Monday March 30th 2015

Can you get high on Zoloft?

Can you get high on Zoloft?


If you are one of many people getting on Zoloft and are worried about feeling high or euphoric on Zoloft, don’t. Getting high on Zoloft doesn’t happen very frequently.   And if you want to use Zoloft to get high, don’t bother. We review why here.

Zoloft chemistry and use

Zoloft is a type of medicine used to treat anxiety and depression. Zoloft is from a new class of antidepressants called selective serotonin reuptake inhibitors (SSRIs) and is thought to work by increasing the amount of serotonin in the brain, which changes the brain’s receptors to serotonin, making them more sensitive to this particular chemical. Similar and popular medications in this class of drugs includes Prozac and Trazodone.  The end result of using SSRIs is increased perceptions of happiness and fullness and decreased perception of pain. In other words, taking Zoloft can increase your quality of life.  But can it get you high?

Zoloft and euphoric effect

Antidepressants like Zoloft do not bring about happiness, they just relieve depression. The most common description of the effects of Zoloft is a gradual feeling that depression lifts.  Not of euphoria or feeling high. In fact, Zoloft starts working only after you take it regularly.  Most people start feeling normal after 3-6 weeks of taking Zoloft – the average time it takes for how long zoloft to work.  Again, people who respond to antidepressants are not euphoric but report feeling more balanced emotional states.

During clinical trials, for example, researchers found that Zoloft infrequently created feelings of euphoria associated with feeling high. These infrequent cases occurred in 1/100 to 1/1000 of people who took Zoloft, the same percentage of people who report prozac high.  By contrast and FYI, trazodone high is not even possible.  So although it is possible to get high on Zoloft, it is highly unlikely that euphoric effect will occur.

Can you get addicted to Zoloft?

Experts are still not sure if Zoloft is physically addictive, or not. Clinical trials did not reveal any tendency for withdrawal syndrome when you stop taking Zoloft or drug-seeking behavior that is typical of drug that produce a high. But Zoloft does affect the central nervous system and doctors need to be aware of past drug abuse because this can lead to misuse or abuse of Zoloft, characterized by tolerance to the drug, increasing doses, and drug-seeking behavior.

Questions about Zoloft

Please leave your questions or experiences below. We are here to help you and to help connect you with other people interested in Zoloft. We answer all questions personally and may even respond with a new article! Your feedback and comments are welcomed.

Reference sources: Daily Med drug info for Zoloft
MIT drug chart comparison
Stanford University Mood and Anxiety Disorders Laboratory info on antidepressants

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17 Responses to “Can you get high on Zoloft?
j j harper
8:52 pm December 26th, 2012

hi my names jj im23 year old male from detroit iI have never found zoloft to work for my panic attacts anixity or depression and it dose not get u high but may work for someone else xanax volumes and other benzos work for me though.

Jason Black
10:23 am March 18th, 2013


I have took 2 pills of Serlain (Zoloft) in february 2013.
The reason i took it was a few anxiety attacks.
It was 25mg to start up, but it didn’t feel good at all and i just stopped.

Is it safe to stop after just 2 pills of 25mg?
My dizziness and lightheadedness became 10 times worse after those 2 pills.

I am still verry dizzi after 40 days of stopping those 2 pills.
Is this something the Serlain did to me because stopping after 2 days and is this irreversible?


5:47 pm May 15th, 2013

My doctor prescribed Zoloft because I’ve been going through a lot. I didn’t want to take the medication but I thought it might help me with my over-thinking on everything. I took 50mg last night. When I woke up (which was at 4:30am) I felt very nauseous and shakey. I have a “high” feeling and don’t know if I want to sleep or I’m satisfied sitting and staring at the wall. I feel like a zombie however I feel like if I wasn’t in such a daze I could clean my whole house in a couple of minutes. Feeling like I have a lot of energy but too high to move to fast (I know that contradicts itself but hope someone can make sense of it). I’m wondering if should stop or lower my dose.

Janice Coleman
4:47 am August 10th, 2013

My doctor had me on 50mg and wanted to increase it to 100 so I decided it would be best if I did so gradually . I took 75mg today and what ever 1/100 to 1/1000 I guess I’m part of that rare percent because I’ve been feeling extremely euphoric all day , I didn’t sleep well at all last night and I don’t feel like I will be able to sleep tonight . My head hurts too .

7:19 am August 13th, 2013

Hello Janice. It does sound as if you’ve reacted to Zoloft unfavorably. I’d suggest an immediate phone call to your prescribing doctor to report the symptoms and to seek a suggestion for alternatives.

Pastor Chris Duffy
4:20 am November 18th, 2013

Thank-you for the pertinent information, I minister in recovery programs and found a loose bottle of Sertraline and wondering if it was something they were getting high on or to help out of depression. I will call them and let them know I have found their lost pills.
Chris Duffy

5:42 pm March 9th, 2014

I took my first Zoloft today, prescribed for mood disturbance, emotional reactivity, anxiety and depression. I’m high as a kite. This is seriously the best thing I’ve ever taken. What gives? I’m only 6 hours in!

2:01 am May 31st, 2014

Well, I do get high on Zoloft, and on lexapro. Zoloft is more of an amphetamine feeling.

1:57 am June 17th, 2014

Be careful taking this drug, I was addicted to MDMA for a very long time. I was prescribed Zoloft after a few Suicide attemts and after the loss of my girlfriend. (150mg tabs) I desided to end my life so I took somewhere around 16 pills. And yes, I did get high very high for days. I have been abusing them ever since. Zoloft taken in high doses will get you high. It is also very harmful to you. serotonin overdose is a real thing. Addiction to this drug is a real thing. Be careful. I am off to rehab tomorrow.

4:21 am July 30th, 2014

If i was pregnant is it possible that zoloft will kill my baby ? If so how much is too much ?

9:00 am July 30th, 2014

Hello Stacy. Some research associates use of Zoloft (sertraline) with a rare but serious newborn lung problem (persistent pulmonary hypertension of the newborn, or PPHN) when taken during the last half of pregnancy, as well as heart defects affecting the septum. The septum is the wall of tissue that separates the left side of the heart from the right side of the heart. Some other possible side effects include anencephaly, craniosynostosis and omphalocele, cleft lip and palate, respiratory distress syndrome (RDS), and autism.

Zoloft is assigned a “C” grade for safety during pregnancy by the U.S. Food and Drug Administration (FDA), but they also state that effects on unborn humans remain unproven, since researchers cannot ethically test any drug on a human baby.

3:03 pm October 29th, 2014

I found ONE ZOLOFT pill in my teenage daughters room. I found only one. If Zoloft does not get you high, then why would she have one? I am going to ask her about it but don’t expect a trustworthy answer. Please answer asap. Thank You.

3:20 pm October 29th, 2014

Hi Laura. You should definitely talk to your daughter. She’ll either tell the truth or you’ll know if she’s lying by the way she answers when you catch her off-guard. Most importantly, don’t have a judgemental approach because she’ll just shut you out. You can go further with an open conversation and motherly kindness.

12:18 am November 25th, 2014

Zoloft has saved my life, I have ptsd, depression and anxiety from finding my husband dead next to me in 2008, I started Zoloft 50mg 3 mths ago, i saw a change in my moods after a week all though they were not fully gone.. But it has helped me alot. the 1st week i was sleepy but my body had to get use to it. I went for a check up today and my raised me too 100mg and im sleepy again but im sure it will pass…

11:54 pm March 2nd, 2015

I started taking 25mg of generic zololt 20 years ago, I was 38. I increased the dose to 50mg about 15 years ago, I was 43. I have been taking the 50mg every morning for 15 years and my anxiety (GAD) along with mild depression have NOT returned in any way. I could be a poster child for Zoloft.
Until…. 4 months ago. I started experiencing ringing in my ears, dizziness and a one day episode of vertigo. I’m experiencing more stress than usual at this time in my life, caring for my 84 year old Mother in her home (I have a home of my own so I do not live with my parents). I managed to make it through the holidays with no anxiety/depression feelings and even into the new year. But In Feb I went to see my MD and ask if there was anything I could do to relieve the ringing in my ears. He prescribed a diuretic pill. That was Feb 2nd. I took 5 doses. No way, I stopped the dosage after 5 days. I lost 10 pounds, I was nauseated, my appetite was gone. Kind of sent me in a tail spin of anxiety/depression. A week later I found myself in the ER with overwhelming anxiety feelings. My MD of 34 years saw me on the 18th of Feb and suggested I raise my dosage of Zoloft to 100mg. Now I have always had a hard time with taking meds especially anxiety meds. That is why I started and stayed on 25mgs for 5 years. It worked very good for me then and I was happy I got my life back and went on with life. When I started taking 50mg the same was true. I was in control within 4 weeks and back in balance by 8 weeks. So now, Mar 2, I have been taking 75mg of generic Zoloft for 13 days. I’m still so nauseated, appetite is returning very slowly, I’m having trouble working, and I’m so worried that the 75, 100, or any dose will not help now since my body may be immune it . Anxiety is still incredible!!! Why did my 50mgs “poop out” on me?? And has this happened to others? I need some encouraging words. I don’t want to change to some other anti-depressant EVER!!! Im now 58 and I am more than willing to take Zoloft for the rest of my life.

6:27 am March 16th, 2015

So the first couple days I took Zoloft I got this really high feeling and I wasn’t sure if I was in reality or a dream and once I thought my heads and feet where missing. Is this normal or no? I’m kind of worried if that made my schizophrenia worse or not…

12:00 pm March 16th, 2015

Hi Sophia. It’s a usual thing to experience when starting a new medication…until your organism adapts to the presence of the substance. But it will be normalized soon. It’s good to report these effects to your prescribing doctor. You may need to be started at a lower dose, which will be gradually increased over time.

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