How does trazodone work?

Trazodone works by altering the chemical balance of serotonin in the brain. More on trazodone’s uses, side effects, and dangers here.

3
minute read

Trazodone is an antidepressant medication used to treat mood disorders. But how does trazodone affect the body and brain? Can you get high on trazodone? (no)  Does trazodone have the same effects for everyone? What are the dangers and side effects of trazodone use? We’ll explore all those questions and more in this article. And we invite your questions about trazodone at the end.

How does trazodone affect the brain and nervous system?

Trazodone works by increasing the amount of the chemical serotonin in the brain, which helps manage the symptoms of depression. Trazodone can also be used to treat schizophrenia, insomnia, and anxiety. Can you be addicted to antidepressants?  No. Trazodone does not induce euphoria, or an extreme sense of well being that get people addicted. Plus, it’s difficult to abuse trazodone because of its sedative effects – rather than causing a high, trazodone causes most people to simply fall asleep.

How does trazodone work in the body?

Trazodone is a central nervous system depressant which can have some of the following effects:

  • changes in appetite or weight
  • confusion
  • difficulty concentrating and remembering
  • headache or heaviness in head
  • nausea/vomiting/stomach pain
  • nightmares
  • weakness or tiredness

You’re less likely to suffer serious adverse effects if you take trazodone as directed by a doctor. Abusing a drug and taking it in higher amounts than prescribed can often lead to adverse effects.

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How fast does trazodone work?

How fast trazodone works really depends on what you’re taking it for. If you’re using trazodone as a sleep aid, it takes 1-3 hours to work. However, if you’re using trazodone to treat depression, you need to take it every day for anywhere from 1-3 weeks before you’ll start experiencing noticeable effects.

How long does trazodone work?

If you’re taking trazodone for depression, trazodone will stay in your system long enough to continuously help balance your mood throughout the day. Typically, antidepressants are only taken once a day. If you’re taking trazodone for insomnia, the dose will be just enough to help you get a solid night’s sleep (6-8 hours), but it should wear off by morning to allow you to be alert.

What makes trazodone work better?

Different brands and formulas of trazodone need to be taken differently to have the best effect. Some kinds of trazodone need to be taken with food, while others should be taken on an empy stomach. The bottom line is that you need to take trazodone exactly as your doctor has prescribed – and take it before going to bed, since it causes so much drowsiness you may have difficulty functioning if you take it during the day.

Does trazodone work for everyone?

No, trazodone isn’t right for everyone. Some people respond better to different antidepressants than others, and there’s always the possibility of a trazodone allergy or another severe adverse reaction to the medication. Further, trazodone is a good option for people with a history of addiction – while it’s possible to abuse any medication, trazodone is not considered habit-forming or addictive.

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Having troubles quitting or staying off trazodone? Detox is far safer and more successful if done under the medical supervision of doctors and nurses that look after you 24/7. Learn more about the detox and withdrawal treatment of antidepressants to be better prepared for what you can expect when you finally decide to quit trazodone for good.

How trazodone works questions

Please leave us your questions about how trazodone works below. We try our best to respond to all legitimate queries with a personal and prompt response.

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Reference Sources: ToxNet: Trazodone
PubMed Health: Trazodone
DailyMed: Trazodone 
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.

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  1. That’s a good overview of effects. I have use it for years, as it helps me to stay asleep due to spine degeneration. it literally takes 20 to 30 minutes to affect me and make me sleepy and I’ve been taking it for years. It’s the only thing that doesn’t have any significant side effects or doesn’t cause some kind of euphoria which I don’t like. In addition, I continue to take the same dosage and have for many years and it still helps me. That’s pretty rare. Good job on this right up

  2. My doctor gave me Trazodone 50 mg tablets because i have been having trouble with my bowels. haven’t slept last night should I take one pill know it’s 5;30 I do not want it to afect my sleep for tonight

  3. If I take trazodone just before going in the sauna does it reduce its effectiveness
    in going to sleep two hours later. Or is it more effective to take it after my 30 minute sauna. THANKS FOR YOUR ANSWER AND ANY OTHER COMMENTS ABOUT THIS QUESTION. I ALSO AM FiNDING THAT I AM still sleepy up until 10 am after getting up at 6am. Ideas?
    Thanks,

  4. I am experiencing nightmares when I take trazodone at bed time, will they eventually stop the longer I take them?

  5. Dee & Jude, You 3 Adderall prescriptions with them being a schedule 2 drug are recorded by federal law. At 75mg daily you are still under maximum level but you are close. It’s been awhile since I checked. There is a maximum mg that triggers the feds, be careful.
    Adderall 20mg 2X’s a day are less than $25.00 at most discount big box large chain pharmacy’s. Other pharmacy’s even large chain ones were $75.00. Check around prices really vary.
    I do feel for all that struggle with mental health.

  6. I have been on 1mg. Of clonazepam and 6 mg. Of silenor for all my life, I am 73. The drugs don’t work anyone and I refuse to increase. I have tried to get off of them, but no avail. I have had insomnia all my life. The doctor gave me 150mg. Of trazodone, I cut down to .75 of the clonazepam. I have had the worst two nights sleep of my life! I have been taking all the drugs together about 45 minutes before coming to bed. I just read that I should take the trazodone maybe 3 hours before going to bed. Could that be the problem? I am ready to quit the trazodone!

  7. Hi,

    I have been taking 200mg of Trazodone for Anxiety for around 10 weeks (100mg for the first 8 weeks) but having trouble with sleep. I fall asleep fine but wake up in the middle of the night after 4 – 5 hours sleep and then cannot fall back to sleep. I have been struggling with this for 8 weeks or so and the lack of sleep is fuelling my anxiety. Anyone else suffered in this way? Will it pass?

    Thanks

  8. Dr gave me trazadone for sleep it does make Jeep me asleep for only 4 hrs but I am groggy the next day. I help my tingly feet, cold, head pressure is not worth it. Plus it’s not a perminate solution.
    I used to use benydyl for years then it stopped working. I could have increased the pills but I didn’t want to.
    I got 6-7 hours of sleep on benydrl but trazadone only 4 . Not enough.
    Any ideas

  9. Hi I’m steven I had been taking trazadone for over a month an was just fine but for the past 3 weeks I have been in and out of the hospital with migraine headaches that last 4-9 hours at a time everyday. The doctor said it was possibly the trazadone since then I have stopped taking them an symptoms are slowly going away less migraines if any at all I do not suggest anyone take this but that I just my opinion

  10. I was given Trazodone in January 2017 I was told that I was taking a sleeping pills, it did not help me sleep and was made to continue to take it with all the side effects and increased the dose to 150 mg. Was weaned off by April 2017 and today is October 2017 and I am still having side effects… I have suffered long enough.
    Am I the only person who has had a severe allergic reaction to Trazodone and the withdrawal side effects?
    I would like to meet at least one person who has this same experience.

  11. I suffer from severe restless leg syndrom partially relieved by medication .for sleep i take half a stillnox and 2.5 mg clonex
    I am concerned about the danger of addiction
    Tried for a few months an antidepressant withno positive effect.could trazodone work for me as a sleeping help

  12. Hi. I have insomnia and restless legs. I just started Trazadone 50mg. Hasn’t been working. I have taken it and then just gone to bed and tried taking it 1 hour before bed. Also , an hour before bed I stop watching tv and using my iPhone I am just so tired. Please, can you help me? Thank you

  13. My daughter in law just passed away. She had an arrhythmia in her sleep after taking phentermine (37.5) and Trazadone (150). Could this combination cause sudden death?

    1. Hi Donna. I’m very sorry for your loss. Before using two medications at the same time always check how they influence each other. You can also consult your doctor about any negative effects or other concerns you might have. You can use this drug interaction tool: http://www.umm.edu/health/medical/drug-interaction-tool to find out the safety of using multiple prescription drugs at the same time.

  14. I’m getting no relief for my insomnia from ambian

    I’m switching to 50mg trazadone

    Is that a good idea

    I’m a 78 year old man

  15. My doctor prescribed 200mg of Trazodone for sleeping. (He had prescribed 100mg before, but it did nothing for me). I hate it. It does help me sleep, but in the morning I can barely function. I lose my balance, feel dizzy, can’t drive, do things like put a dryer sheet in the washer, and feel like I’m in a fog. I rather not sleep than feel like this. I function better with 3 hours of sleeping than taking Trazodone for 8 hours of sleeping.

  16. I have moderate to severe depression and have been taking Escitalopram 20mg for 3 months with Trazodone added over last 2 months to “boost” it’s effects (initially at 50mg now up to 200mg)
    Apart from getting a very good nights sleep I’m still feeling both anxious and depressed – the psychiatrist still seems convinced the meds will work although I am sceptical. I realise that the dose could be pushed up to 400mg ( I see inpatients can be given 600mg!)
    Wondered if anyone had any comments on my experience ? Thanks.
    John

  17. Is it safe to take Trazadone because of the side effects too? I take it for insomnia but my Dr says its good for depression.

  18. Jenvy: you’re describing classic symptoms of hypothyroidism. Hair loss & depression r classic symptoms. Who knows, maybe the trazodone affected an already undiagnosed thyroid condition or it could have just gotten spontaneously worse. And if you’ve been tested for thyroid problems & test results landed in the “normal” range, that doesn’t mean you don’t have hypothyroidism. There really is no normal like a 98.6 temperature. They r supposed to take into account your symptoms. See Mary Shomon’s website for a much more detailed explanation in laymen’s terms. Goo luck!

  19. I’ve been on 150mg of trazodone for about 5 years (and lots of other antidepressants for over 20 years) & any physician or psych who says “witdrawls are minimal” is full of it. It varies from person to person & drug to drug, & psychs mostly depend on reports from pharmaceutical companies, who r, of course, always completely unbiased & completely unmotivated by money. (Synocism intended) Try “nutritional psychiatry.” There’s overwhelming & mounting evidence that mood & behavior can be & is affected by nutrition or lack thereof. And if using nutrition as medicine may mitigate or even cure tortuous mental illness, it’s innocuous & so worth a shot. Traditional psychiatry where they only hand you multitudes of pills is now archaic, medieval & has detrimental long term effects & can create serious chronic, lethal conditions & diseases. They don’t tell you that. Find yourself an excellent integrated physician & nutritionist, & change the way u eat. I did that, & I’m telling u, after 20-25 years of standard psychiatric drug “treatment” that did nothing but make me worse, I feel the best I have in 25 years. Do some heavy, serious research on recent nutrition & mental illness on real clinic trials, & you’ll see I speak truth. Please please look into nutritional therapy at least as an adjunct to medication. Don’t suffer 25 years without hope for ever getting better, without hope of ever getting off drugs & being normal & your old self again. Try it. What have u got to lose?

  20. My SOP was prescribed Ambien (7) to help him sleep after being diagnosed with Ringing of the ears. We are going to Mexico this Sunday & asked his Drs. for more ambien. They would not give it to him. They gave him 30 trazodone which isnt working. He started taking Lipo Flavonoid but it will take time to kick in to help the ringing of the ears. This ringing is driving him crazy. Its in 1 ear only. Is there anything to drowned out the ringing. The ambien was the only thing that helped. He is 70 and has always had a problem sleeping. We will have a terrible vacation if he doesnt get sleep. Thanks….any suggestions

  21. My wife has Alzheimer’s and I’m her carer. What is the latest about benefits of trazodone for Alzheimer’s sufferers. My thanks.

    1. Hi John. Trazodone (Desyrel®) is an antidepressant medication that can treat low mood and irritability, and also tends to make people sleepy. The drug has a calming and sedative effect.

      On another note, trazodone can lead to a prolonged sedation in the elderly, so if she starts taking it, she will need regular check ups to make sure she eats and drinks as she should. Increased sedation can lead to dehydration and malnutrition.

  22. Hi Ann. It would probably be best to seek the advice of a licensed pharmacist. They often go under used and can be consulted on questions just like this.

  23. Good afternoon
    My mom was diagnosed with dementia but is has always suffered with bipolar. She is not on a
    therapeutic level on lithium but the Dr. prescribed 100 mg of trazadone. 50mg during the day
    and 50 mg at night. I find her to be manic with this medication.
    Can you tell me alittle about this medication.

    thank you
    Ann

  24. how does the trazodone work inside your body,for instance does it break down in your stomach? How does it get to your brain?

  25. Can taking Trazodone help you to come off or down from Molly (MD-MA)? Say you took some Molly and been focusing the shit out of everything all day and your just tired and want to sleep or you just realized that you have work in the morning so you need to get to sleep asap? Will taking a 50 mg Trazodone while on Molly be bad or good or OK? Need to know asap Please

  26. Ive been taking trazodone for 10 year’s.My doctor has increased the dosage of time. I find trazodone an absolute amazing sleep aid.I beg to differ with the above article,as trazodone has me out like a light within 30 minutes,it doesn’t take 1 to 2 hours.I have Bipolar 1 disorder and ive been on more meds in 10 year’s than most will be on in a life time.At current i ONLY take trazodone and homeopathic remedies.

  27. I’ve learned that if you take smaller amounts it works better. I was prescribed 50mg and started taking it and felt reallllyyy groggy when I woke up. So I started taking less and less till I got to the amount that allowed me to sleep thru the night but not make me groggy when I got up. So I take half of a half. Some people need a whole half some people need less than half of a half. Try taking a tiny amount less until you find what amount works for you. I’ve also read that trazadone is a serotonin balancer.

  28. I discontinued trazodone after having violence filled nightmares for 4 nights in a row. I did not sleep well either. I had confusion and seemed to be out of touch with reality. I took qetiapine afterwards which helped. Now I’m off that for a while and take tamazapam 15mg. At least I get some sleep and no nightmares.

  29. I have both depression and severe insomnia most meds have failed at putting Me to sleep as My sleep debt and symptoms grow. . I now am suppose to try 50mgs of trazadone but I dont need any help with My epinephrine as I now have a brain in hyperarousal. if anyone has any other suggestions please let Me know.

  30. I am 57 years old and am bipolar.I have taken a ton of different meds since I was diagnosed about 25 years ago. I started when the older and much more debilitating medicines which were all that were available then.Since then I’ve move ahead as new medicines were developed. But trazodone ,after being off it for a few years because of the hangover affect, I decided to try them again for sleep problems. I stuck with them and after a few months the hangover was gone. I have a very medicine generous Dr. and am taking 600mgs. at night. I also am thinking that they are not working any more and am at the point of quitting. After all there are so many good medicines out there why not..

  31. Thanks for the info. I was prescribed trazodone a week ago as a sleep aid and could not get to sleep for a long time. Last night for 3 hrs. Your article is helpful and I will take the drug 2 hrs. before going to bed. Can I take 500mg. gaba with trazodone? The doctor prescribed 50mg. of trazodone to start. Maybe I can increase it to 75 MG. ? Thanks again.

  32. If Trazodone for insomnia is only taken as needed, or is skipped occasionally, can this lead to withdrawal symptoms? Labeling says do not stop without consulting your doctor. Thanks.

  33. I have been taking Trazodone (100mg nocte) and Cymbalta (60mg morning) since early 2013 when my wife passed away. I am 78 and over the last 6 months my short term memory has gone to pot! I have also been very tense for a long time, it being necessary to force a relaxed mood and use a Yoga meditation chant to become calm and stop twitching.
    Could my condition be related to these two drugs? I also use 10mg Zopimed at night.
    Thanks for an interesting site.
    Kind Regards
    Terry

  34. I’m taking 50mg and its meant to be helping with my sleep and depression, my meds get blister packed at the pharmacy, its in the night slot, any idea when the best time would b to take it to help with both. Thanks tracy

  35. My questions is why after taking Trazodone 200 mg at bedtime do i have insomnia most of the night. I have been on this medication for 15 years….very frustrated! This has been going on for months Thank you!

  36. Sam,

    Of course, everyone is different. I finished titrating off of Trazodone, as described above, about 2 months ago. Sleep was a challenge every time my dose went down, for about 3 days. I have just recently started to feel like I’m sleeping well on my own in the last week or so (I use a sleep app to monitor my sleep quality). I am sooooo grateful for that! I advise taking your time to allow you brain chemicals to catch up, and being patient with yourself. You can take your tablets to a compounding pharmacy to pulverize and accurately measure out your smaller dose, if that makes it easier.

  37. How long will side effects last when starting out with 50mg. Does your mind adjust after a couple of weeks like other ad’s

  38. I am 47 years old and 3.5 year along after a 1600mg/ day ( 7 years) prescribed OxyContin detox. Sleep was the biggest issue after the nasty part of withdrawal. I am currently taking 100mg of trazadone and 300mg Wellbutrin XL per day to increase serotonin levels and it has help the urges to get high (however you choose to do that). I have noticed if I stop the trazadone for any length of time I spiral down fast. I want to get high all the time and enter a deppesive state, poor sleep and anxiety (which I have never suffered from until I detoxed). When I start back with the trazadone I recover quickly ( 1 week) back to my normal state of mind. This combination of trazadone and Wellbutrin has allow me to stay sober while my brain continues to slowly recover.

  39. Thank you very much for your specific answer to my question in July 2015. That really helped. I have since titrated off by 5 mg increments every two weeks (My dose was at 50mg each night). My last dose was a couple of weeks ago. I am still feeling a bit foggy-headed and don’t know if that’s just because my brain is still adapting to not having the Trazodone in my system, or something else. Is there something natural that I can take that will help my brain adjust, or do I just need to wait? How long is the adjustment period normally? I was taking Trazodone for 20 years — I, of course, was never told of the potential damage that could do to my brain. Thank you for your expertise.

  40. Im not sure but i had avisit with my doctor today. Im taking 100mg of seraquel and 25mg of tranzodone, she believes im taking to much of those meds.Thats my psychiatrist who prescribe those meds. she believes to much seraquel,lets make along storyshort,I havent had any trouble taking tranzodone PRN. Always remember Gods in charge. Happy Holidays God bless will keep all us in prayer.

  41. Could I take this on an as needed basis. I become very anxious with work and find my insomnia is greater during the week. On weekends, however, I have no problems. Could I not take the trazodone during that time and still get the desired effect when I need it during the week.

  42. To make a very long story short…On June 8th I was prescribed trazodone for anxiety and occasional High BP. Dr. told me to take 50mg nightly. I started off quartering it and then slowly increased to only 25mg. I’m guessing over the course of 3.5 weeks I took 25mg. I’m thankful I only took that much! I regret taking it after the 1st night! My gut instinct told me to toss all of them down the toilet since the next morning I woke with what felt like, a severe hangover. I also have a 2.5 year old so understandably I was scared to take it at all! My Dr. told me to increase to 50mg or I wouldn’t see results. Almost a month later I noticed my hair shedding like crazy, and my healthy head of hair looked all knotted and dry. I finally put 2 and 2 together and realized I was suffering from hair loss induced by the trazodone! I frantically called my Dr. who I saw that day and he told me he didn’t think it was due to the trazodone. (What?!) and referred me to a dermatologist who told me the same thing! He then told me to google telogen effluvium, and to buy 5% rogaine and that my hair loss would, “taper off eventually.” Thanks for nothing Doctor! Needless to say, once I found out my trigger for my hair loss I flushed that poison known as trazodone down the toilet! (On July 8th). Since then I’ve estimated about 35% hair loss. Since stopping the trazodone, it appears that the hair loss is not 200+ as it once was. But I am still loosing 100-150 a day! I’ve read that it can take several months, and up to 6 months for the hair loss to subside and regrowth to occur. I have no idea, day to day if the hair loss will lighten up…when it will stop….if my hair will grow back? I’ve spent countless hours crying, and depressed trying to find anyone who’s gone through this like I have. The only positive I can try to gather from having gone through this is that I will NEVER take another mood stabilizing drug again! This is poison you’re putting into your body. I’m beyond disgusted that a physician can sit down with a patient for 10-15 minutes and write up a prescription for a mood stabilizer when a more natural approach could have been taken! Please research in depth any medication you’re prescribed. I wish I had done this! Everyday I regret not taking the time to do this, and I placed my life in the hands of this so called expert.

  43. I need to know EXACTLY how Trazodone works, please. The description in the article is very generic. Please describe EXACTLY how the Trazodone increases Serotonin. Does it block the reuptake, like an SSRI? Does it cause the body to produce more serotonin? Does it increase the serotonin receptors? Please be more specific. Thank you.

    1. Hi Mcooks. That’s a very good question. Trazodone prevents serotonin from being reabsorbed back into the nerve cells in the brain. It also has the ability to mimic the mood-enhancing effect of serotonin and slightly enhance the release of noradrenaline from thee nerve cells in the brain. I hope this answers your question.

  44. I take it when I’m about to go to sleep. But sometimes I don’t fall a sleep for an hour or two after I’m in bed and I still sleep right thru the night.

  45. Hi Danny,
    I tend to take Trazodone at 10pm every night. I head off to bed at about 10.45 and usually within 30 minutes I’m asleep. I also take Mirtrazapine 15mgs at the same time. Recently I’ve not had that woozy feeling of falling asleep and have had some broken sleep so I’m wondering if my body has got too used to these meds. I’ve been on Trazodone for a year and added in Mirtrazapine in November 2014 as even 200mgs of Trazodone was not helping me sleep.So my advice would be to take them at a set time every night an hour before you go to bed. Apparently Trazodone works best if taken with food or at least a glass of milk to help it absorb into the bloodstream quickly. Good luck. G

  46. Hi Danny,
    I tend to take Trazodone at 10pm every night. I head off to bed at about 10.45 and usually within 30 minutes I’m asleep. I also take Mirtrazapine 15mgs at the same time. Recently I’ve not had that woozy feeling of falling asleep and have had some broken sleep so I’m wondering if my body has got too used to these meds. I’ve been on Trazodone for a year and added in Mirtrazapine in November 2014 as even 200mgs of Trazodone was not helping me sleep.So my advice would be to take them at a set time every night an hour before you go to bed. Apparently Trazodone works best if taken with food or at least a glass of milk to help it absorb into the bloodstream quickly. Good luck. G

  47. Does trazedone for insomnia have a “window”? I’ve heard that you have to take when you actually get into bed. If you’re not in bed then you miss you’re “window”? But then again, some say it could take 1-3 hrs. How do you actually take it?

  48. I have been sober for 3 yrs now. I’ve had serious sleep issues ever since. I work nights(bartending). Been on sleep medication for 4 months now. Temazepam at first. Now Trazedone for 17 days now. My recent doctor visit he told me 3mg melatonin 2hrs before bed and then 100mg Trazedone at bedtime. Sometimes it works and sometimes it doesn’t. When I get home really late it doesn’t work at all. I stayed up all night Fri and Sat. It’s like a love hate relationship. Maybe I should start taking Trazedone 2 hrs before instead of 10 minutes before. Any advice or input would be appreciated. Also, I always wondered something. Does my past addiction to alcohol have anything to do with my problems with these medications? Every night when I go to bed I get real nervous and scared b/c I don’t know if this will be a night where I sleep or stay up all night? Thanks

  49. I suffered from severe insomnia after I went into menopause. I also have restless leg syndrome. Trazodone helps both. I don’t know how, but I’m thankful it does. I’ve been on 100 mg trazodone for almost 20 years with no side effects.

  50. Hi, I’ve suffer from Fibromyalgia with depression & widespread aches & pains for years. The pain is worse if I don’t sleep well. My GP (who has just retired but knew me best in the practice) had me on Trazodone 100mgs for 7 months which really helped my depression but not my sleep so I ended up in a lot of pain. He then advised me to take 200mgs(which I did for about 2 months) but my sleep did not improve so I returned to the 100mgs. Eventually my sleep got so bad that I did my own research and asked him to put me on Mirtazapine 15mgs. That worked really well so I’ve been on both for 4 months now and feel great. My question is will I have to stay on these drugs forever? The Mirtazapine has made me gain over a stone in weight whilst the Trazodone on its own made me lose my appetite and therefore some weight. I’d like to lose weight but continue to feel and sleep as well as I am now but I fear I may need to be on something to keep me in balance. I was on Amitriptyline for years but gained 2 stone and came off it due to side effects. Any ideas.

  51. I was prescribed trazodone after anxiety attack and sleep disorder.Does trazodone help in restoring the sleep pattern back

  52. Hi Bridgett. Trazodone is not primarily prescribed for ADD. They say it helps sleep, although many users disagree, and doctors also prescribe it for depression. It also slightly raises serotonin levels and that can affect ADD, but it’s not a medicine that would greatly help or treat the condition.

  53. Hi Lindsay. I’m not aware of such interaction between Thrazodone and Methadone. But, you still need to be carefull. If taken in sufficient quantity, these two medications can cause central nervous system depression and slowed breathing.

  54. I am on methadone for opiate addiction. I am also on trazadone for sleep. Will trazadone cause my methadone to not work properly ?

  55. wow. very interesting. im on 100mg at night. hoping It Will work for me as im already on prozac, diazipam. i Was also on Atarax that for some reason i Had an awful reaction to. good luck To All and i Wish u All the best.

  56. I’ve been taking this for a while now and it works great for sleep. The trick is to not take a whole pill or while half if you find you feel fogged when you wake up. I take a little over a half of a half of a 25mg pill and I sleep right thru the night and don’t wake up feeling funky. In the beginning I didn’t know any better and was taking a whole half or whole pill and woke up very groggy!!! But once I figured out the amount I need I’m totally fine. Every one is different. Some people might need a whole half some a half and a half of half some people maybe a crumb. I Don’t know about taking it for depression though just sleep. I’m not a doctor I only learned from taking it myself. Consult your doctor about it.

  57. Hello Laurie. This is a question for a medical professional such as your prescribing doctor or a pharmacist. Best of luck to you!

  58. can I take things like melotonin or gaba with Trazadone to help with the effects since it is not working quiet well enough by itself? Thank you for your response.

  59. Dave, maybe your suffering PAWS. I have been struggling with it for the past year and the anxiety has been the worst. I personally believe you can get it from quitting anti-depressants and other drugs (not just alcohol). I have gotten a fair amount better in the past year and a bit but the first 8 months were pretty awful. Hope your feeling better soon.

  60. Hi Dave. It sounds like you might benefit from the expertise of a trained and licensed psychologist or psychiatrist. Generalize anxiety and depression can be the result of low energy, but there can also be a mix of pharmaceutical influence that’s not working for you. You’ll need an expert medical opinion to move forward.

  61. I take 150 dose for sleep nitely. It helps me sleep but have had alot of anxiety and depression during the day any suggestion

  62. Hi Jenny. Check in and speak with your prescribing doctor about your concerns. Or, you can talk with a pharmacist about the way that trazodone affects the central nervous system. You’ll need expert counsel and advice on these questions.

  63. Hi, I have been suffering post acute withdrawl for 9 months now and although my anxiety and difficulty sleeping are impoving, it is very slow. I am wondering if taking trazadone will interfere with my recovery. Will the chemicals in my brain continue to improve even though I am taking trazadone? I am scared to take it as it has been very hard to get to this point now where I can hold a conversation, and also, get some sleep and I do not want to take a step backwards. I am thinking about taking 25 mg per night for sleep. Thanks!

  64. Thank you for a most informative site on depression and insomnia. Since taking Trazodone I hove found that I have become slightly more aggressive and have more courage to say what I feel. I have always been labeled a “doormat” all my life. Has anyone else experienced this effect. Thank you again, Susan

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