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Can you get high on promethazine?

Can you get high on promethazine?

Yes, promethazine can get you high.

So, if you take promethazine to get high, will you get addicted? We review the use of promethazine hydrochloride, euphoria and the risk of promethazine addiction below. As always, your questions and comments are welcomed in the comments section below.

Promethazine chemistry and use

Promethazine is an antihistamine which is used clinically for the temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold. Further, prescription-strength promethazine combined with codeine cough syrup is legitimately used to treat allergies, bronchitis, the common cold, influenza, and sinusitis. The three main characteristics of promethazine include:

1. sedative effects
2. the ability to treat allergies
3. prevention or alleviation of nausea and vomiting (antiemetic)

Promethazine is an H1 receptor blocking agent which affects the central nervous system. In fact, drowsiness is the most prominent effect of this drug. However, most people take promethazine in combination with codeine (a prescription opioid) as a prescription strength cough syrup. And it is the combination of codeine and promethazine which most likely leads to euphoric effect.

Promethazine and euphoria

Cough syrup that combines promethazine and codeine is the main ingredient in a drink called Purple Drank. Drinking Purple Drank results in a sedative and woozy or swooning euphoria. But when you drink a combination of promethazine and codeine for effects of mild stimulation and intoxication to dissociation…the risk for developing dependence on the drug increases. Even more, Purple Drank has contributed to overdose deaths.

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And although it’s rather unlikely that you can become addicted to promethazine on its own, you can get addicted to codeine. If you are taking a promethazine and codeine combination you MUST KNOW that psychological dependence, physical dependence, and tolerance are known to occur with codeine.

When do people get addicted to promethazine?

Promethazine is readily available and pretty easy to get. But promethazine hydrochloride and codeine phosphate syrup is a Schedule V Controlled Substance. This is because although it has a medical use, it can be abused. And abuse of cough syrups containing promethazine may lead to limited physical dependence or psychological dependence. So how do you know if you are addicted to cough syrups containing promethazine, or not?

First, you have to separate the promethazine from codeine. Although promethazine is known to cause euphoria, codeine is more likely to cause it. So if you are drinking Purple Drank, know that your body and mind can start to NEED the drink instead of WANT it.

Second, there is a distinction between addiction and dependency. You can be dependent on cough syrups with codeine without being addicted to them. Addiction is generally characterized by psychological needs such as lack of control of drug use, compulsive use, continued use despite harm, and craving. But people who are physically dependent on codeine can withdraw from it and not take it again.

And finally, if you are taking promethazine with codeine to get high, you are at risk of becoming addicted to it. Why people get addicted to drugs is different for every person. No single factor can predict whether a person will you become addicted to promethazine and codeine, or not. In fact, risk for addiction is influenced by individual biology, social environment, and age or stage of development. But in general, if you are taking something to get high, and continue to do so over time, your body and mind will start to change chemistry and make durg use the most important part of your life.

Questions about promethazine

Do you have more questions about the use or abuse of promethazine? Maybe something to share with us. We publish all relevant comments here, and answer all your questions personally. Sometimes, we’ll even write a new article just for you. Please leave your ideas below. We look forward to hearing from you.

Reference sources: Resurgence in Abuse of ‘Purple Drank’ from the U.S. Department of Justice
FDA drug information on promethazine hydrochloride and codeine phosphate solution
National Highway Traffic Safety Administration Drugs and Human Performance Fact Sheets

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9 Responses to “Can you get high on promethazine?
5:16 am November 27th, 2011

can you get high from promethazine if it does not have codeine in it?

5:44 am November 28th, 2011

Hi Dre. From our research, it looks like most people get high from the combined effect of promethazine and codeine, not from premethazine alone. Does this help?

10:50 pm March 31st, 2014

I take 25mg tablet of promethazine for nausea and I was wondering if it is addictive?? Or can it cause stomach problems with continued use??

6:50 pm May 1st, 2014

1.Promethazine will NOT get you high. Ever. It will cause mild sedation, but will not cause euphoria. It is only codeine that will cause euphoria. This article is very misleading. False information is what contributes to the dangers of drug use.
2.Promethazine+Codeine does not cause stimulation or dissasociation. It is a depressant, not a stimulant. It is not a dissasociative and has no qualities of a dissasociative.
3. The section on addiction is misleading as well.
You were comparing what is called psychological addiction(and you called it dependency) to physical addiction(which you simply called addiction).
They are both addictions, they are both dependencies. You can be dependent without being addicted, but if you are addicted, you are dependent.
4. And no, government sites are not a good source. They are often very biased. Instead, your sources should be from medical and scientific journals, where you get 100% unbiased facts.

1:39 pm May 29th, 2014

Will Promethazine by itself, without codine get you high? Like if you were to just eat as few, or snort some? What would be the side affects?

7:49 pm October 17th, 2014

If you take methadone and take the promethazine it will get you high.the promethazine intensifies the methadone wich is an opiate.add a benzo like xanax or klonopin and its a party:-)

1:55 am October 23rd, 2014

Yeah, great idea to suggest mixing promethazine with methadone and benzos. Lets potentiate two respiratory depressors together. Hopefully someone with an undiagnosed respiratory disorder doesn’t try that and die because of you.
Just cause you haven’t had problems doesn’t mean you should recommend doing stupid.things to people.

3:34 pm April 10th, 2015

I am prescribed promethaxine for nausea and I’m on 39 milligrams of methadone maintenance, which means I have to take methadone daily, from being addicted to opiates. The methadone does not get me high. Idk if anyone out there knows about methadone maintenance. I’ve been taking methadone daily for 5 years and I’m coming off of it, tapering, and the promethazine does not get me high, and I’m also on valium 5mg twice daily. My point is that everyone’s chemical make up is different. Everyday your body changes so maybe one day the promethazine will get me high. I know if you take a couple more promethazine at once it gets you a buzz. When I did that, I took 3 25mg, I was in a trance and everything was in slow motion and I would tell somebody something and totally would not remember!! I was scared to death!! I thought I was gonna drop dead!!! I will NEVER do that again. But taking one pill three times a day if needed just gets rid of nausea. I know this post is long, and I hope maybe the info will help someone.

11:39 pm June 4th, 2015

Is yellow promethdazine with codeine stronger than the purple one? If not, why they have different colors?

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