Wednesday April 1st 2015

Can you overdose (OD) on Wellbutrin?

Can you overdose (OD) on Wellbutrin?

Yes, you can OD on Wellbutrin.

What can you do to protect yourself from an accidental Wellbutrin overdose? In this article, we’ll explore that question in more depth, along with the risk factors for Wellbutrin overdose. At the end, we invite your questions about Wellbutrin and overdose.

Can you overdose on Wellbutrin?

Yes, you can overdose on Wellbutrin. Because this antidepressant is usually indicated for long-term use, you will develop a tolerance to Wellbutrin over time. Therefore, increasing the frequency or amount of Wellbutrin you take in order to achieve the same effects as before is an easy way to unintentionally overdose on Wellbutrin. This is why Wellbutrin should only be taken in the doses recommended by your doctor.

Taking Wellbutrin in an attempt to “get high” – which is not a typical side effect of the medication – can also result in an overdose. In fact, Wellbutrin abuse can always pose the risk of adverse side effects. For example, mixing alcohol and Wellbutrin increases your chances of having a seizure.  And keep in mind that if you’re looking to snorting Wellbutrin good high, snorting Wellbutrin probably doesn’t get you high.

What happens when you overdose on Wellbutrin?

The most common complication of Wellbutrin overdose is seizure. Wellbutrin can also affect the liver when taken in high doses, and causes dangerously high blood pressure. Wellbutrin abuse can also contribute to mental disturbances and psychotic behavior.

How many Wellbutrin is too much?

No more than 100 mg of Wellbutrin should be taken at a time. Although it’s possible to overdose on Wellbutrin, the safe dosage is much lower than what would be toxic. At doses higher than 450 mg per day, Wellbutrin can cause seizures and other serious side effects. The fatal dose of Wellbutrin is fairly high - between 5.4 and 9 grams. But even though Wellbutrin stay in your system for weeks after use, duration of action is around 6-8 hours, which requires normal dosing of 3-4 times a day.

Wellbutrin overdose help

A Wellbutrin overdose prognosis will depend on a number of different factors, including your own size and body chemistry. Because the results of Wellbutrin overdose can be so unpredictable, it’s best to see a doctor as soon as possible after you think you’ve taken too much Wellbutrin. If you experience any symptoms of seizure while taking Wellbutrin, even if you haven’t overdoses, you should seek medical attention immediately and discontinue the medication.

Overdose on Wellbutrin questions

If you have any questions about safe amounts of Wellbutrin in your system, please leave them here. We are happy to try to help answer your questions about Wellbutrin, and will try to respond with a personal and prompt reply for all legitimate queries.

Reference Sources: DailyMed Drug Label: Wellbutrin
PubMed Health: Bupropion
Hazardous Substances Data Bank: Bupropion Hydrochloride

Photo credit: VinothChandar

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37 Responses to “Can you overdose (OD) on Wellbutrin?
kathy reed
2:56 am February 16th, 2013

I was told that 450 mgs of wellbutrin which is what I take daily will cause high anxiety. Is this true

1:50 pm February 18th, 2013

Hi Kathy. This is a question for a pharmacist. I’d suggest you call or walk in for a consult with your local pharmacy to evaluate your personal risk of increased anxiety.

6:12 am June 25th, 2013

Pharmacy gave me the wrong dose wellibutrin xl instead of wellibutrin sr which I take 2 times a day. for 5 days I have not slept. I feel very nervous and sick is this common

6:52 pm July 1st, 2013

Hello Pam. I’d suggest that you speak with your pharmacist as soon as possible to report the symptoms and seek possible answers. Yours is a question for a medical professional.

2:16 am January 18th, 2014

I overdosed a lot on welbutrin, Benadryl, Advil, Tylenol, and other medications for a year. I stopped overdosing but ever since my welbutrin overdose my legs always been restless, my heart rates not been normal and Ive never felt “ok” what should I do? What could happen?

9:38 pm January 18th, 2014

Hello Sara. I’d suggest that you consult with a medical doctor or seek a referral to a neurologist. Best of luck to you.

10:59 pm April 17th, 2014

ive been snorting wellbutrin and getting high on
this drug for about 1year how baddly well I
withdrawl if i stop taking this it safe to
stop. &how long will the withdrawls last..I’m
thinking about quitting.

8:37 pm April 20th, 2014

I overdosed a week ago with Wellbutrin 100mg, I took 30 pills and with it I took Lamictin 50mg 60 pills. All I’m left with is a few flashes from hospital and other than that I can’t remember things since the OD, is that normal?

10:53 am May 28th, 2014

My wife took 60 300mg bupropion she’s in hospital now will she be ok

1:46 pm May 28th, 2014

Dominic if I have at look at my experience then she should be ok as long as you responded in time and the doctors treated her right, she will however be very irritated and moody when she wakes up and whatever you do, don’t let them put restraints on her. it will make her more angry. just support her and show her a lot of love, but don’t treat her like she is damaged. My heart stopped while I was in hospital and they gave me adrenalin and CPR and electroshock. but I eventually came back by myself. so don’t give up on your wife.

9:08 pm June 20th, 2014

I’m on 200mg a day and today I passed out for a second, then I thought I was going crazy, couldn’t control my facial expressions and couldn’t stop my stomach from contracting and tensing up now my body is all achy …it’s Friday I will call my Doctor on Monday. Do you think this could be from the Wellbutrin?

2:31 pm June 24th, 2014

Hi, Nicolette. It’s probably a good idea to consult your doctor. Actually stomach cramps, feeling restless, and being unable to focus thoughts are some of the many possible side effects from Wellbutrin. What did your doctor say?

4:16 am July 6th, 2014

I accidentally took 400mg of the generic Wellbutrin (Bupropion), which is twice the dosage I’m supposed to take daily. I now have a horrible headache and loss of appetite. Will I be okay?

9:25 am July 7th, 2014

Hi Rachel. You can call the Poison Control Center at 1-800-222-1222 for a free, over the phone assessment of your risk of overdose or for further help and instructions.

Irma Jiminez
3:54 am July 17th, 2014

My daughter (34) has been taking welbuterol 150mg bid for 10 yrs. tonight she accidently took 2doses. I hr apart. Forgetting that she had. Already taken one.

11:45 am August 4th, 2014

my family member tried to commit suicide by taking her whole bottle of wellbutrin, . The effects are awful. While she isnt dead, she is left with non stop terrible tremors almost like a non stop seizure. She is hallucinating alot and non making any sense verbally. The hospital is not sure how much of this is going to be permanent. Please dont ever take more of this than you should, because this is worse than being in a vegetative state.

8:14 am August 7th, 2014

I should stop this but if I get a chest pain like almost some punches you in chest during high is that normal? I did do this many time the most I ever took was 23-25 it was scary to see what I saw. Don’t OD on this drug guys you will see stuff that’s moving trust me I seen it but it’s not there for example. I woke up because I saw I herd stuff on my ceiling. water drops falling onto my bed and I saw hermit crabs and a lobster and months spiders voices every wear I even. I feel death guys… Don’t OD……… Also guys it’s a type of high that makes you want to go away… I need talk to my med doc soon about it I’d want to od anymore but don’t want parents to find out.. DON’T OD ! The sh*t I saw is all real scary sh*t…..

7:45 pm September 5th, 2014

Dominic, can you update us how your wife is and what symptoms she had experienced. I found my brother deceased 4 days later after a large ingestion of 300mg bupropion tablets. My family and i want to know what he went through before his death. maybe you can give us some closure if your details matched what we know. thanks. Heidi

11:11 pm September 6th, 2014

Can I drink couple glasses of Vine after 12 hours taken Wellbutrin.
Thanks ins advance.

9:04 pm October 8th, 2014

I’ve been taking 600 to 800mg of willbutrin every day for about 2 weeks.I haven’t had a seizure or any signs of overdosing.just some paranoia..I’ve been told I’m a seizure waiting to this I have psy hological withdrawal when they take me.

3:34 am October 11th, 2014

I donated blood shortly after starting welbutrin, and I ended up passing out. (Very public place, pretty embarrassing.) Also, sometimes I feel nauseous and I can feel my heart beating harder. I just want to know if these symptoms are normal, and if they’ll go away

12:30 pm October 13th, 2014

Hi Curt. You are putting yourself at a higher risk for seizures and developing severe depression. Larger doses of Wellburtin are also associated with siucudal thoughts and actions, so I’d say it’s best to see a doctor and get help for quitting the drug.

1:09 pm October 13th, 2014

Hi Alyssa. I’d suggest you make a doctor’s appointment and get some bloodwork done. Maybe you need a change in diet and a multivitamin. But, in order to be sure it’s not the Wellbutrin causing the nausea and fatigue, see a doctor.

1:57 am October 14th, 2014

I take the 150mg twice a day but it does not seem to help me. Can I take one extra dose to see if it will help me without a possible over dose?

7:26 am October 14th, 2014

Hello Curtis. It’s not recommended by medical professionals to increase doses on your own. So, please make an appointment with your prescribing doctor and explain what you feel. He may switch you to another medication or increase doses, but you shouldn’t do it yourself.

8:18 am November 20th, 2014

Is it bad to take 7 at a time?

1:36 pm November 20th, 2014

I’m prescribed to take 300 mg of Wellbutrin, but I lost track earlier (I’m a new mom so a bit frazzled lately) and accedenitally too another one not even an hour later, I feel fine but this is only my second day taking medicine again since July 2013. Is this considered an overdose?

3:59 pm November 20th, 2014

Hi Emily. Please call your doctor or talk to a pharmacist. Whether it is to much for you or not depends on so many factors, but generally, you should be fine.

4:11 am November 24th, 2014

I overdosed last night not sure how many as I threw up after but I thought u was going crazy seeing thing couldn’t sleep felt like I was in a dream state. Really learned my lesson I didn’t go into ER just rode it out. My question is im a nursing mom when can I nurse again? He has had bottles since

6:40 am December 2nd, 2014

I took 9 150 mg of wellbutrin last week and felt really irritable but nothing happened i just felt anxious and my ears were ringing like crazy do you think i did any permanent damage to any of my organs or am I ok since its been a week and I feel fine

5:18 am December 12th, 2014

My husband took 900mg wellbutrin xl thinking it was ibuprofen. And he is crying now I have dealt with different drugs with him should I take him to the hospital for this?

5:01 pm December 12th, 2014

Yes, Rayna. Get him to the ER or call 911, at a dose of 900mg of Wellbutrin he’s at a high risk of seizures and other serious side effects.

12:57 pm February 14th, 2015

I just brought my 18 year old son home from ICU after an overdose of Wellbutrin. He takes wellbutrin, prozac and abilify and for some reason has convinced himself that Wellbutrin is a recreational drug. I’ve had to hide all “possible recreational” meds in our home in a hole in my pillow and I sleep on them to keep them away. But he found them, while I slept…he took the Tylenol with codeine I had from a dental appointment last week and set it to the side. Went for his wellbutrin bottle and snorted what remained in the bottle. 17 150mg pills. This was the third time he had done this…first time was 2 months ago and he snorted 30 100mg pills over the course of 2 days. I found out after the fact so no ER but I can report that he didn’t sleep for 3 days. When I woke up at 3am this morning and discovered he had found the pills he admitted to having snorted them all over the course of the previous 4 hours. I called poison control 1-800-222-1222 and theyy insisted he go to the ER because seizures are a common side effect of high doses of this medication. I immediately called 911. My son remained coherent. He was given fluids immediately and then placed in ICU on 24 hour surveillance due to an elevated heart rate. Now he is home. He is doing fine but the doctor suggested a follow up with a cardiologist because he found a heart murmur…an odd find because I’ve had my son extensively tested in the past at Vanderbilt because I feared some issue with his heart and after days of a monitoring they determined his chest pain was due to anxiety. Not heart problems. Although every professional I have taken him to tells him he isn’t really “getting high” on wellbutrin he insists they just don’t know. He swears he does. I’ve had his psychiatrist cut them from his prescriptions at this point. Of course, I don’t blame Wellbutrin for any of this. I am prescribed wellbutrin as well, I take it appropriately and it was at my suggestion my son even be given this medication because of how well it worked for me. My son’s fixation on the drug is what makes it dangerous. To the question “can you OD on wellbutrin?” my answer would be “of course. a side effect to an aspirin overdose is death. You may be UNLIKELY to die on an OD of 30 150mg Wellbutrin but seizures are no joke and they are common with high doses of this med. I personally wish that for my son, I’d never heard of Wellbutrin. But then again for myself, it was a God send. Welcome to the life of raising an addict…a life of doubt and contradictions.

3:40 pm February 17th, 2015

Thank you, Amanda, for sharing this story with everyone. I’m sure it can help many who have someone dear abusing Wellbtrin to know they are not alone. I also hope that someone abusing this drug will read it, so they can realize what it does to parents and loved ones. How is your son doing now? Is he getting any professional help to manage his behavior?

2:44 am February 18th, 2015

You’re welcome, Ivana. My son is doing fairly well. He is in treatment almost to the extreme. He has a psychiatrist, a therapist and an in-home counselor. I called all of them the day he overdosed to seek guidance and set a plan of action. Unfortunately we live in the South where the winter storm has shut down everything so all of those appointments have had to be postponed but as soon as possible he must go. He was in alcohol and drug treatment very successfully for a few weeks until he stopped going in late November. He had been passing every drug screen for weeks…I do believe that he began abusing his prescription medication because they did not test for meds for which a person is prescribed (until I suggested they do). He struggles daily and I struggle to help him. He is an adult and reminds me daily of that lol so it does make the struggle more difficult.

To anyone who has a loved one who suffers from addiction to Wellbutrin, no, you are not alone. I understand what you are going through. I was prescribed Wellbutrin when my 20mg daily paxil prescription made me feel groggy…and in the first week of taking Wellbutrin I immediately noticed a difference. I was active again and felt more upbeat. I ask that you are careful not to blame the drug. I’ve seen blaming the drug as a common argument and I can tell you it focuses your attention on the wrong source. The problem lies within the addict. Maybe it’s a behavioral problem and an act of rebellion. Maybe it is a true drug addiction. Maybe the psychiatrist needs evaluate medications because their current meds are not helping and they feel they must self-medicate. Either way, the problem is almost always with the person abusing the medication. Get your resources together, call the doctors, the therapists, bring in family (interventions aren’t just for television) but do focus on helping the person…not blaming the drug or even the drug dealer. Keep the faith! If you are reading this I would say you can agree that you won’t give up on your loved one…I’ll do all I can to help my son…so long as it is in a way that is a POSITIVE in his life!

8:13 am February 20th, 2015

I have been taking wellbutrin xl for about 1.5 yrs, 300mg. Recently my doctor suggested a dose increase to 450 and when I was checking my pillbox for the week I saw that I have been taking 2 300mg. I must have gotten confused bc prior I was taking 2 150mg. So instead of getting 300mg/day I have been taking 600mg/day. I have no idea how long I have been screwing this up could be anywhere from 5 days to 2.5 wks. I haven’t had any highly distinguishable symptoms of this. I have however experienced a terrible mood drop into a depressive episode (which is why I was supposed to go to 450). If I haven’t experienced any adverse side effects such as seizures are they likely to happen after I go back to my normal dose? Also, could the increased amt of wellbutrin have the opposite effect and actually increase depression and depressive symptoms?
Obviously since noticing it I will stop taking a double dose and I am going to get in touch w my doc asap just wondering if anyone had any insight in the meantime. Thanks.

1:26 am March 7th, 2015

I have taken to 300mg wellibutrin xr crushed I’m afraid of taken another one

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