How long does tramadol last?

The effects of immediate release tramadol last for 4-6 hours, while extended or controlled release tramadol lasts for 24 hours. Learn more about tramadol dosing, dangers, and more here.

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Immediate release tramadol lasts for 4-6 hours. Extended release tramadol lasts for 24 hours. More here on the duration of action for tramadol, tramadol addictive properties and a place at the bottom for your tramadol questions.

Tramadol effects on the body and brain

Tramadol hydrochloride is an opioid agonist medication used as short term analgesic to manage moderate to severe pain. Although experts aren’t exactly sure of how tramadol works, tramadol has been seen to bind parent and M1 metabolites to µ-opioid receptors in the brain and to cause weak inhibition of reuptake of norepinephrine and serotonin in the brains of mice and rats. In short, experts know that tramadol works by affecting the levels of different chemicals in the brain.

Tramadol is a central nervous system depressant. The most common side effects of tramadol are dizziness, nausea, constipation, and drowsiness. When taken as prescribed by a doctor, tramadol can offer mild pain relief as needed. However, when taken to try to achieve a euphoric high, or used long-term to control pain, tramadol can become addictive.  Tramadol overdose amount generally occurs over the 450 mg tramadol daily safe limit, but mixing alcohol with tramadol can increase risk of serious adverse side effects, including slowed breath and loss of consciousness.

Tramadol duration of action

Tramadol hits its peak blood plasma level an hour and a half after the drug is taken. Tramadol has a half life of 6 hours. The immediate-release tramadol tablet will need to be taken every 4-6 hours for continuous pain relief. The extended-release tramadol tablet, used mainly to manage chronic pain, will last for 24 hours, and is only taken once a day.

Tramadol time in the body

After more than a day or two, it’s unlikely that tramadol will still be present in the blood. Tramadol extended-release version may take a little longer to clear the blood than for the regular variety of the drug, as it’s released continuously throughout the course of the day. furthermore, tramadol will show up on urine screens for 1-2 days, but can stay present in hair samples for 90 days or even longer.

How long do tramadol effects last

The effects of tramadol won’t last long if you’re taking an immediate release tablet – only 6 hours at the most. If you take the controlled release tablet (as directed, without tampering), the effects should last all day, a complete 24 hours. However, if you tamper with the controlled release tablet by crushing, chewing, or snorting it, the effects may be immediately delivered to the body but will not last as long. Not only that, but you’ll be running the risk of overdose from releasing too much tramadol into your system all at once.

How long does a tramadol high last

Although some people do not think it possible, others claim that a tramadol high lasts between 4-6 hours, since that’s how long it takes for the drug to be cleared from the human body. In order to get high on tramadol, you will have to tramadol other than prescribed (snort tramadol, inject tramadol, or smoke tramadol or take higher/more frequent doses of tramadol). However, trying to get high on tramadol is dangerous because of the risk of tramadol overdose and addiction.

Tramadol high effects

Tramadol does not trigger euphoric feeling for everyone who takes the opioid. In fact, getting high on tramadol is an adverse side effect with incidence rates of 0.5% to <1.0%. Although rare, tramadol’s pain-relieving effects can also have the side effect of causing a high. However, tramadol can also be addictive, so abusing tramadol to get high does carry risks. In self-reported examples, people have reported some of these tramadol high effects:

  • cheerful mood
  • estatic mood
  • intense happiness

How long tramadol lasts questions

Do you still have questions about the duration of action for tramadol? Please leave your questions about tramadol below. We are happy to try to answer your tramadol questions personally and promptly. And if we do not have the answer to your question, we will refer you to someone whoe can help.

Reference Sources: PubMed: Tramadol extended-release in the management of chronic pain
PubMed Health: Tramadol
DailyMed: Tramadol Hydrochloride
Toxnet: Tramadol 
About the author
Lee Weber is a published author, medical writer, and woman in long-term recovery from addiction. Her latest book, The Definitive Guide to Addiction Interventions is set to reach university bookstores in early 2019.


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  1. I took a half of a 50 mg tramadol and that was at 11:30 pm now its 6:31 am and i feel anxious feeling.. How long will that last?

    1. Until you take your next dose, your body is becoming dependent on the drug being in your system, do you take any anti depressants? If so, could be serotonin syndrome. I get the same feeling. Vicious cycle.

  2. I have been taking Tramadol, 50mg HCL for about 4 years for relief of pain from Spine Stenosis. I take 3 pills a day, at the same time, about 11:00 a.m. I do not take any more unless the pain becomes severe later in the day and then I only take 2 pills. I am concerned that this might be increasing my dementia. It does seem to becoming stronger as the time passes. I also take steroid injections at least 3 -5 months as allowed.

  3. I’m taking Médical Marijuana (zen-1cbd-4thc) with meals 3 times a day, and
    another 25 mL at middle of night.
    If I need Tramadol for chronic pain,
    How should I space it between every
    25 ml dose of med marijuana?

  4. Will Tramadol 50mg help with reducing the tingling feeling under my armpit?Most of the scabs have come off after having shingles for four weeks?

  5. I was prescribed tramadol for really bad sciatica at the beginning of May, at the peak I was taking 4 x 50mg immediate release every day. i was then moved to 100mg slow release x 2 a day. They weren’t as effective, so I went back to 4 x 50mg.
    I have gradually reduced the dose to 2 x 50 mg immediate release every day. I want to come of them completely but am worried about stopping them suddenly. Is it reasonable to switch to 1 x 12 hour slow release for a week and then stop altogether

  6. I’ve taken 100 mg of tramadol for about 6 months. Can I just stop using it or should I taper off. I’m not sure what happens if I just stop.

    1. Hi Jim. The safer way to quit tramadol is by slowly reducing the daily dose. I suggest that you consult with your doctor to help you plan an individualized tapering schedule.

  7. I’ve taken tramadol everyday for 20 years. The dose I use is 200mg a day. I would like to know when used long term, how long does tramadol remain effective in helping with pain.

  8. I took about 25 pills of 50mg over a 15 hour period. I took my last dose about 4 hours ago. Am I still at risk for overdosing!

  9. I used 50mg Tramadol Hydrochloride capsule last night and have no intention of continuing. How long is this sickly feeling and drowsiness going to last and are there any withdrawal worries to expect

  10. I was given a tramadol shot at the er @ 4:40 am by the time I got home and laid down to go to sleep the pain was coming back strong @ 6:30 am. Why didnt this last? What tyoe of medication should I discuss with the dr about taking? Nothing over the counter works, loratabs nor does this Tramadol. I have Trimeginal Neuralgia. The pain is unbearable. I cant eat, sleep, everything including a slight breeze is killing me. Please help. Im tired of these dr not taking me serious about how painful this is. Please help me.

  11. I’ve been having withdrawal symptoms from weaning off of effexor and mirtazapine for about 1&1/2 years. It’s been 9 months since my last pill. I started taking tramadol two months ago for withdrawal relief. I’m afraid to use it any longer because of major weight loss and other issues. I feel better now than without it, but I have to see if I can do fine on just 100mg immediate release 25 MG four times a day

  12. I use tramadol for a month as pain killers when I had operation on my leg and now i feel some infect on my body how can i treat the infect?

  13. As Tramadol wears off I have a weird head and if I fall asleep I wake up in a panic state is this normal and how long before it stops?I’m having headache anxiety crying. Can’t sleep and if I do I wake up on a panic since I’m on Tramadol how long will this last. I’m 76 and live alone.

  14. I’ve been on 10 mg of methidone and lortab 10/325 for the past 15 years. It was prescribed ny my Neurologist who worked with me for years to establish these dosages. It had excellent pain control with no bad side affects or highs except for occasional constipation.
    She passed away 5 years ago, and my records were sent to a pain management Dr. he consulted with me about my condition and agreed to keep me on the same meds.
    Recently, he told me he wanted to take me off of the methadone and Lortab because of all the attention Methadone was getting about misuse and overdosing. He put me on Percocet. He told me this was stronger than what I had been taking. I noticed right away my pain jumped up 30%.
    I was wondering if Tramadol Tramadol would be a good substitute for the Methadone I had used in the past. I’d also like to know if it would be better to have the time released version of the or the regular tablets that aren’t time released?
    Thank you for your help,

    1. Hi Sheila. The safest way to quit tramadol is by slowly reducing the daily dose over. I suggest that you consult with your doctor to help you plan an individualized tapering schedule.

  15. I was prescribed Tramadol ER it says to take 2 once a day,it’s 100 milligram each.after reading all the side effects, it scared me a little so I just took now I’m wondering if I should’ve taken both, and if so when should I?

  16. I have been taking tramadol for two years now, 200mg daily for body pains but now I want to get out of it and I want to know how long it will take for it to clear off my blood

  17. Sir my mom is long term seven Tramadol injection and near about 2 year continuous take .
    how to relief my mom body pain .And any medicine not work my mom pain. please solve my problems..

  18. I have neen taking 200mg of tramadol a day because i could not get my oxycodone will well it was filled today and ibe1 taki h 100mg of tramadol ready when can i take my oxycodone

  19. Take 7.5mg hydrocodone every 4 hours but my doctor also gave me Tramadol for breakthrough pain is it safe to take them both on a big worry wart and always thinking about what could happen really could use an answer thank you

  20. I’ve just been prescribed Tramadol, one 100mg at night. They don’t touch my pain, I’ve tried taking 2. I’ve taken co-codemol for years, and they don’t work anymore. My doctor will not listen to me. I’ve type2 diabetes and I’m a 63 year old female. I’m really fed up. Is there anything stronger? I’m definitely addicted to painkillers but when you’re in pain you don’t care.

  21. I was wondering how long is tramadol useful in helping relieve pain. I’ve taken it daily for twenty years for chronic pain and was wondering if after such a long time it still helps with pain relief.

  22. I have a ? My husband is given 120 tramadol an hes allowed to take 3 a day how long should that last him? An when should he get it refilled?

  23. My Mom is 87 years old and has been taking 50mg Tramadol and Tylenol daily for tendonitis of the glut. She now has pain management but now has insomnia depression and anxiety. Anyone else have these symptoms while takjng these drugs? I

  24. Took more than my recommended dose of tramadol almost 5 hours ago. Feeling okay but keep throwing up. I have a pretty good tolerance to opiates should I worry?

  25. I have been on tram 50mg 3 X daily / as needed for over 5 years. Given to me after foot surgery, it also lessened my fibromyalgia pain. All other meds given prior to surgery for my fibro did not work. Dr recommended that I continue with tramadol. Although I find relief of pain, the horrible feeling of anxiety, shivers, sweating after 8 hours is not pleasant. Will a pain management doctor with treatment ever get me out of this dependency? I am 79 years old. I am trying to wean myself but not been able to and I know brain cells are being altered. Please respond.

  26. I am prescibed 4x 50mg Tramadol a day for rheumatic pain in hips. I have been taking them about a year and have gained 2 stones in weight. I also find it hard to shift any weight despite hard dieting. My legs-abdomen are swollen and i have pain across the bridge of my right foot. I have memory loss most days too. I’m going to come off them completely and see what the difference is to my health as I’m only in my 30’s. Has anyone else had the weight gain and swelling side effect?

  27. Hello, I have been taking tramadol for about 2 1/2 months, now trying to get off the Tramadol.. but it’s very difficult! I’m also on Lexapro and Seroquel.. am I going through withdrawals?? I’m trying so hard to get off the pain medicine! I basically took the tram a doll for the shingles, then I tried to get off of it, but I couldn’t.. my doctor recently upped my antidepressants as well.. because I found myself not sleeping once again, can someone help me, or give me some good feedback !! Please!! Thank you so much!

  28. Hi. I was introduced to Sr Tramadole 2 years ago and would only take them to get through long hours of work maybe once or twice a week.
    Than a year ago I had a accident and I ofcoarse chose Tramadole for pain relief, which they were fine with because I let them know I don’t like endos or the others that make you drowsy ect.

    I getting pretty worried now (which is horrible as I have bad anxiety), that the good feeling I was getting is not happening anymore even if I try up to 400mg a day.
    I can tolerate the injury pain but just want to have that same happiness I’ve had for the last 2 years. I don’t want to be a depressed anxious mess ever again and the last 2 years have been the most confident and productive of my adult life. Which I know in itself is pathetic.
    I just wish I can keep waking up happy and not sad again, like taking as a med to keep me going right and not just feeling hopeless. The more I think of this the worse I feel.
    Thanks for hearing me out.

  29. I only take 1-50 mg pill at night for my RLS. Can I get addicted if I take it too long. I never take more than 1 a day.

  30. Hi Julie, I was taking Contin MS for 10 years prior to now taking been on Tramadol ER 100mg x 2 daily for 7 years. My Pharmacist has told me that Dr has now prescribed 50mg IR Tramadol to be taken up to 4 times daily as well as the ER 100’s.
    I don’t know why he did this as I didn’t request it, I don’t want it and I am doubtful as to whether it is a good idea to increase the dose. What do you think? Did he do it for a reason or in error??

  31. I don’t want to take tramadol for my stomach and back pain. I’ve been advised by my current gasto spec nurse to take it and that the doctor won’t prescribe narcotics. I don’t want to be on a narcotic. I just want something comparable for pain. I’ve been in pain on and off for two years and now it’s everyday 24/7.

  32. Anyone got experience of how long Tramadol ER actually lasts? I’m on Oxycontin and am finding it only lasts about 8 hours instead of 12.

  33. I’ve taken 400mg sr tramadol every day for 18 years for chronic pain. My question is, will it be doing anything to reduce my pain after all this time. I’ve always had residual pain anyway.

  34. I have been taken the regular tramadol but just a week ago went to extended release I have been tired and getting headaches if the extended release is doing this why what’s the difference from just regular

  35. What is the recommended time length of use for Apo-Tramadol/Acet 3.75/325 mg ?
    I have only used 1 prescription of this.
    I have chronic severe hip pain and it works for me, in combination with Gabapentin 600 mg daily.

  36. I have been taking 50mg every 8 hours as my dr says but i actually take 1 than 5 hours later 1more than at 7pm my pain and having neuropathy and bone pain and stiff ness What does should i be taking.

  37. I’m taking 10 mg oxycontin 2xd for pain relief and RLS control. I’m finding that it doesn’t last the full 12 hours and I’m experiencing problems in the early mornings. Does Tramadol ER really last the 24 hrs and could I change from one to the other without too much difficulty? Thank you.

  38. I am going on holiday and I have got tramodal for my hips so if I took just one in the morning would I then be able to drink later that evening as that would be 8 hours later

  39. Hello, My brother is 26 age and he take tramadol , I do everything but no response He is very thin please help me get me advice how I release his tramadol’s a request

    1. Hi Aradhana. I suggest that you call the number you see on the website to get in touch with a trusted treatment consultant.

    1. Hi Ray. After only a week on tramadol, symptoms should not take too long to subside. The nausea usually goes by within a few days.

  40. My mom is take tarmadol since two month and ever since her Blood pressure is high today we realize that its increasing due to tramadol please let us ml know how to flush through her system and she was taking 50 mg entire day please help

    1. Hi Afshankhan. I suggest that you call her doctor to prescribe water pills for high blood pressure.

  41. If someone is addicted to tramadol.. How can he be free from tramadol.. Whats are medicine or other way to get out of addiction??

  42. If you experience nausea on and off taking slow release Tramadol 100 ..does that decrease as you continue to take a daily tablet or does it always remain the same?

  43. So i was just perscibed tramadol for severe back pain. I had TLIF surgery on September 23,2016 to replace L2-L3-L4-L5. I had only Been taking 1000mg off ibuprofen daily before that. How often should i take. Says every 4-6 hours but should i only take when needed? Also found some old pills from whenI had my accident. How long is the shelf life?

    1. Hi Ron. Please use Tramadol as prescribed by a doctor. If your doctor has said to use them when needed, then do as he says. Moreover, each medication box has expiration date. Use the medication until that date.

  44. How long before nausea and stomach pain will not be strong just started medication a week ago yesterday need for bad back pain tramadol 200

  45. Hey! I took 400mg of tramadol at midnight today. Is it safe to eat oxycontin later today? Like at 05:00pm. I know all about the risks about respiratory depression etc.. Just thinking if the two drugs dont interact so well together, and may cause something unpleasant.

  46. My boyfriend drank a oitcher of beer n two more beers came home n took two of those pills not sure if they are extended release..he felt real dizzy anx slept most of the day anx feels nausaited…. Is this what happends wjen u nix with alcohol and ots been 24 hours when will he feel better

  47. How long after 50mg tramadol can I take Endone 5mg?
    My back is in agony and the tramadol did nothing, it’s been nearly 5hrs

    1. Hi Heather. I suggest that you speak with your doctor before taking any medication. Or you may consult with a pharmacist.

  48. Thank you for this info. When I take the med I am full of energy and very calm. I am concerned about because of the pain that comes to my neck and head. I am unsure tramodol is the villain.

  49. I was one suboxone for a few months… 2 or 3 mil daily… last Sunday I did my last bit and decided to go cold turkey… for 31/2 days I was sick as a dog… problem was Wednesday night I felt like I couldn’t breath so I got to the hospital to find out I needed a blood trasfusion… he gave me a script of tramadol 50s…. my last tramadol (which I only took for 4 days)was almost 2 days ago…i feel okay but my question is this…..will I got back into withdrawal from suboxone? If I had known it would set me back I never would have had them give it to me…pls answer asap and thanks! Ann

  50. I was prescribed 50 mg Tramadol with a surgery 3 weeks ago…1 50mg tablet every 6 hours…I want to stop taking them…can I reduce taking them by going to 1 every 8 hours for 2 days…..then 1 every 12 hours…for 2 days…then just 1 tablet per day for 2 to 3 days?

    1. Hi Taeun. I’d suggest that you speak with your doctor to help you create an individualized tapering schedule.

  51. Does tramadol really work, I torn my supraspinatus, and the last time I torn my shoulder muscle I had to take 3 pills of hydrocondone, just to feel better, I took that med 4 3 yrs.

    1. Hi Amelia. Please use Tramadol only as prescribed by a doctor. And, do not use it after the expiration date, you put yourself at risk.

  52. I cracked my rib this morning and I was given a shot of tramadol in my backside (muscle). How long does this stay in your system as I’d really enjoy a glass of wine right about now. Thanks!

    1. Hi Carmel. Have you reported this symptom to your doctor? If not, I suggest you do. I am sure something can be done.

  53. Hi ive to take tramadol for lumbar spine. Should i still be sleepy after taking one at seven this mornin its now nearly nine

  54. I’m having the sysmptom of tramadol and it killing me.please what drugs can I take to ease the pains.I’m really having an uncomfortable feelings alover me.thank you if I get a reply quickly on that

  55. So a friend of mine snorted a third of 37.5&325mg pill and hasn’t done them before he had severe back pain from fracturing 2 vertebrae and is feeling loopy he wants to know how long these affects will be active.

  56. My husband is taking 50 mg of tramadol. I believe 1-2 pills every 4-6 hours. He has exhibited signs that resemble heroin use. He nods, he hallucinates, he has severe mobility problems. He keeps falling. He mumbles when he speaks and when I do understand him, his comments make zero sense. His ankles, feet, legs, hands and face have been swelling too. I have to babysit him 24/7 because he is a danger. I can’t even leave to pick up some milk. I hid his remaining pills. He has five left and isn’t due to be refilled for 8 days. So, I am baffled as to why he is still “loaded” more than 24 hours since his last dose. I hid them about 32 or so hours ago. Can anyone explain how they continue to effect him like this?

    1. Hi Beverly. I suggest you speak with a doctor about your husband’s condition. Maybe, he’ll need to do a drug test or other medical examination.

  57. I take 1 50 mg tramadol in the morning. Ben taking them for 4 or 5 months.
    Am i ok to just stop taking them now i don’t need them anymore.

    1. Hi Jim. Experts claim that slowly reducing Tramadol dose is a safer way to quit the drug. So, I suggest you speak with your doctor to help you plan an individualized tapering schedule.

  58. I have been on 100mg tramadol for a few months after surgery, I have run out but have hydrocodone acetaminophen. Am I able to start on those and how long after tramadol may I take one of them. Please help me out and give me an answer please.

  59. I have been taking ink. Tramadol about 600 mgs/ day for last 10 years. I have stopped now but my seems so sensitive to even mild touch and I feel jitters and fearful all day. When I can feel normal?

  60. 76 yr old male with non- diagnosed chronic pain in hips, legs, knees. 1 week ago
    I was given a prescription for 50mg Tramadol every 6 hrs. I feel relief and am considering
    taking maybe 50 mg every 4 hrs for more pain relief–that would be 200-250 mg per day.
    Doc says ok however I am a recovering alcoholic (17 yrs dry) and have an addictive
    personality. Getting mixed answers from pharmacists regarding addiction possibility.
    P.S. only side effect for me is constipation.

  61. I have chronic back pain and was given a tramadol injection, not sure of the dose. Whilst I feel some effect, dopey, fuzzy, I have not had any pain relief at all. It’s been 2 1/2 hours, will I get pain relief and if not, why?

  62. Have stopped a ten week course of slow release 100mg every twelve hours for chronic knee and back pain. have been very sick stomach cramps, severe headaches and constant sweating an long before this stops.

  63. Hi! 2 yrs ago I was in a bad car accide after 1 month i hhad a bad fall at work because of the wet floor! I was on tramadol for almost 2 yrs! I don’t want to be on medication any more but I fill like i need to take the tramadol juat to fill beter! This is taking over my life! Please tell me what can i do!

  64. I was in a car accident and they gave me an injection in the ER on Thursday it’s Saturday today and I have a lot of pain in my arm in the area where the injection was and I was wondering how long with this last . I’m having a hard time raising my arm and moving it, I also feel pain in my stomache

  65. I took tramadol for a little over two months post total knee replacement surgery before I weened myself off, gradually tapering down from 8 a day to 1 to none. And, as soon as I stopped taking the drug all together, I was hit with a barrage of unusual symptoms, such as an intense sensation of burning skin on back, arms, hands and face; severe stomach cramping and bloating; severe headaches; fatigue, weakness and some dizziness. That was two weeks ago,. Now, I still am having moderate to severe stomach issues and fatigue with mild headaches and I have lost 10 pounds. But, most of the other symptoms have disappeared or diminished greatly. My question is: can the lingering stomach issues and fatigue still be attributed to 2 months+ tramadol use or should I start seeking other explanations?

  66. I took it last night around 10:30 and i woke up this morning around 8:30 still feeling drowsy is thos normal i was perscribed this for pain due to ectopic pregnancy

  67. Not an opioid. This is why it was prescribed for me in 1997. My then-doctor didn’t want me on anything addictive to cure my migraines. Tramadol did nothing for my migraines. (Imitrex, et al, were not yet on the market). Tram worked quite well as a mood stabilizer, though. I stayed on 400mg @day, but after a while that wasn’t enough. During a work day I would feel great in the mornings, then experience minor withdrawals by late afternoon. The doctor took the unusual step of sending a blood sample to a genetics lab, to see if I was a garden-variety drug seeker. We learned that my metabolism rate was twice that of the average person. Random tests with other medications yielded the same result. From medicines as useless as Tylenol, to allergy medications to heartburn medications, all the way up to OxyContin, my body metabolises drugs at double-time. The only solution subsequent doctors have offered is to lower my doses, allowing me to take several small doses (depending on the drug) rather than one large one. Of course, this renders the medications all but useless, but doctors will not chance increasing my daily pill count, for fear of turning me into an addict. So migraines, arthritis, torn tendons in arms, diseased lower-back discs, PTSD, severe anxiety, agoraphobia, clinical depression, and insomnia all are half-treated. Has anyone else been diagnosed with this genetic mutation?
    Last thought: withdrawals are horrific and do not end. I was taken off for 7 months at one point. Lost my job, increased my appetite (severe weight gain), plunged into severe depression, my husband left me…it’seems a lifetime commitment for some of us. Liver panels every six months show no damage whatsoever. I will continue to take them as mood stabilizers in order to get by with living. Otherwise, I beg anyone: if this drug works for you, think carefully about staying on it for chronic conditions. It may become a lifetime commitment.

  68. I have severe back pain and I used to take Tramadol milligram about three months ago,but I been on oxycodone 7.5 milligram and I ran out so I took one of my tramadol 50 mg how long do I have to wait until I can start back taking my oxycodone 7.5 mg.

  69. I went to the hospital for sever toothache. they gave me 2 50 mg pill. i felt dizzy and loopy . its been 7 hrs and i still feel super sick to mu stomache and throwing up, how long should this last!!! anything i can do to help feel better in the meantime?

  70. I am in extreme pain 24 hours a day and I take gabapentin 3 times a day, 6:00 am and 12:00 p.m. and 7:00 p.m. but my question is I also take tramadol 50 mg only 2 times daily 6:00 am and 12:pm and wait a full 18 hours before the next pill at again 6:00 am. My main question is I wait up in the morning exceptionally depressed, do you think 18 hours is to long between pills of tramadol .please help

  71. Hi,

    My father-in-law (a cancer patient, just off chemotherapy and blood transfusion) suffered from an allergic reaction to Ultracet which led to bad vomiting almost leading to dehydration. He had to be kept on IV for more than 24 hours and given injections to stop it. This was a week back, but he still feels like vomiting at odd times and has actually vomited 1-2 times in the last week.

    Could this be a continued reaction of Ultracet? Can it stay in human body for such long periods? Or we should start looking for other possible causes of this?

    Your answer will be very helpful

    Thanks & regards.

    1. Hi, Anu. I’m sorry for your father-in-law. I suggest you speak with a doctor about this matter, and run some extra medical examination.

  72. Hi I have been on tramadol 150mg sustained release for 6 months now I have run out of the sustain release and all I have is 50 mg immediate release left. I was just wandering if I come off the sustained release onto the immediate release will I suffer from withdrawals? Thanks

  73. I normally do not drink. I take 1-2 tramadol a day 50mg for arthritus I hv a special occasion coming up with friends I havent seen in 50+ years and will want to drink with them. If I do not take my tramsdol that day, will it be okay?

  74. Hello, I have been taking tramadol, which was told to me was not additive but habit forming, quit a difference, at the highest amount being 225mgs a day. I have tapered down to 125mgs a day to try to taper off of it completely. I have been taking it for approximately 8 years now due to a herniated disc. I see people on forums saying the last 50 to 25mgs are the hardest without serious side affects and the side affects are brutal and last a long time. Would you recommend an herbal opiod treatment of supplements to help the process?

  75. If i take tramadol before bed can i have side effects next day. Been nauseous and vomiting been 3 different times it has happen in past 3 weeks. Taking it for pain from car accident neck sternum injury.

  76. Hi doc,
    I’m 27 years old went to party for new years and had plenty of vodka then took a pill “”tarmadol ” which lead to vigor sex
    My friends thought it was a porn movie being played.

    Concern is, after that day I’ve been feeling wierd, feeling weird, sometimes I panic sometimes eyes feel dizzy sometimes I feel absolutely fine

    Mainly the eyes thing giving me a dizzy kind of feeling.

    I’m worried never had I encountered this oh yes and my penis tip is bruised (reddish purplish small kinda dots)

    Please help me understand this and advise on how to get rid of these symptoms please

  77. I have two different bottles of Tramadol. One is 50 mg taken twice daily. The other is 200 mg ER. Which one should I take for slight chronic back and knee pain, but more so the back. Also, I want to make sure that neither affects my sleep habits. I’m 69 years old and in good health. Just give me a plan A and plan B to run with with. Thank you much!

  78. i was having fever and pain in body so i have taken one tablet of trmatol paracitamol and thereafter i started my work but in evening my bp got up as 160/110 and on nxt two days it remains at 145/90 and thereafter now from a month i m suffring as heaviness in forehead or eyes and chilling sensation in head after 10-12 days also sometimes dizziness but with passage of time it i m improving What could be the reason .Now my bp is continuing as 130/80 And also my vit d level is coming 8 Please reply if u have any idea about my problem

  79. I have been taking Tramadol every day at a max of 300mgs a day but usually 200mg a day, not the time released just regular tablets , for 8 years, and cant find anyone who has been off of them for years. I would like to know if they cause any long term damage to the brain or nervous system etc.

  80. Was on tramadol ER 100 for a month, then was switched to the 200 for 29 days. Developed stomach and intestinal issues and had to stop taking this abruptly. How long will these symptoms last? Getting hard to bear!

    1. Hi, Lynn. Duration of tramadol symptoms varies from person to person. They can last anywhere from few days to several months after the last intake. Have you tried some over-the-counter medications and home remedies to ease withdrawal?

  81. I took tramadol yesterday at 3 pm, I was planning on drinking tonight but felt I should wait longer. If I wait another day will I be okay to drink? Thank you

  82. My husband is having a bad reaction to the tramadal/acetamenaphin combo pill dentist prescribed yesterday. He took 2 at lunch and 2 before bed. By 5am severely dizzy,vomiting,sweating,itching and restless. It is now noon and we have just gotten an anti nausea pill to stay down. When will this wear off?

  83. I want too try to withdraw off heroin using tramadol 50mg tabs. i do not get on with subutex wat so eva and dont want too go back on methadone. wat do you think.. Thanks.. Nick

  84. I also would like to know about the sex thing,every time i take tramadol i want sex but cant finish,how about if u drink a lot of water does that get rid of the effects faster?

  85. Hi,

    I suffer from Trochantric Bursitis, and I’ve had several steroid injections into both hips over the years to help with the pain.

    My ortho surgeon has given me anti inflammatories to help, but they’re no longer working. I’ve moved overseas for work and have started getting bad pain again. I’ve taken 400mg Tramadol tonight and that hasn’t taken my pain away. What would you suggest is a better option? I don’t want to take any more than 400mg in case I hurt myself.

  86. i took two 50mg late Tuesday night my anniversary was today couldn’t keep it up so went and bought a hard on pill from store it got up but couldn’t reach organism wife pissed how much longer before I can try to have sex without this problem

  87. I found 6 a day is just right when I wake up I find it difficult to function in only 47 but until I take my 6 pills within an hour I feel great.

  88. I have chronic back pain from Scheuermann’s Kyphosis. In 2005, at age 53, I tried a monster spinal fusion in an attempt to get my life back. We succeeded in altering the pain, but not reducing it. I live in Latin America now and self-medicate with 100mg tramadol long-acting in the morning along with 50 mg of the short acting. At night I take another 50 short-acting. This has been barely adequate for most of this time, Now I can’t stay asleep all night and I feel crummy and this has been true for several months now. I almost never can recoup with a nap. I plan to go to 200 mg of the tramadol long-acting, but wonder whether I should do 100 mg in the morning and another 100 mg at night (my instinctive choice) or 200 mg at one dose, while dropping the short-acting altogether. What do you think? And if one dose is better, when would be the best time to take it? I have no other medical issues. I don’t take any other meds except for a semi-random (and rare) calcium and iron. I drink _almost_ no alcohol. Addiction is not an issue and, if I am on the wrong site, please feel free to say so. I have an iron grip on what meds I take and what I eat. Thank you.

    1. Hi Mary. Always take your medication as prescribed, never less and never more. If the dosage you are currently on is not helping, contact your doctor and report this. You will either get switched to another medication or your dose will be adjusted to your needs.

  89. Hi, I had surgery a HYSTERECTOMY . Came home the next day it’s real painful but I’m hanging in there. I only take 2 – 50mg tablets wen I go to bed. So if only taken 6 pills in 4 days so I should be good. Right

    1. Hi Sylvia. Yes, you’ll be ok with the medication and after a short-term use you won’t have any problem quitting. I wish you a fast and successful recovery!

  90. How long should i wait to drink alcoholic beverages after taking 100mg of ultram? I had 10 teeth pulled on wed and i finished my hydrocodone 7.5mg this morning. In a painful and desperate moment this evening i took some left-over ultram and tonight I’m supposed to go see a friend and we are planning to drink alcohol. If its not safe, i wont drink. I cant find anything about how long you have to wait to safely drink. I dont know if anyone checks this still, but im hopeful i will get some advice. Thank you for your time 🙂

    1. Hi Kittie Kat. Tramadol effects kick in 2-3 after you take it. It is definitely not safe to drink alcohol within the same day of administering any amount of Tramadol. Medical scientists have concluded that it takes about 24 hrs and up to 5 days for Tramadol to completely exit your system.

  91. Hi I took a trumiadol tablet 50 mg for my back this morning will I be ok to drink later and will it be out my body by the time I go out ?

  92. Hello Kingsley. I cannot find any drug interactions listed. But you can double check with a pharmacist at the local pharmacy just to be extra sure.

  93. I did not get a euphoria, I felt anxiety, slowed breathing and very unsteady, yet still felt pain. Never again. I was hoping this was the answer to my pain. It was not. 🙁

  94. I am currently taking 2-800mg ibuprofen tablets 3 times a day for chronic back,pelvis,hip,and leg pain from a pedestrian vs car accident I was involved in on April 2nd 2010. I’m afraid all that ibuprofen is contributing to erosion of my stomach. Will tramadol be better to take and can you refer me to a doctor who will prescribe it? I currently have moved and I’m looking for a doctor in providence,R.I.

  95. Hello Amber. Are you prescribed Tramadol? How long have you been using it? Have you just started using it or just took it once? Is the dizziness a withdrawal effect since you quit Tramadol?

  96. if you take ten to fifteen tramadol you will be high all day, and when you wake up, you will still be high, it is a fact and one of the best absolutebest opiate buzzes

  97. Hi Marie. And congratulations, being pregnant is a wonderful thing. For yours and your babies safety, please consult your doctor or gynaecologist about this issue. It’s something that should be looked into with attention. Without knowing anything about your current health condition, it’s not wise for me to give you an advise.

  98. Hope you can help I’m taking prolonged release tramadol at a high dose, but I’m pregnant and I have severe morning sickness, I’ve been taking tramadol at high doses for 3 years an it wouldn’t usually make me throw up. I’m holding down 100mg prolonged release tablets for about an hour, whilst I haven’t seen them in my sick can you tell me if they would of absorbed in the hour cos a lot of posts say on instant ones absorb in an hour an I can’t find an answer anywhere, I’m not getting the full effects but if I repeat the dose which I know you shouldn’t if just throw it up in an hour anyway. Just want to know if one hour is long enough for them to be fully absorbed. Please help I’m struggling so bad

  99. Hi, yesterday i took 2 paracetamols a tramadol and also a cold and flu tablet to try and make myself feel better and not feel so sick. but i felt absolutely disgusting after taking them. 23 hours after and i still feel light headed and dizzy.

  100. Hi Mary. Fatigue is a common side effect from Tramadol. Fatigue has been mostly reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis. If you have any of these conditions, please call your doctor.

  101. I take 50g of slow release tramal 1 day a week to play a round of golf sometimes 2 games a week is this harmful. I will have maybe 2 glasses of wine when I have finished golf.

  102. I need help – my dad was on tramadol and is now lethargic and almost sedated like – he is in the hospital – can this med make you like that ? Even though he was not on it for a 24 he period? Thanks

  103. I can’t take many pain killers, Tramadol is one that I can, I took some last night for pain relief, usually I am ok, but this is the slow release, last 2 times.. I have gotten extemely high, not so much happy but dizzy, sick and almost an outer body experience, not pleasent for me. 24 hours later my head is over a bucket and i am struggling… I wouldn’t suggest them for people who don’t need them, I will be more careful now and especially as I know they are addictive!

  104. Hello Elise. The occurence and duration of of PAWS (protracted, or post-acute withdrawal symptoms) will depend on the level, frequency, and length of dosing on tramadol. Have you consulted with a psychiatrist yet? You may benefit from the short term prescription of anti-depressants as your body continues to adjust.

  105. Hi, Don’t know if anyone is checking this blog, but I’m going to give it a try.
    Back on 5-15-14 was my last dosage 50 mg of Tramadol. I worked with my Pain Management Doctor to ween down. I started 2-2-1 for 5 day, 1-2-1 for 5 days, 1-1-1 for 5days, 1-1-0 5 days, 1-0-0 for 5days. Along with the ween down schedule I was given a Clinodine patch 0.1 mg to year for 7 days x 4 wks. I did great through out the whole process other than the nausea I experienced when eating. I also incorporated the “Thomas Recipe”. I am curious to know how long before I am back to having a normal chemical level in the brain receptors? When will my brain produce its own natural dopamine in the brain?

    Any help

  106. We took my mom off tramadol because it was causing nightmares and hallucinations. How long will those side effects last? Its been 24 hours and she is still not back to normal

  107. Hello Nicola. This is a question for a pharmacist. Call or stop in at your local pharmacy for more qualified medical advice.

  108. Hi I have started to take slow release tramadol for severe pain could you please let me know over how many days should this start to work? I am taking 200mg morning and night? I was taking the ordinary one every 4-6 hours they actually seemed to have more effect. Can you explain?
    Thank You Nicky Crosier

  109. re my submissions on 7th and 8th april,
    i am now taking 400mg tramadol & 4 paracetamol per day and my back is now a lot better although I suspect that the warmer weather may have a bearing on this as well.


  110. I took an immediate release Tramadol last night at 10 p.m. (the whole pill). It’s now 1:30 p.m. the next day–over 15 hrs later and I still feel somewhat dizzy. How is that possible if the drug is only effective 4-6 hours? Wouldn’t the effects be out of my system by now?

  111. Hello Chris. If tramadol does not work and you’re experience break through pain, you might consult with your prescribing doctor and ask about the possibility of taking hydrocodone or oxycodone. These are stronger opioids with known risks of dependence and higher risk of addiction, but the stronger medications might help.

  112. i am supposed to take 300mg max per day.this does not seem to be enough as the pain is there all of the many paracetemols can i add to that dose (or should i ask for more tramadol or something stronger)

  113. Beth I have been taking tramadol and I know everyone reacts differently. I highly doubt that one 50mg pill is going to make you loopy. Constripated maybe but not loopy.

  114. Hi Beth. Check with your doctors or pharmacist first. Different types of drugs have coatings or release seals that break when you cut the drug. As long as it’s OK with the pharmacist, you may want to proceed.

  115. hi: I was prescribed tramadol today for back spasms and promised they wouldn’t make me loopy as other pain pills do. my question is; can I cut the 50mg pill in half to prevent this unwanted high? thanks for your time 🙂

  116. Hi Julia. Thanks for your question. An anethesiologist would best answer your particular question. My (unprofessional) hunch is that as long as tramadol is not in the system, and you have passed through the withdrawal stage, you should be OK for surgery and general anesthesia. But please seek medical advice first!

  117. Could you tell me if it is safe to have a general anaesthetic, involving intubation, two weeks after finishing a course of Tramadol? Many thanks, Julia Harvey.

  118. I took 400mg Tramadol last night to get high, its coming up to 24 hours now and I still feel off my face! I didnt sleep a wink last night even though I was drowsy as anything. I had no idea the high could last this long

  119. With sever back pain I know I’m being impatient! Took my first pill how long and how many to be effective! Thanks

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