Thursday March 26th 2015

Can you get high on Prozac?

Can you get high on Prozac?

Yes. Euphoric effect has been reported by Prozac users.

But getting high on Prozac is fairly rare. In fact, only about .1 – 1% of users report feelings of extreme well-being while using Prozac. Instead, most Prozac users report stable mood improvements rather than feeling high. Can you benefit from the way that Prozac affects the central nervous system and increased availability of serotonin in the body? Learn more about Prozac mechanisms and how Prozac works here.

Prozac chemistry and use

Prozac is prescribed for mental health disorders such as depression, obsessive compulsive disorders, panic disorder and bulimia. Prozac is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs).  Other antidepressant SSRI drugs that you may have heard of include Trazodone and Zoloft.  Getting high on trazodone is not possible.  But getting high on Prozac and catching a Zoloft high are both possible.  Why?

Serotonin is a chemical naturally found in the body, which is responsible for mood, appetite and sleep. Increased or more readily available amounts of serotonin can help elevate mood, and contribute to feelings of well-being that are important when treating mental health disorders. So how do SSRIs like Prozac work?  You may be surprised to learn that scientists don’t really know HOW Prozac works yet. But they do have a theory. The active ingredient in Prozac, fluoxetine, blocks the uptake of serotonin in human platelets. So experts assume that Prozac inhibits neural uptake of serotonin in the central nervous system, making serotonin more available and elevating mood.

Prozac and central nervous system effects

Prozac may impair judgment, thinking, or motor skills. And you can experience nervous system effects such as changes in sleeping habits, tremors or shaking and even anxiety. But some nervous system effects are more serious and should be reported to your prescribing doctor. What are these symptoms and why do they occur?

Prozac, like other antidepressants, affects the central nervous system in ways that we cannot predict. And although Prozac can be very helpful for some people, Prozac has also been associated with an increased risk for suicidal thinking and behavior. It’s especially important that you monitor effects on the nervous system when you first start taking Prozac or during dosage changes. Symptoms of nervous system agitation should be reported immediately because they require close monitoring and possible change of medication. Report the following symptoms (especially if they are severe, abrupt in onset, or were not present during diagnosis) or any unusual behavior immediately to your doctor:

  • aggressiveness
  • agitation
  • anxiety
  • elation
  • hostility
  • hyperactivity
  • ideas of suicide
  • impulsivity
  • insomnia irritability
  • manic episodes
  • panic attacks
  • restlessness
  • worsening of depression

Mixing Prozac with other substances

Do not drink alcohol while taking Prozac, as the combined effect of the two drugs can impair decision making, clear thinking and reaction times. You should also tell your doctor about any other prescription medications, over-the-counter drugs, vitamins, or herbal supplements that you are taking. This is because some drugs interact very badly with Prozac. For example, you should not take any other medicines that contain fluoxetine hydrochloride while taking Prozac. Also, inform your doctor if you plan to discontinue any medications while taking Prozac.

Can you get addicted to Prozac?

We don’t know yet.

Prozac has been shown to be an effective medication for short term use (less than 13 weeks) but has not been clinically tested for long term prescription. Therefore, Prozac has not been studied enough to determine potential for drug abuse, tolerance, or physical dependence. However, only 1 in 100 to 1 in 1000 people on Prozac reported getting high on the antidepressant, indicating low risk for drug seeking behavior. But it’s still not possible to predict if Prozac will be misused, diverted, and/or abused in the future.

Questions about Prozac use or abuse

Do you have any other questions about taking Prozac? Or maybe you fear that you are abusing Prozac. Whatever your concern, please leave your questions below. We will be happy to answer them personally, or even write you a new article to address your Prozac question.

Reference sources: FDA approved Prozac drug label
Wikipedia topic on serotonin

Photo credit: brains the head

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15 Responses to “Can you get high on Prozac?
5:46 am April 15th, 2012

My husband started taking large amounts of prozac in january. There are no real prescription laws in this third world country we live it, so he freely buys it whenever he wants without a prescription. I’ve been noticing severe muscle twitching, light sleeping and severe sweating. Is he addicted? what should I do?

4:08 am April 17th, 2012

Hello amaryllis. Thanks for your question. The first thing that you can do is to address your concern directly with your husband. Get a feel for what he thinks, and why he is using Prozac, and if he wants to stop. Try to verify the amount of Prozac that your husband takes. Either ask your husband directly or find out on your own. Then, you can consult a family doctor where you live. Although many countries still do not have an understanding of addiction or addiction treatment, perhaps there is something that you can learn about local resources and get an opinion from your doctor.

But you need to know that you cannot change your husband or his behavior, whether he is addicted to Prozac, or not. He must want to stop himself. So, with this understanding you can seek help for yourself to learn more about what you CAN change (yourself) by seeing a psychotherapist, joining a 12 step group like Al-Anon, or reading self-help books on relationships or communication, or whatever it is that is going on with you. This may seem counter-intuitive, but if you decide to stay with your husband and he IS addicted to SSRIs, you need to be prepared for acceptance and tolerance.

How does this sit with you?

6:41 pm November 12th, 2012


I just started on a 10mg regimen today and, I guess my question would be… How long does this medicine take to really take affect?
Also does this medicine interact with the narcotics that I frequently take. The narcotics are not prescribed to me but I need them very badly at times- I have such a bad back and arthritis but I am scared to get them prescribed to me because I abuse the Narcs…I can’t go thru anymore withdrawals and if I take them for more than 4 days no matter if I only take like say, 2 percs a days, OMG… I get so ill and I don’t want to go on in life anymore…
So, when I take Narcs I get the feeling of being happy and peace, calmness, just overall a sense peace…. I am a very depressed person and have been since I was maybe 13… My mother just never got me help – I even told her on several occassions that I was in fact depressed…. I think that if I had gotten the help I need back then, my life would be much better… maybe I would NOT be a struggling single mother of one, can’t really keep a job…etc… and a narcotic junky (well used to be but not so much now)…
Anyway, I am really hoping that the prozac works, I can’t keep going on like this… I should have a least 5 happy days out of a month and be able to really interact with my daughter… I am so ashamed and I pray to God that this medicine works… I don’t wanna keep waking up feeling empty inside and wondering why God keeps waking me up to this horrible life everyday!

2:58 pm November 13th, 2012

Hi Da’Nyce. You are not alone! There may be some underlying emotional issues you can talk out with a counselor. I’d suggest that you call a pharmacy and talk with a pharmacist about possible interactions that Prozac has with pain medications. You NEED to know. Also, ask for more details about when Prozac starts working. And then, talk with you doctor about referrals for a psychologist. You can get help, and you can feel better!

3:35 pm November 15th, 2013

Have been on fluoxetine for approx ten yrs. I decided to come off it gradually over a period of three months & do not take it any longer but I now find I’m gettin horrible buzzing type feelings in my head & dizziness. It only lasts a few seconds but is quite unnerving. Shud I be concerned or is this a type of withdrawal ?

12:33 am December 19th, 2013

what happens if you are to overdose on prozac? Is it possible or can results be dangerous? what syptoms would occur if overdose were to happen?

11:08 pm May 18th, 2014

I am having nothing but trouble coming off Prozac, I hate it, and no longer want it in my system.
Please help me, is this something I can come off by myself or would I require medical confinement.
Please I am at the end of my rope here, and have too much to lose if I don’t get help.
Thanks for your time,

1:10 pm May 19th, 2014

Hello Clark. I’d suggest that you make a phone call to your prescribing doctor and request an individualized tapering calendar ASAP. Alternately, you can contact your local pharmacist and request standard tapering protocols. Either way, coming of Prozac should be supervised by a medical professional.

7:03 pm June 12th, 2014

The doctor has put my other half on fluoxetine 60mg a day but since she been on them she a different person ??? Gone of with our 9 month old baby and got a flat ??? It’s like talking to a stranger. She just doing rash things and just seems Hi. She also always yawning and I don’t know what to do because I think it just masking the problems she had in the first place as she always suffered with depression as she was on 20mg a day. Is this normal ???

3:39 pm June 20th, 2014

I’ve been taking Prozac 10mg for the past five days. So far, I am feeling more high and full of energy than I ever have been. I’m a little worried that I’m not having normal reactions to negative things in my life. For instance, I don’t feel angry or sad when I’m supposed to. Obviously, I don’t mind not feeling so bad but I worry that this isn’t normal. I don’t want to feel depressed but I don’t want to feel numb to real pain either. My husband thinks it’s because I’m drinking coffee too. But, I barely finish a cup in the morning. I don’t feel jittery. I just feel high. And, of course, I really like it at times. Is this a normal reaction? I will be seeing my doc soon to discuss these issues but thought I’d ask here to see if anyone else has felt the same.

4:16 am July 21st, 2014

John, could it be that your other half is just not happy with you? It looks like you’re looking to blame a drug for something that could be your fault. Most people on Prozac have moments of clarity, they sometimes lack basic emotion such as guilt. If she feels she had to stay with you just for the baby’s sake then there’s a chance to Prozac has made her unable to feel the guilt of staying with u and she’s decided the best thing to do is move on. Have u even asked her why she does what she does? If she’s in a bad way then u need to not make it all about u. You can never assume u know what she’s thinking

3:55 am August 21st, 2014

Dear John. it is normal for your SO to yawn. i take prozac and i find that it makes me yawn an insane amount. maybe you should talk to her doctor because by the way you are explaining her behavioral pattern it seems to me that Prozac is not helping her at all. This is crucial because you both have a young child and she is putting him or her in alot of danger so it seems. Maybe she needs another anti depressant to take also with prozac or just no prozac at all completely. i hope my reply was helpful to you.

1:47 am December 17th, 2014

could u get high off prozac or trileptal or cetirizine?

8:48 pm February 10th, 2015

Hi, I’m on 40mg Prozac daily. Since starting them I just seem to have a desire to get high, self medicate to get high. Is this a normal side effect? Will it go?
Thank you

12:36 pm February 11th, 2015

Hi Ellen. Do you feel a need to get high on any drug or medication or particularly Prozac? No, it’s not a common side-effect but it may be a sign of an addictive personality. Maybe you can ask your doctor or a counselor for advise.

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