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How much Wellbutrin is too much?

Wellbutrin is an antidepressant medication used to treat depression, seasonal effective disorder (SAD) and to help people stop smoking. In this article, we’ll look at the safe amounts of Wellbutrin and how much Wellbutrin it takes to overdose.  Although using Wellbutrin to get high is unlikely, we also review some of the risks of taking high doses of Wellbutrin.  Your questions about too much Wellbutrin are welcomed at the end.

Wellbutrin strengths

Wellbutrin comes in a tablet, as well as a sustained release and extended release formula. Wellbutrin may be prescribed in strengths of 75mg or 100 mg. You can develop a tolerance to the medication and eventual dependence on Wellbutrin if you take it long term. If you become physically dependent on Wellbutrin, doctors will have you decrease your dose gradually rather than stopping all at once to avoid withdrawal symptoms.

How much Wellbutrin is safe?

While it is possible to overdose on Wellbutrin, it’s never safe to take more than the recommended amount on your prescription. However, even at normal therapeutic doses, there’s a slight risk of seizures (about 4 in every 1000 patients), and this becomes more pronounced at doses higher than 450 mg per day.

How much Wellbutrin can you take at once?

Up to 100 mg of Wellbutrin should be taken at one time. And there is no medical reason which justifies higher doses of Wellbutrin. Plus, taking Wellbutrin in large quantities to try to “get high” is unlikely to result in any kind of euphoria, and is very dangerous.

How much Wellbutrin to overdose?

Cases of Wellbutrin overdose have been reported where individuals survived taking 12 g of the antidepressant medication – that’s 26 times higher than the maximum recommended daily dose. However, for many people OD on Wellbutrin occurs in lower doses, between 5.4 and 9 grams. But even at thes lower doses of Wellbutrin, you’re still likely to suffer adverse side effects which could be dangerous.

Toxic levels of Wellbutrin in the system

You can overdose on Wellbutrin by taking it orally. But it’s easier to overdose on Wellbutrin by taking it in ways other than prescribed (more frequently, in higher amounts, or by trying to abuse Wellbutrin). In fact, crushing a Wellbutrin tablet and snorting Wellbutrin SR, or dissolving it in water and injecting it, increases your risk of overdose or severe side effects.

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Furthermore, how long Wellbutrin out of system can be long, because of Wellbutrin’s long half life and slow rate of absorption.  This is why traces of Wellbutrin can remain in your system for days to weeks after last dose.

How much Wellbutrin is fatal?

Any amount over 5.4 grams could be fatal. While some people can take much higher doses and survive, it’s not worth taking the risk. Individuals can react very differently to Wellbutrin, so it’s important to only take it as directed by a doctor.

How much Wellbutrin should I take?

You should take the amount of Wellbutrin prescribed to you by your doctor. Never take more than recommended by a medical professional, and only take this oral medication as directed.

How much Wellbutrin questions

If you still have questions about Wellbutrin and overdose, please leave them here.  We are happy to respond to your questions personally and promptly.

Reference Sources: DailyMed Drug Label: Wellbutrin
PubMed Health: Bupropion
Hazardous Substances Data Bank: Bupropion Hydrochloride

Photo credit: Erin DeMay

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50 Responses to “How much Wellbutrin is too much?
Melody
7:19 pm September 25th, 2012

Was originally prescribed 150mg for two weeks with an increase to 300mg the week prior and of my period. At one point, it was decided to change to 300mg everyday. I mistakenly continued to take 1 pill for two weeks and then two pills the next two weeks – meaning 300mg for two weeks and then 600mg for two weeks. I did this for about 9 months. Can you tell me the implications? What kind of effects and how long they may last? Thank you –

L
5:53 pm March 8th, 2013

I mistakenly took a 300 twice instead of a two 150m pill once.

6:08 am March 9th, 2013

Hello L and Melody. I’d suggest that you call a local pharmacist to talk about mistaken increased doses of Wellbutrin and the side effects. A medical professional is the best source of information on drug effects and can help you identify steps you need to take.

dan
3:26 pm April 19th, 2013

I personal snorted 6 300 mg pills, I was extremely high, hearing voices and halusinateing. sorry cant spell.

Donna Rockwell
1:57 pm April 25th, 2013

I will be having lap band surgery soon and I need to know if I can crush Wellbutrin 100 mg into a powered form or very small crushed pieces? Please contact Asap. Thank you.

Lila
8:18 pm January 10th, 2014

My dr prescribed 300mg XL of wellbutrin, is this an error?

Jessica
10:25 pm March 10th, 2014

Recently I started taking my boyfriends bupropion because his mom said it helped her lose weight. I started at a lower dose, but as my tolerance built I increased the dose, wanting to keep my appetite very low. Currently I am taking two 300mg pills every morning. Some days I experience a dizzy uneasy feeling, and I worry about other on and off symptoms. I am also taking suboxone, and baclofen. I would just like to know if I continue to do this staying at the same dose, if that isn’t high enough to be too dangerous. Been looking online and I cannot seem to find anything that will answer my question instead of scaring me with pages of symptoms. I would really appreciate a response, the answer that I get will help me to determine what course of action I should take, as I don’t want to put myself in too high of a risk. Thank you

12:39 pm March 11th, 2014

Hello Jessica. I’d suggest that you consult a pharmacist…by phone. I’d ask for an assessment of risk to your person, and a suggested tapering plan. Best of luck to you.

Julie
3:42 am May 22nd, 2014

I take 200mg extended release right now and my psycoligist wants me to stay at it but I have problems more with SAD but when I do have SAD then I seem more like Major Depression issues. I want to come dow to 100mg for the summer. Is this a good thing to do. I am also talking to my Counsler and my doctor about all this but hopeing for more info on if I should decrease it for the summer.

Wanda
4:42 am June 2nd, 2014

I take 300 mg xl daily, I forgot I took it and took it again…what’s gonna happen??

ttapp
6:03 pm July 14th, 2014

took am meds 300mg wellbutrin x,l synthrod125cg and adipex p 3.7 aprox 6.00
at 11.00 am took all again, forgot I took it earlier. nurse at drs no help please read and advise

8:47 am July 15th, 2014

Hi ttapp. Call Poison Control Center on 1-800-222-1222 for a free, over the phone assessment of the risk of overdose and with help on what to do next. If you start to feel some adverse symptoms and reactions to the pills, you should immediately Call 911.

Paula
1:14 pm September 4th, 2014

I was started out taking Wellbutrin 100 mg for one month (increases by Phycho MD) the following month to 200 mg followed by 300mg. My memory became horrible. Couldn’t remember things I did on a daily basis plus grew very impatient and mean. I didn’t want to take this medication anymore and didn’t want to get in touch with MD because She’ll just say give it a chance or we’ll try some other drug. I have ADD THAT’s why I wanted to try a med, but it only made my systems worse. I cut my 300mg pill in half and took it (150mg) for a week then cut that 1/2 into 1/2 (75 mg) for 1week. Now i just read you should never cut or crush them, so now I’m a little scared,cause that’s what 8
Cause that”s what I did. I feel better off the Med have been juicing,exercising,and trying to get more sleep . I’ve had trouble sleeping and nightmares,other than that , i don’t think I’ve had any other side effects besides headaches as we’ll. I have 3 days left (of my 300mg pill cut into 1/4 equaling four 75mg each) should I go cold turkey at this point or continue to take the last pill I cut into 1/4ths?? thank you.

Susan
4:52 pm October 27th, 2014

My daughter took approximately 15 of the longest release tablets of 300mg some time between 10:30 pm and 3:00 am last night, and had severe hallucinations and seizures, which the hospital has not yet been able to get the seizures under control. She lost the ability to speak coherently at about 3:20 a.m. and is currently under strong sedation since they had to put her on a ventilator in order to keep her airway clear. I thought this would equate to 3 grams, but it looks like it equates to more than that – what is the actual gram count in 15 300 mg XL or whatever the longest release tablets are?

9:41 pm November 1st, 2014

Hi Susan. If she took 15 Wellbutrin pills from 300mg, she basically took 4500mg. That equals 4.5 grams. It is close to the amount needed for an overdose, but since every organism is different, some people need less to overdose. I hope she gets better soon. How is she doing?

andi
4:51 am December 17th, 2014

I took 3 pills of 150mg what is going to happen

2:49 pm December 23rd, 2014

Hello Andi. You are at a high risk of having seizures. Do you have anyone to drive you to the doctors? If not, Call 911.

Jay
10:23 am December 30th, 2014

I have been on 150 mg of Wellbutrin for about 6 months. I am also in therapy.

I have just come back from a stressful holiday with family and cannot get a hold of Dr or therapist. Out of desperation I took 2 tablets 1 morning while away, and felt great, a bit euphoric actually in comparison. I am struggling to get my emotions under control, even now that we are back home. Can I just increase my dose to 300mg without consulting a Dr?

Thank you.

4:26 pm December 30th, 2014

Hello Jay. I cannot advise you that it’s ok to increase doses on your own. In fact, using your prescription medications in any way other than prescribed is considered drug abuse. You’ll get through the prescription faster and will be left without pills for a few days, and then withdrawal symptoms will step in. Or your doctor can drug test you and your levels will come up higher than they are supposed to be, so you’ll get discontinued. Worst case scenario, you can get highly dependent or addicted to it.

Ruth
9:34 pm March 27th, 2015

I have been on 3 wellbutrin 150 mg xl for quite some time, prescribed by a cnp who specializes in phsyciatry. I moved and am seeing a new cnp who is family medicine and she wants me to take wellburtin sr 3 times daily instead. She says that I am very near overdosing when I take 3 xl’s.

Aren’t they all the same doseage, just different in the time frame they enter your body? I was always told the xl lasts 24 hours where the sr is 12 hour. I just want to make sure that I have the correct information when talking with my provider.
Thanks!

Cindy
11:59 pm April 18th, 2015

My husband was prescribed 3 (150mg) Wellbutrin daily. The pharmacy changed the prescription when refilled to 3(300mg) Wellbutrin daily. We didn’t think to check the pharmacy because the pill bottle had a sticker that said pills may appear different due to generics. My husband too the prescription for two months and while we were out of town he start having stroke like symptoms and was rushed to the emergency room. After a few hours his speech came back and then so did his motor skills. The ER release him and said it was anxiety. Then he had several more events like the first so after we got home the next day and he was still having the symptoms, we took him to a different hospital which admitted him. After a couple days in the hospital and MRIs and Cat scans they started questioning the high dosage on the bottle. Has anything like this ever happened and Is this possible? He was prescribed 450 mg total and the pharmacy ups to 900 mg. he is still having dizziness, headache, blurred vision, can’t drive, gets the shakes, can’t remember things he did yesterday and is not able to go back to work. How long will this last and is there anything you can suggest for him to do.
Thanks for any advice you can provide.
Cindy

Hi,
10:54 pm June 26th, 2015

Hi, I was prescribed Wellbutrin to stop smoking pot, but last night after my first dose of 150 ml, I couldn’t sleep all night, I also have a very loud ac, and the whistling of the ac made me think some one was yelling, but when I shut of the ac it went away, can someone tell me if I take this for two weeks, will I be able to stop taking then?

David
6:51 pm August 4th, 2015

Your blog on Wellbutrin says you “take up to 100 mg per day”. Don’t you mean 1000 mg per day?

3:27 pm August 5th, 2015

Hi David. Actually it’s “up to 100 mg of Wellbutrin should be taken at one time” meaning that that is the maximum recommended amount of Wellbutrin that should be taken in one dose. Now, doctors may recommend you take 2 or 3 doses daily, but each taken dose should never exceed 100mg. And the subtitle where you read it says “How much Wellbutrin can you take at once”, which makes the paragraph a true answer.

reta
1:50 am September 19th, 2015

I took bupropion sr for 6 months .I had ear problems the whole time, not ringing but popping and cracking and was real sensitive to noise. went to two ear nose throat drs. they could not find any thing wrong with my middle or inner ear. I was not able to do daily dutys at times. are these normal side effects?

Sandra
7:35 am November 13th, 2015

I took three instead of two

1:12 pm November 13th, 2015

Hi Sandra. Depends on how long you’ve been taking the Wellbutrin. If it’s been a while, your body has grown tolerance to the medication and there shouldn’t be any serious or worrying effects. If you do, however, experience any side effects, don’t hesitate to Call Poison Control on 1-800-222-1222 and get your risk of overdose assessed.

Hiram
6:45 pm December 1st, 2015

should i take more to speed up the process

8:26 pm December 1st, 2015

Hello Hiram. No. You should only take the dosage prescribed by a doctor.

Virginia
11:45 am December 2nd, 2015

I’m 33 years old. I took Wellbutrin for 5 years at 300mg/day after my sister died. A year after stopping the medication I started having non epileptic seizures, weakness, and migraines. I had never had any of those problems before. The first month I had over 120 seizures. They have tapered down greatly over the past year and a half. Nothing seems to help but muscle relaxers, lamotragine, and Zoloft. Could the long use and then stopping have caused these?

Lydia @ Addiction Blog
1:01 pm December 11th, 2015

Hello, Virginia. You’re right! Epileptic seizures may be side effects of long use Wellbutrin.

Destructodeb
2:24 am January 12th, 2016

My Dr has me taking 300 mg ER Welbutrin and I take 2 every morning. She also said that we could go more if needed. I am reading all this about not taking over 100 mg each dose and I don’t know what I should do. Do I stop taking the meds?

11:11 am January 12th, 2016

Hi deb. You might want to check in with a pharmacist for a professional, second opinion on dosing levels. You’ll need to consult with a medically certified and trained practitioner for qualified, trustworthy information.

Sean
11:44 pm January 31st, 2016

I take one 300mg pill a day and I am on a host of other drugs is this dangerous? I am irritable and anxious all the time in fact I get very aggressive should I be taking something else instead of Wellbutrin? thank you.

Lydia @ Addiction Blog
1:47 am February 2nd, 2016

Hi, Sean. I suggest you consult with your doctor about your concern.

J
3:54 am May 3rd, 2016

I’ve been taking buproprion and Wellbutrin XL since 2007 – 8, approx. I began with bein rx 15mg. I now am supposed to take 450mg, the strongest dosage.

While I enjoy the fact that I have not gained any substantial weight over these past years, there have been times when I have gained Tenn Yuo fifteen pounds and then I’ll lose them again by not eating add much and watching my intake.

Drinking? I DO NOT abuse alcohol. Well, let’s back that up, I no longer drink spirits. Anything that comes in a bottle with an overage of 20% alcohol, I won’t drink it. Vodka, tequilia, rum, whiskey, liqueur, not inside of me, thank you, but red wine and beer, I do drink. I will drink about for to five glasses of red wine AT HOME and odd to bed, I go. Same with beer, I’ll drink three or four beers eerily watching tv and off to bed I go. I’ve experienced no side effects thus far but i WILL say that I could never ever drink that much before. I do not feel the effects at all, so, I quit while I’m ahead. I’m in my later years and I will be seeing a therapist in the next coming weeks because it’s my belief that number one, the dosage is too high, number two, I’m scatter brained instead of focused, number three, I’m shopping like a maniac. The very things I’m not supposed to be doing, I’m doing more of. I WILL say that it does help curb the lows. The depression times aren’t as horrible and they last only moments.

Simone
5:23 am May 22nd, 2016

Hello,

Thank you for all of this helpful information.

For 3 months I have been taking 150mg of Wellbutrin a day and noticed that my previously severe depression had subsided. I felt better and slightly more active, but still not quite like myself again. I mentioned this to my doctor and she recommended increasing the dose to 300mg a day and suggested that it would give me even more energy.. I have been taking 300mg a day for about a week and my mood, energy levels, and physical being have changed drastically.

I now feel more sleepy. I yawn and sigh a lot during the day. I have noticed that I don’t talk as much as I normally do and feel much more introverted. I feel complacent. I have noticed that my hair is falling out a bit more and I have to urinate more frequently and suddenly. Today these new symptoms have worsened. I experienced anxiety, a low mood, slight depression and self doubt, and am easily triggered to cry.

I was wondering if anyone else has experienced these side effects from increasing their dose. I am not worried about overdosing as mentioned in this article, but am wondering if this is a clear sign that this new dosage is too high for me.

I do have the intention of discussing this with my doctor after the weekend, but am looking for personal experiences that may be similar.

Any and all tips and expert advice would be appreciated.

Thank you

Lisa
11:28 pm July 31st, 2016

What is I am on 300 mg a day for about a year and because I couldn’t remember if I took one dose, I took another two 75’s when I’m supposed to take two 75mg IM three times a day?

Max
3:38 pm August 15th, 2016

My Dr. Prescribed 150 mg wellbutrin once a day since cymbalta had been making me sweat like crazy and personally I think the meds have stopped working. He didn’t tell much about this medication but all I see are bad comments and side effects. Has anyone experienced good things? I like to have a glass of wine once in a while but the website says you shouldn’t have alcohol while on wellbutrin. I’m at the point where maybe I need a second opinion about what medication to take.

Ada
6:04 pm August 30th, 2016

My doctor prescribed Wellbutron (Bupropion) 150 mg for a week. Then 300 mg after 1st week. I didn’t know it was being prescribed for depression. I thought it was for fibromyalgia. I can’t sleep regularly and I have a lot of various pains. Could this be true?

Dan
10:22 pm September 19th, 2016

Have you ever heard of a situation where a person doesn’t metabolize Wellbutrin correctly and must take 900 mg to 1200 mg a day to get the result that a “normal” metabolizer gets at 250 mg a day?

Jen
4:19 am September 22nd, 2016

I’ve been taking Wellbutrin @ 300 mg. daily for over a year, but just had it increased to 400 mg. The doctor said I was on the highest dose she could give me @ 300, then upped the mg. after all. So, I was wondering how safe it was to take that much. After reading these comments, looks like it’s not that bad comparatively. Anyway, the higher dosage has taken me from severe depression to mild depression. Just 100 mg. has made all the difference. I can’t tolerate those serotonin drugs like Zoloft, Paxil, Prozac, etc. because they make me really sick as well as suicidal. I’m glad that Wellbutrin is the one thing I can tolerate for treating depression.

Katherine
4:47 am September 23rd, 2016

Since a lot of people have worried about overdosing on bupropion on only 300 or so mg, for me it took 800 mg for me to experience adverse side effects. A few days ago I took 500 mg at night, then in the following morning I took 300 mg more, mixed with 175 mg of benadryl. I experienced black specks in my vision, absence seizures, and when I talked to someone I couldn’t tell if I had actually said something out loud or if I just thought it. Reality was incredibly distorted. I ended up sleeping it off and I’m perfectly fine now. I know doses will affect people differently based on body weight, height, etc. but it took 800 mg for me for side effects to kick in. Also, anyone thinking of taking an overdose of wellbutrin for whatever reason, don’t do it. It’s not fun, it’s utterly terrifying.

Elizabeth
8:17 pm September 26th, 2016

I have colitis and most mornings after taking the medication I see the whole pill in my stool. What do I do take another one bc it hasn’t disolved I’m on buproprion hcl XL 150 1 x per day.

Lowell
8:59 pm October 2nd, 2016

If I was given 600 mg of bupropion every day for 12 days what are my side affects going to be?

Lydia @ Addiction Blog
4:41 pm October 14th, 2016

Hi Elizabeth. I suggest that you speak with your doctor about this.

Ronald
9:30 pm October 21st, 2016

I got confused and took two doses in the same morning. My normal dose is 450 milligrams per day. That means I probably took 900 milligrams this morning. I’m feeling a little light-headed and my blood pressure is in the 150s/70s. In light of my elevated blood pressure and light headed feeling I think it might be a good idea to refrain from exercising today.
My body weight is 215 pounds. Would it be a good idea to increase my water consumption?
Do you have any other suggestions?

Agnes
11:53 pm November 4th, 2016

What is a higher dose-Wellbutrin SR 100mg twice a day or wellbutrinXL 150 once a day?
I am trying to find a way to reduce my dose because I am losing my hair and the medicine makes me anxious.

Nancy
1:38 am November 9th, 2016

I have been on 120 mg of cymbalta for over 2 years. My doctor had added 150 mg of Wellbutrin about 6 months ago because my depression was getting worse. That stopped working for me after about 5 months and he put me on lexapro with the cymbalta which did not work at all. Now he has prescribed 450 mg of wellbutrin along with my 120 mg of cymbalta all to be taken at the same time. Does that sound reasonable to you or should I check with my doctor again about the wellbutrin dosage. thank you.

Lydia @ Addiction Blog
12:33 pm November 15th, 2016

Hi Agnes. I suggest that you consult with your doctor to help you plan an individualized tapering schedule.

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