Does OxyContin have Tylenol, acetaminophen or aspirin in it?

No, OxyContin is made of oxycodone without formulation combinations. Learn which other brands combine oxycodone with acetaminophen or aspirin here.

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If you have been prescribed OxyContin, you want to be sure that medication does not interact with other medications. So you want to know what’s in it. That’s normal.

But you should be warned that repeated doses of OxyContin over a period of as little as a week can lead to physical dependence. In fact, this risk of dependence is moderate to high, so talk with you prescribing doctor about the risk and be sure to take OxyContin only as prescribed. Physical dependence on Oxycontin does require a period of withdrawal in order for the drug to leave your system. More on symptoms of OxyContin withdrawal here.  But what is in OxyContin? And can the drug interact with other prescription pills?

OxyContin active ingredients

OxyContin contains oxycodone hydrochloride in all strengths as its main active ingredient. Currently OxyContin contains oxycodone as a single ingredient product and is NOT compounded with other products such as Tylenol (acetaminophen/paracetamol), aspirin or ibuprofen. However, other brands do contain such combinations. These include:

Oxycodone + acetaminophen

  • Endocet
  • Lynox
  • Magnacet
  • Narvox
  • Percocet
  • Perloxx
  • Primlev
  • Roxicet
  • Taxadone
  • Tylox
  • Xolox

Oxycodone + aspirin

  • Endodan
  • Percodan
  • Roxiprin

Oxycodone + ibuprofen

  • Combunox

OxyContin alsoe contain the following inactive ingredients: ammonio methacrylate copolymer, butylated hydroxytoluene (BHT), hypromellose, lactose, magnesium stearate, polyethylene glycol 400, polyethylene oxide,, povidone, sodium hydroxide, sorbic acid, stearyl alcohol, talc, titanium dioxide, and triacetin.

Generic forms of OxyContin

You don’t need to buy a brand name drug if you are prescribed doses of oxycodone for pain relief. This is true of OxyContin other formulations. In fact, if you are looking for oxycodone mixed with aspirin, ibuprofen or acetaminophen these types of medications are also available as generics. Ask your pharmacist for more information.

OxyContin and oxycodone are habit forming

OxyContin is generally prescribed for chronic and moderate to severe pain. But it is also a strong opioid pain medicine that can be misused and taken for non medical reasons. You should only swallow OxyContin tablets to allow for the time release to work. If you cut, break, chew, crush, or dissolve OxyContin before swallowing, this is a sign that you are seeking the euphoric effect of OxyContin, and may develop mental dependence on the drug.

How to know if you have a problem with OxyContin? Review the symptoms of pain medication addiction so that you can evaluate your addiction potential now.

Reference sources: American Society of Health System Pharmacists topic on oxycodone
Purdue Pharma manufacturers info on OxyContin (oxycodone HCI controlled-release) Tablets CII
FDA drug safety sheet on OxyContin
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. I suffer from a bulging herniated disc. it wakes me up throbbing every morning. I also suffer from sciatica which is painful as well. My Dr prescribed tramadol ( ultram.) its just not strong enough. I’m.also doing physical therapy. how can I convince my Dr I need something stronger? she’s a real weird about narcotics yet I know she gives a 30 year old man 120.of percocet a month cos he was in a car accident n early Nov. his head was cut open from ear to ear.this ultram is not working well for me. on a scale of 10 being most painful, I’m About a 7 or 8. any advice is appreciated.

  2. Hi Paula. It’s best to direct this question to your doctor. It’s hard to give any advise without knowing your full medical history and current, general health state. So, please, see a doctor for further advise.

  3. I need advice about switching my pain medication! I am taking Narco for severe back pain that repuires surgery and that is not a option. I have Hep. C and have been told that Acetaminophen is the worst thing I can take it affects the liver. Would it be better for me. To take Oxicontin rather than Narco?

  4. One problem with doctors prescribing drugs like OxyContin is that if they have never experienced an addiction they just suppose it’s not too tough to deal with. Non addicts don’t understand addiction. So you need to be very aware of yourself. We have proven with brain scans that if you have one addiction to anything you are at a way higher risk to take on another, and OxyContin is known to be one of the most addictive drugs out there. That’s why it didn’t get the FDA approval the first time it was on the table.

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