. before the sub I was taking full scripts aday of Vic percs done you name it. Now I look and smile and say I beat the deavil that is what I called it. Gaba 750 2 a day or some nuratin it’s better then benzos witch I stopped at same time no joke it was interesting but over now. Stay away from salt I had only family no dr. Now believe it your body can get used to melatonin it works great. First Time someone said that I laughed coming off of 8mg of benzos a day lots or k pin and Xanax now it’s nolthing I got it now it is no where above me. If anyone wants to talk more I’m here I’m still reviving but il tell you it’s a lot easier then a lot of ppl say. TAKE CARE keep up good work and never look back it’s the past

kyle
7:21 pm March 1st, 2016

Hi iv been taking 10mg methadone 1-2 a day for almost 6 years and also a few times a week id take a 30mg oxycodone for the same time period,im trying to get off but im scared my back will turn to throbbing fire,so my question is will

kyle
7:29 pm March 1st, 2016

Hi iv been taking 10mg methadone 1-2 times a day for 6yrs and once to a few times a week id also take a 30mg oxycodone,im trying to get off it but im scared my back will turn to throbbing fire!so my question is will Buprenorphine Hydrochloride (Sublingual)8 mg tablets help?i took half of one under the toung just a while ago,also im 23 and weight only 115lbs,please help!(also i was in a bad car accident a few months ago and i have 3 herriated disks and..well a shit ton wrong im just now able to walk without help)didnt know if it would play a factor on how good it would work.please get baxk to me asap

sarah
5:00 pm March 18th, 2016

1st day on subs yesterday. Took 4 mg at 3pm, felt great. Took 2 mg at 8:30pm felt good but got a headache and nausea shortly after. Woke up this morning felt really messed up like I was high. It’s now 11am the next day.. Should I take a small dose? Or let our get out of my system and try again tonight?

2:54 pm March 23rd, 2016

Hi Sarah. Call your pharmacist or check in with your doctor to be safe and sure you are taking the medication in dose and frequency that is fit for you.

Lolita4111
2:58 am April 5th, 2016

I dose my son.. one in morning one in evening… one at night. I need to know if this is WRONG. And tell me pls.. how to do it RIGHT. Bc he is getting yellow around his eyes. Also…. is the subutex 8 mgs. 3 times a day to be taken 3 separate times?… all at once….???…. split dose. Please help!!!!

Lydia @ Addiction Blog
3:41 pm April 7th, 2016

Hi Lolita4111. I suggest you speak with a doctor before making any changes in the dosage.

bessie
6:29 am April 18th, 2016

Does this supulex heal u completely….like u won’t b taking any drug after using it? And once you stop taking supulex won’t u start the cravings of drugs?…….my brother takes heroin and I need to help him out….plz assist

Leave a Reply

Trusted Helpline
Help Available 24/7
1-888-882-1456
PRIVACY
GUARANTEED